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Analysis

1.20210132076MOLECULAR NEIGHBORHOOD DETECTION BY OLIGONUCLEOTIDES
US 06.05.2021
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 17146165 Applicant Board of Regents, The University of Texas System Inventor Edward MARCOTTE

The present disclosure provides methods for molecular neighborhood detection of molecules, such as by iterative proximity ligation or split-and-pool methods for obtaining positional information.

2.20210128532HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
US 06.05.2021
Int.Class A61K 31/4192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41921,2,3-Triazoles
Appl.No 17081940 Applicant GyanRx Sciences, Inc. Inventor Julian A. Codelli

The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.

3.WO/2021/082784GENE EDITING METHOD BASED ON ADENOVIRUS
WO 06.05.2021
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No PCT/CN2020/115644 Applicant NANJING BIOHENG BIOTECH CO., LTD Inventor REN, Jiangtao
Provided is a recombinant adenovirus, which comprises a target expression cassette, a first homologous arm arranged at the 5’ end of the target expression cassette, a second homologous arm arranged at the 3’ end of the target expression cassette, and one or two sgRNA target sequences. The sgRNA target sequence is arranged at the 5’ end of the first homologous arm or the 3’ end of the second homologous arm or is respectively arranged at the 5' end of the first homologous arm and the 3’ end of the second homologous arm. Further provided are a gene editing method based on the recombinant adenovirus, a method for preparing a gene-edited animal, a method for preparing engineered T cells, and a system, composition and kit comprising the recombinant adenovirus.
4.WO/2021/083429CODON-OPTIMIZED GLUCOSE OXIDASE GENE AND APPLICATION THEREOF
WO 06.05.2021
Int.Class C12N 15/53
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
53Oxidoreductases (1)
Appl.No PCT/CN2020/140668 Applicant BIOLOGY INSTITUTE OF SHANDONG ACADEMY OF SCIENCES Inventor GONG, Weili
The invention provides a codon-optimized glucose oxidase gene. The gene is derived from Aspergillus niger An76, and the sequence thereof is as shown in SEQ ID No. 2. The initial glucose oxidase gene cannot be successfully expressed in Pichia pastoris, but can be successfully expressed in Pichia pastoris following sequence optimization. In addition, a purified target protein can be obtained by means of separation and purification, and the recombinant glucose oxidase may be used in glucose biosensors.
5.WO/2021/085454METHOD FOR PRODUCING BIOCHIPS
WO 06.05.2021
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2020/040370 Applicant TORAY INDUSTRIES, INC. Inventor KOSHI, Yoichiro
Disclosed is a method for producing biochips, said method comprising immobilizing a selective binding substance on the surface of a substrate through a condensation reaction using a spotting solution that contains a condensing agent, wherein the quality of a spot can be examined using the deposition of a salt thereof as an indicator and thus biochips with guaranteed qualities can be produced. This method for producing biochips comprises: step A for applying to the surface of a substrate a solution that contains a selective binding substance, a salt and a condensing agent; step B for allowing the selective binding substance to bind to the surface of the substrate; step C for drying the applied solution to cause the deposition of the salt in the solution on the surface of the substrate; and step D for detecting the salt having been deposited in step C with the use of an image detection device, wherein, in step A, the concentration of the condensing agent in the solution is 30-80 mM inclusive.
6.WO/2021/083204KERATIN BD-14, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
WO 06.05.2021
Int.Class C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Appl.No PCT/CN2020/124365 Applicant INSTITUTE OF MATERIA MEDICA , CHINESE ACADEMY OF MEDICAL SCICENCES Inventor YU, Shishan
Provided are keratin BD-14, a nucleic acid molecule encoding keratin BD-14, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrated with the nucleic acid molecule, a preparation method for keratin BD-14, a pharmaceutical composition containing keratin BD-14, and an application of said keratin BD-14, nucleic acid molecule, expression vector, host cell, or pharmaceutical composition in preparing antipyretic and analgesic, antitussive and expectorant, anticonvulsant, antiepileptic, blood pressure lowering, anti-inflammatory and antiviral drugs.
7.WO/2021/086219LIGHT-GATED PENTAMERIC CHANNEL - A NEW OPTOGENETIC TOOL
WO 06.05.2021
Int.Class C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Appl.No PCT/RU2019/000776 Applicant FORSCHUNGSZENTRUM JÜLICH, INSTITUTE OF COMPLEX SYSTEMS Inventor BRATANOV, Dmitry Olegovich
The invention relates to newly characterized light-gated pentameric channels such as OLPVRII and their use in medicine, their utility as optogenetic tools, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells expressing said light-gated pentameric channels and their respective uses.
8.WO/2021/086444FLUID PREPARATION DEVICES
WO 06.05.2021
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
Appl.No PCT/US2020/032202 Applicant HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. Inventor CHOY, Si-lam J.
A fluid preparation device can include a fluid-receiving vessel and a fluid loader with multiple fluid chambers including a first fluid chamber and a second fluid chamber. The multiple fluid chambers can partially be defined by actuator seals that are positioned on an actuator. The actuator can be moveable among a plurality of positions and the actuator seals can be positioned on the actuator to fluidically separate the first fluid chamber from the second fluid chamber when the actuator is in a closed position from the plurality of positions, allow fluidic communication between the second fluid chamber and the fluid-receiving vessel when the actuator is in a first open position from the plurality of positions, and allow fluidic communication between the first fluid chamber and the second fluid chamber when the actuator is in a second open position from the plurality of positions.
9.WO/2021/086954METHODS AND DEVICES USING CARTRIDGES FOR SEQUENCING
WO 06.05.2021
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/US2020/057722 Applicant QUANTUM-SI INCORPORATED Inventor ROTHBERG, Jonathan M.
Methods and devices for enriching and analyzing target molecules from a sample are provided herein. In some embodiments, methods and devices using cartridges involve enrichment of target molecules (e.g., using SCODA) and detection and analysis using sequencing. The method may employ lysing of cells, fragmentation of target in the sample preparation module and enriching the target in the module and moving the target to the sequencing module.
10.WO/2021/087164METHODS FOR DETECTING OLIGONUCLEOTIDES
WO 06.05.2021
Int.Class C12N 9/22
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
Appl.No PCT/US2020/058044 Applicant SHIRE HUMAN GENETIC THERAPIES, INC. Inventor SHEN, Yinghua
The present disclosure describes methods for detecting oligonucleotide presence and/or quantity in a sample.