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Analysis

1.20210132076MOLECULAR NEIGHBORHOOD DETECTION BY OLIGONUCLEOTIDES
US 06.05.2021
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 17146165 Applicant Board of Regents, The University of Texas System Inventor Edward MARCOTTE

The present disclosure provides methods for molecular neighborhood detection of molecules, such as by iterative proximity ligation or split-and-pool methods for obtaining positional information.

2.20210128532HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
US 06.05.2021
Int.Class A61K 31/4192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41921,2,3-Triazoles
Appl.No 17081940 Applicant GyanRx Sciences, Inc. Inventor Julian A. Codelli

The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.

3.20210130789METHODS OF STROMAL CELL EXPANSION, USES AND MATERIALS RELATED THERETO
US 06.05.2021
Int.Class C12N 5/0775
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
Appl.No 17082642 Applicant CITY OF HOPE Inventor Ismail H. AL-ABDULLAH

Disclosed herein are methods for expanding and potentiating intra-pancreatic tissue-derived mesenchymal stromal/stem cells in the presence of TNF-α, DMOG, or both, to obtain IPTD-MSCs having enhanced pro-angiogenic and/or anti-inflammatory properties. Also disclosed are therapeutic applications of these IPTD-MSCs.

4.20210130769Method for Single Cell Encapsulation via Metabolic Glycoengineering and Copper-Free Click Chemistry
US 06.05.2021
Int.Class C12N 5/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Appl.No 17090064 Applicant The Board of Trustees Of the Leland Stanford Junior University Inventor Byeongtaek Oh

A method of single-cell encapsulation of cells using glycoengineering and click-chemistry is provided. Cells are treated with a precursor for metabolic engineering to modify glycans in a cell membrane and form reactive component A-glycans in the cell membrane suitable for a click-chemistry reaction. The treated cells are suspended in a polymer solution which has a reactive component B suitable for the click-chemistry reaction. The reactive component A-glycans react via the click-chemistry with the reaction component B thereby forming single cell polymer encapsulated cells. Applications include optimizing stem cell function, cell to cell crosslinking, formation of networks of cells or organoids, functionalizing the cells with reactive groups or attaching the cells to a substrate or surface.

5.WO/2021/082784GENE EDITING METHOD BASED ON ADENOVIRUS
WO 06.05.2021
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No PCT/CN2020/115644 Applicant NANJING BIOHENG BIOTECH CO., LTD Inventor REN, Jiangtao
Provided is a recombinant adenovirus, which comprises a target expression cassette, a first homologous arm arranged at the 5’ end of the target expression cassette, a second homologous arm arranged at the 3’ end of the target expression cassette, and one or two sgRNA target sequences. The sgRNA target sequence is arranged at the 5’ end of the first homologous arm or the 3’ end of the second homologous arm or is respectively arranged at the 5' end of the first homologous arm and the 3’ end of the second homologous arm. Further provided are a gene editing method based on the recombinant adenovirus, a method for preparing a gene-edited animal, a method for preparing engineered T cells, and a system, composition and kit comprising the recombinant adenovirus.
6.WO/2021/083429CODON-OPTIMIZED GLUCOSE OXIDASE GENE AND APPLICATION THEREOF
WO 06.05.2021
Int.Class C12N 15/53
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
53Oxidoreductases (1)
Appl.No PCT/CN2020/140668 Applicant BIOLOGY INSTITUTE OF SHANDONG ACADEMY OF SCIENCES Inventor GONG, Weili
The invention provides a codon-optimized glucose oxidase gene. The gene is derived from Aspergillus niger An76, and the sequence thereof is as shown in SEQ ID No. 2. The initial glucose oxidase gene cannot be successfully expressed in Pichia pastoris, but can be successfully expressed in Pichia pastoris following sequence optimization. In addition, a purified target protein can be obtained by means of separation and purification, and the recombinant glucose oxidase may be used in glucose biosensors.
7.WO/2021/084111COLIPHAGES AND USES THEREOF
WO 06.05.2021
Int.Class C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
Appl.No PCT/EP2020/080600 Applicant INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Inventor PETIT, Marie-Agnès
The present invention relates to bacteriophages and their use in therapy. More particularly, the present invention relates to novel bacteriophages having a lytic against Escherichia coli strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.
8.WO/2021/084494NOVEL PEPTIDES AND USES THEREOF FOR TREATING CANCER
WO 06.05.2021
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No PCT/IB2020/060207 Applicant SYMTHERA CANADA LTD. Inventor EZERZER, Chai
Presented herein are cancer peptide agents and uses thereof for treating cancer and/or inhibiting metastasis. Also presented herein are methods of treating cancer, or inhibiting metastasis of cancer in a subject, comprising administering a therapeutically effective amount of a composition comprising one or more cancer peptide agents to the subject. Also presented herein is a method of treating a cancer in a subject, or inhibiting metastasis of a cancer in a subject that comprises administering a therapeutically effective amount of a composition comprising one or more cancer peptide agents, and administering a chemotherapy or chemotherapeutic agent.
9.WO/2021/084869MANUFACTURING METHOD FOR MICROBUBBLE-CONTAINING ELECTROLYTE AND MANUFACTURING METHOD FOR MICROBUBBLE-CONTAINING SOLVENT FOR USE IN PREPARING MICROBUBBLE-CONTAINING ELECTROLYTE
WO 06.05.2021
Int.Class A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Appl.No PCT/JP2020/031887 Applicant AICHI MEDICAL UNIVERSITY Inventor HATAYAMA Naoyuki
Provided are: a manufacturing method for an electrolyte that can contain microbubbles at a high concentration by suppressing a reduction in microbubbles during filtering; and a manufacturing method for a microbubble-containing solvent that can be used to prepare the electrolyte. This manufacturing method for a microbubble-containing electrolyte includes a filtering process in which a microbubble-containing solvent is filtered using a filtering material, and a preparation step in which an electrolyte is prepared from the obtained filtrate, wherein the positive ion concentration in the microbubble-containing solvent is less than 20 mmol/L, and at least one of the following conditions (1), (2), and (3) is met. Condition (1): the density of microbubbles in the microbubble-containing solvent is at least 1 × 106 bubbles/mL. Condition (2): a solvent preparation step is included in which microbubbles are introduced into a solvent and a microbubble-containing solvent is prepared. Condition (3): the density of microbubbles in the electrolyte is at least 1 × 105 bubbles/mL.
10.WO/2021/085034METHOD FOR SELECTING PLURIPOTENT STEM CELLS, METHOD FOR PREDICTING RESULT OF DIFFERENTIATION INDUCTION, AND METHOD FOR PRODUCING CELL PRODUCT
WO 06.05.2021
Int.Class G01N 21/17
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
Appl.No PCT/JP2020/037591 Applicant FUJIFILM CORPORATION Inventor MURAKAMI, Yuta
A method for selecting pluripotent stem cells, said method comprising: from a hologram obtained by imaging an aggregate of pluripotent stem cells, generating a phase difference image of the aggregate; on the basis of the phase difference image, deriving an indicator value, which is determined depending on the relationship between the area of the aggregate and the outline length thereof and which indicates the complexity or simplicity of the outline; and then selecting the pluripotent cells on the basis of the indicator value.