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Analysis

1 / 1,153
1.WO/2026/013624DOUBLE STRANDED RNAI AGENTS, COMPOSITIONS AND METHODS OF USE
WO - 15.01.2026
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/IB2025/057021 Applicant NOVARTIS AG Inventor HUNZIKER, Juerg
Disclosed are, inter alia, double stranded RNAi (dsRNAi) agents inhibiting expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), for example, human HMGCR, compositions including the same, and methods of treatment using the same.
2.WO/2026/015829SMALL REVERSE TRANSCRIPTASES AND GENE EDITING SYSTEMS COMPRISING SUCH
WO - 15.01.2026
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/US2025/037333 Applicant ARBOR BIOTECHNOLOGIES, INC. Inventor LAPAN, André P.
Small-sized reverse transcriptase (RT) polypeptides derived from SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4 and fusion polypeptides comprising such an RT polypeptide and an RNA-guided nucleases. Also provided herein are gene editing systems comprising the RT polypeptide, the RNA-guided nucleases, a guide RNA, and an RT donor RNA for use in gene editing.
3.WO/2026/014855FUSION PROTEIN COMPRISING APOLIPOPROTEIN AND FC REGION-BINDING PEPTIDE AND USES THEREOF
WO - 15.01.2026
Int.Class C07K 14/775
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
775Apolipopeptides
 Appl.No PCT/KR2025/009774 Applicant RNAGENE INC. Inventor LEE, Woo Ghil
The present invention relates to a fusion protein and a use thereof, wherein the fusion protein comprises: an apolipoprotein or a fragment thereof; and an Fc-binding peptide (Fc BP) or a fragment thereof. According to one aspect, a lipid carrier comprising the fusion protein was found to exhibit remarkably improved targeting efficiency, and thus can be used to deliver an active substance to a desired target.
4.WO/2026/013176ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CARDIOVASCULAR DISEASE
WO - 15.01.2026
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/EP2025/069685 Applicant PROQR THERAPEUTICS II B.V. Inventor HOLKERS, Maarten
The disclosure relates to the field of diseases caused by high levels of LDL-C and/or fibrinogen, such as cardiovascular disease (CVD). The disclosure involves antisense oligonucleotides (AONs) for RNA editing technology in deaminating a specific adenosine in transcript molecules of the human Asparagine-Linked Glycosylation 12 homolog glycosyltransferase (ALG12) gene, thereby rendering a mutation from a serine residue at position 275 in the human ALG12 amino acid sequence to a glycine residue (S275G).
5.WO/2026/015832REVERSE TRANSCRIPTASES AND GENE EDITING SYSTEMS COMPRISING SUCH
WO - 15.01.2026
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No PCT/US2025/037337 Applicant ARBOR BIOTECHNOLOGIES, INC. Inventor LAPAN, André P.
Reverse transcriptase (RT) polypeptides derived from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, or SEQ ID NO: 5 and fusion polypeptides comprising such an RT polypeptide and an RNA-guided nuclease. Also provided herein are gene editing systems comprising the RT polypeptide, the RNA-guided nucleases, a guide RNA, and an RT donor RNA for use in gene editing.
6.WO/2026/013628DOUBLE STRANDED RNAI AGENTS, COMPOSITIONS AND METHODS OF USE
WO - 15.01.2026
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/IB2025/057025 Applicant NOVARTIS AG Inventor HUANG, Zhihong
Disclosed are, inter alia, therapeutic oligonucleotides for use in silencing a target gene in a cell or in a subject.
7.WO/2026/013643METHODS AND COMPOSITIONS FOR DESIGNING EPITOPE STRINGS WITH LINKERS
WO - 15.01.2026
Int.Class G16B 30/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
30ICT specially adapted for sequence analysis involving nucleotides or amino acids
10Sequence alignment; Homology search
 Appl.No PCT/IB2025/057068 Applicant BIONTECH SE Inventor ROONEY, Michael
The present disclosure provides computational methods for designing superior T cell epitopes followed by experimental verification, feedback and further improvement of cleavage linkers between certain epitopes.
8.WO/2026/015882HSV ANTIGEN FRAGMENTS AND RELATED METHODS
WO - 15.01.2026
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2025/037424 Applicant BIONTECH SE Inventor FURTADO, Raquel Mariska
The present disclosure provides compositions for delivery of HSV antigens and related technologies (e.g., components thereof and/or methods relating thereto).
9.WO/2026/015884COMPOSITIONS COMPRISING IRE-1 BINDING SEQUENCES AND USES THEREOF
WO - 15.01.2026
Int.Class C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
 Appl.No PCT/US2025/037428 Applicant HELIX NANOTECHNOLOGIES INC Inventor ROWE, Katherine
Disclosed herein are polynucleotides that can sustain payload expression and/or induce payload expression during cellular stress. Also provided herein are compositions comprising the disclosed polynucleotides, and methods of making and using the same.
10.WO/2026/015809COMPOSITIONS FOR REDUCING METHANE EMISSIONS IN RUMINANTS
WO - 15.01.2026
Int.Class C07K 14/195
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
 Appl.No PCT/US2025/037295 Applicant PASTURE BIOSCIENCES INC. Inventor ZEHNDER, Matthew
The disclosure provides vaccines, such as polynucleotide vaccines, against methanogens. The disclosure also provides methods of making the vaccines and or administering such vaccines to ruminants (e.g., cattle) to reduce methane emissions.
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