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IC_EX:A61K39/42 AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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Analysis

1.WO/2006/086561NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST SEVERE ACUTE RESPIRATORY SYNDROME-ASSOCIATED CORONAVIRUS
WO 17.08.2006
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Appl.No PCT/US2006/004599 Applicant NEW YORK BLOOD CENTER Inventor JIANG, Shibo
The present invention provides an isolated antibody capable of binding to the receptor- binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) so as to competitively inhibit the binding of the SARS-CoV to host cells. These mAbs or substances can be used: 1) as passive-immunizing agents for prevention of SARS-CoV infection; 2) as biological reagents for diagnosis of SARS-CoV infection; 3) as immunotherapeutics for early treatment of SARS-CoV infection; and 4) as probes for studying the immunogenicity, antigenicity, structure, and function of the SARS- CoV S protein.
2.WO/2007/084583SOLUBLE FRAGMENTS OF THE SARS-COV SPIKE GLYCOPROTEIN
WO 26.07.2007
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2007/001270 Applicant GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH Inventor DIMITROV, Dimiter, S.
The invention relates to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and coupled proteins that include the spike protein or a portion thereof; peptidomimetics; vaccines; methods for vaccination and treatment of severe acute respiratory syndrome; antibodies; aptamers; and kits containing immunological compositions, or antibodies (or aptamers) that bind to the spike protein.
3.20100184019Human virus causing severe acute respiratory syndrome (SARS) and uses thereof
US 22.07.2010
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 12703418 Applicant Versitech Limited Inventor Peiris Joseph S. M.

The present invention relates to an isolated novel virus causing Severe Acute Respiratory Syndrome (SARS) in humans (“hSARS virus”). The hSARS virus is identified to be morphologically and phylogenetically similar to known member of Coronaviridae. The present invention provides the complete genomic sequence of the hSARS virus. Furthermore, the invention provides the nucleic acids and peptides encoded by and/or derived from the hSARS virus and their use in diagnostic methods and therapeutic methods, including vaccines. In addition, the invention provides chimeric or recombinant viruses encoded by said nucleotide sequences and antibodies immunospecific to the polypeptides encoded by the nucleotide sequences.

4.111978398Antibody to coronaviruses SARS-CoV-2 and medical application of antibody to coronaviruses SARS-CoV-2
CN 24.11.2020
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No 202010703111.4 Applicant JIANGSU JITRI MEDICAL IMMUNOLOGY TECHNOLOGY RESEARCH INSTITUTE CO., LTD. Inventor YU FENGJIA
The invention relates to an antibody to coronaviruses SARS-CoV-2 and medical application of the antibody to the coronaviruses SARS-CoV-2. The provided SARS-CoV-2 monoclonal antibody which is separatedor does not exist naturally contains heavy chains CDR1, CDR2 and CDR3, which are indicated by Kabat numbering, with sequence identity, which is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, with heavy chains CDR1, CDR2 and CDR3 which are shown in SEQ ID NOS:78 as shown in the description and light chains CDR1, CDR2 and CDR3, which are indicated by Kabat numbering, with sequence identity, which is at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%, with light chains CDR1, CDR2 and CDR3 which are shown in SEQ ID NOS:80 as shown in the description. The antibody can be used as a treatment agent for treating COVID-19 or as a diagnosis tool for assessing COVID-19 infection among subjects.
5.20080081047Anti-SARS monoclonal antibodies
US 03.04.2008
Int.Class A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
Appl.No 10581613 Applicant BERRY JODY Inventor Berry Jody

Monoclonal antibody reagents that recognize the SARS-coronavirus (SARS-HCoV) are needed urgently. In this report we describe the development and immunochemical characterization of mAbs against the SARS-HCoV based upon their specificity, binding requirements, and biological activity. Initial screening by ELISA, using highly purified virus as the coating antigen, resulted in the selection of seventeen mAbs. Five mAbs exhibited Western immunoblot reactivity with the denatured spike protein, of which two demonstrated the ability to neutralize SARS-HCoV in vitro. Another four Western immunoblot-negative mAbs also neutralize the virus. These antibodies will be useful for the development of diagnostic tests, pathogenicity and vaccine studies.

