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1 / 7
1.WO/2022/162010SYSTEM AND METHOD FOR DOSE GUIDANCE AND REPEATED ESTIMATION OF FINAL DELIVERED RADIATION DOSE FOR A RADIOTHERAPY SYSTEM
WO - 04.08.2022
Int.Class A61N 5/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
 Appl.No PCT/EP2022/051766 Applicant ARDOS APS Inventor MUURHOLM, Casper Gammelmark
The present disclosure relates to a method for dose guidance for a radiotherapy system during a radiotherapy session, comprising the steps of: performing substantially real-time dose reconstruction to obtain a delivered radiation dose generated by a radiotherapy beam of the radiotherapy system in at least one volume; repeatedly estimating a remaining radiation dose based on an observed and/or simulated motion of the at least one volume; repeatedly estimating a final delivered radiation dose as a sum of the delivered radiation dose and the estimated remaining radiation dose; and providing dose guidance for a remaining part of the radiotherapy session based on the estimated final delivered radiation dose. The present disclosure further relates to a method of continuous estimation of final delivered radiation dose during a radiotherapy session and a decision support system for a radiotherapy system.
2.2022901230METHOD AND SYSTEM FOR IMAGE REGISTRATION AND VOLUMETRIC IMAGING
AU - 19.05.2022
Int.Class Appl.No 2022901230 Applicant Hindley, Nicholas Inventor Hindley, Nicholas
3.WO/2022/097013A KALMAN FILTER FRAMEWORK TO ESTIMATE 3D INTRAFRACTION MOTION FROM 2D PROJECTION
WO - 12.05.2022
Int.Class A61B 5/11
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
103Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
 Appl.No PCT/IB2021/060107 Applicant SEETREAT PTY LTD Inventor NGUYEN, Doan Trang
An iterative Kalman Filter method was developed to address the need for estimating randomly moving targets during cancer radiotherapy on a standard equipped linear accelerator. Extensive evaluation of this method using different treatment scenarios shows sub-mm accuracy and precision. In addition, the system and method allows the target (or surrogates of the target) to be monitored without the need of a learning arc, reducing additional imaging dose to the patient. In addition, the method and system performs robustly against imaging and segmentation noise.
4.WO/2022/006637DOSE-BASED OPTIMIZATION FOR MULTI-LEAF COLLIMATOR ("MLC") TRACKING DURING RADIATION THERAPY METHODS AND APPARATUS
WO - 13.01.2022
Int.Class A61N 5/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
 Appl.No PCT/AU2021/050735 Applicant UNIVERSITY OF SYDNEY Inventor MEJNERTSEN, Lars
Methods, apparatuses and systems are disclosed for dose-based optimization related to multi-leaf collimator ("MLC") tracking during radiation therapy. In an example, a method includes calculating a planned radiation dose using an MLC plan in an un-shifted dose volume, acquiring, using a radiation machine, a target position through motion tracking, and shifting the dose volume by the target position. The method also includes integrating a three-dimensional dose into a two-dimensional beam's eye view grid and fitting, using the radiation machine for each leaf track, an MLC aperture by minimizing a cost function. The method further includes calculating and accumulating a delivered dose based on the fitted leaf positions of the MLC and updating a gantry position and MLC leaves to update a next planned dose.
5.WO/2022/006633SYSTEM AND METHOD FOR CARDIAC STRUCTURE TRACKING
WO - 13.01.2022
Int.Class A61B 34/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
34Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
 Appl.No PCT/AU2021/050729 Applicant UNIVERSITY OF SYDNEY Inventor HINDLEY, Nicholas
Systems, methods, and apparatus are disclosed for cardiac structure tracking. An example method includes segmenting a diaphragm or respiratory surrogate, heart, and target. The method also includes performing a peak-exhale to peak-inhale registration and generating a respiratory motion model. The method further includes tracking the diaphragm using X-ray imaging and estimating a target position for an x-ray guided cardiac radioablation treatment. The example method provides directly, precisely controlled x-ray guided cardiac radioablation that accurately targets the substrates of cardiac ablation while minimizing doses to healthy tissue.
6.2021304685System and method for cardiac structure tracking
AU - 13.01.2022
Int.Class A61B 34/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
34Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
20Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
 Appl.No 2021304685 Applicant University of Sydney Inventor HINDLEY, Nicholas
Systems, methods, and apparatus are disclosed for cardiac structure tracking. An example method includes segmenting a diaphragm or respiratory surrogate, heart, and target. The method also includes performing a peak-exhale to peak-inhale registration and generating a respiratory motion model. The method further includes tracking the diaphragm using X-ray imaging and estimating a target position for an x-ray guided cardiac radioablation treatment. The example method provides directly, precisely controlled x-ray guided cardiac radioablation that accurately targets the substrates of cardiac ablation while minimizing doses to healthy tissue.
7.2846803Procedimiento para la selección de objetos in situ
ES - 29.07.2021
Int.Class A61B 6/03
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03Computerised tomographs
 Appl.No 16760919 Applicant Asto CT, Inc. Inventor FEAIN, Ilana
Un procedimiento de rastreo de la posición 3D de una diana in situ en movimiento (11), incluyendo el procedimiento las etapas de: (a) construir (91) un modelo computacional anterior de la diana in situ en movimiento y su entorno circundante; (b) dividir el modelo computacional anterior para proporcionar un modelo diana de la diana in situ en movimiento y un modelo exclusivamente anatómico de anatomías que rodean a la diana in situ en movimiento; (c) utilizar (92) una o más imágenes fluoroscópicas 2D en tiempo real distribuidas espacialmente de la diana in situ en movimiento para rastrear la diana in situ en movimiento; (d) comparar (93) el modelo exclusivamente anatómico con una o más imágenes fluoroscópicas 2D en tiempo real distribuidas espacialmente obtenidas en la etapa (c); y, (e) minimizar la diferencia entre el modelo exclusivamente anatómico y una o más imágenes fluoroscópicas 2D en tiempo real distribuidas espacialmente para proporcionar la posición 3D de la diana in situ en movimiento.
8.20210038921METHOD AND SYSTEM FOR GUIDED RADIATION THERAPY
US - 11.02.2021
Int.Class A61N 5/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
 Appl.No 16978847 Applicant Doan Trang NGUYEN Inventor Doan Trang NGUYEN

The present invention is concerned with a method and system for guiding a radiation therapy system. The method comprises: capturing an image of a target area to which radiation is to be delivered; analysing the image with a trained convolutional neural network to determine the position of one or more objects of interest present in the target area; and outputting the determined position/s to the radiation therapy system.

9.20210038916Radiation therapy systems and methods using an external signal
US - 11.02.2021
Int.Class A61B 6/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
6Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
 Appl.No 16978825 Applicant Doan Trang Nguyen Inventor Doan Trang Nguyen

There is disclosed a method for estimating the position of a target in a body of a subject. The method includes, receiving an external signal that is related with motion of the target; and using a model of a correlation between the external signal and the motion of the target to estimate the position of the target, wherein said position estimation includes an estimate of three dimensional location and orientation of the target. The method further includes periodically receiving a 2-dimensional projection of the target; and updating the model of correlation between the external signal and the motion of the target based on a comparison of the estimated position of the target and the 2-dimensional projection of the target. The method is used in guided radiation therapy.

10.2020902396DOSE-BASED OPTIMIZATION FOR MULTI-LEAF COLLIMATOR ("MLC") TRACKING DURING RADIATION THERAPY METHODS AND APPARATUS
AU - 30.07.2020
Int.Class Appl.No 2020902396 Applicant The University of Sydney Inventor KEALL, Paul
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