6.WO/2005/044992FUSION INITIATION REGION IN RNA VIRUS ENVELOPE PROTEINS
WO 19.05.2005
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/US2004/036578 Applicant THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND Inventor GARRY, Robert, F.
The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for. viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.
7.20100172917Binding molecules against SARS-coronavirus and uses thereof
US 08.07.2010
Int.Class A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
Appl.No 12590973 Applicant Crucell Holland B.V. Inventor Ter Meulen Jan H.

Described are binding molecules that specifically bind to SARS-CoV, nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules, and methods of identifying or producing the binding molecules. The binding molecules are capable of specifically binding to SARS-CoV, and can be used in the diagnosis, prophylaxis, and/or treatment of a condition resulting from SAR.

8.111995672Coronavirus SARS-COV-2 S protein specific antibody and application thereof
CN 27.11.2020
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No 202010703064.3 Applicant JIANGSU JICUI MEDICAL IMMUNOLOGY TECHNOLOGY RESEARCH INSTITUTE CO., LTD. Inventor WANG YANG
The invention relates to a coronavirus SARS-COV-2 S protein specific antibody and application thereof. The present invention provides an isolated or non-naturally occurring SARS-CoV-2 monoclonal antibody, and the antibody comprises: (a)heavy chains CDR1, CDR2, and CDR3 which are denoted by a Kabat number and have at least 90%,91%,92%,93%,94%,95%,96%,97%,98%,99% or 100% sequence identity with heavychains CDR1, CDR2 and CDR3 shown in the SEQ ID NOS:78, and (b) light chains CDR1, CDR2, CDR3 which are denoted by the Kabat number and has at least 90%,91%,92%,93%,94%,95%,96%,97%,98%,99% or 100% sequence identity of light chain CDR1, CDR2, CDR3 shown in the SEQ ID NOS:80. The antibody of the invention can be used as therapeutic agents for the treatment of COVID-19 or as diagnostic tools for theassessment of COVID-19 infection in a subject.
9.20040071709Corona-virus-like particles comprising functionally deleted genomes
US 15.04.2004
Int.Class A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
Appl.No 10414256 Applicant Inventor Rottier Petrus Josephus Marie

The invention relates to the field of coronaviruses and diagnosis, therapeutics, and vaccines derived thereof. Methods are shown for at least in part inhibiting anti-parallel coiled coil formation of a coronavirus spike protein wherein the methods include decreasing the contact between heptad repeat regions of the protein. The invention provides a peptide including a heptad repeat region of a corona viral spike protein and/or a functional fragment and/or an equivalent thereof. The invention also provides antibodies and inhibiting compounds.

10.112210004Coronavirus COVID-19 detection antibody and application thereof
CN 12.01.2021
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No 202010702938.3 Applicant JIANGSU JITRI INSTITUTE OF MEDICAL IMMUNOLOGY TECHNOLOGY CO., LTD. Inventor WANG YANG
The invention relates to a coronavirus COVID19 detection antibody and application thereof. The isolated or non-existent SARS-CoV-2 monoclonal antibodies contain (a) heavy chains CDR1, CDR2 and CDR3 which are represented by Kabat numbers and have at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity with those of heavy chains CDR1, CDR2 and CDR3 as shown in SEQ ID NOS: 78, and (b) light chains CDR1, CDR2 and CDR3 which are represented by Kabat number and have at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity with those of light chains CDR1, CDR2 and CDR3 as shown in SEQ ID NOS: 80. The antibodies can be used as therapeutic agents for treating COVID-19 or as diagnostic tools for assessing COVID-19 infection in a subject.