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Analysis

1.20210132076MOLECULAR NEIGHBORHOOD DETECTION BY OLIGONUCLEOTIDES
US 06.05.2021
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 17146165 Applicant Board of Regents, The University of Texas System Inventor Edward MARCOTTE

The present disclosure provides methods for molecular neighborhood detection of molecules, such as by iterative proximity ligation or split-and-pool methods for obtaining positional information.

2.20210128619USES OF ANTI-BCMA CHIMERIC ANTIGEN RECEPTORS
US 06.05.2021
Int.Class A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Appl.No 17089594 Applicant CELGENE CORPORATION Inventor Timothy CAMPBELL

Provided herein are uses of anti-B cell maturation antigen (BCMA) chimeric antigen receptors (CARs) for treating B-cell related conditions, such as BCMA-expressing cancers.

3.WO/2021/084089ANALYSIS OF PROTEIN TERMINI
WO 06.05.2021
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No PCT/EP2020/080549 Applicant CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL Inventor HELBIG, Andreas
The invention provides a process for analysis of terminal sections of proteins comprising the steps of - providing one original isolated protein or a mixture of at least 2 original proteins, - digesting the original protein or mixture of original proteins by one exopeptidase, which is a carboxypeptidase or an aminopeptidase, to generate terminal peptide sections of the isolated protein or of the mixture of proteins, and free amino acids, - separating the terminal peptide sections from the free amino acids, - determining the masses, and preferably additionally determining fragmentation spectra, of the terminal peptide sections by mass spectrometry, preferably by ESI-MS/MS, and - comparing the determined masses, and preferably comparing the fragmentation spectra, to pre-determined masses of peptides to identify the amino acid sequences of the terminal peptide sections, - from the determined masses identifying terminal peptide sections - and assigning the terminal peptide sections having the same sequence of terminal amino acids to an individual group, and for the individual group classifying the terminal peptide sequences as belonging to one individual terminus of an original protein each.
4.WO/2021/084419METHOD FOR MAPPING ROLLING CIRCLE AMPLIFICATION PRODUCTS
WO 06.05.2021
Int.Class C12Q 1/6816
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
Appl.No PCT/IB2020/060062 Applicant PIXELGEN TECHNOLOGIES AB Inventor FREDRIKSSON, Simon
Provided herein is a method for mapping rolling circle amplification (RCA) products that contain unique identifier sequences. The method generally involves (a) producing a complex comprising population of grid oligonucleotide molecules and a population of RCA products that each have a unique RCA product identifier sequence, wherein the grid oligonucleotides are hybridized directly or indirectly via a splint to complementary sites in the RCA products; (b) extending the grid oligonucleotide molecules that are hybridized to two RCA products to add the complements of the unique RCA product identifier sequences from the two RCA products to the grid oligonucleotide molecules; (c) sequencing the extended grid oligonucleotides; (d) analyzing the sequences to identify which pairs of unique RCA product identifier sequence complements have been added onto the grid oligonucleotides; and (e) making one or more physical maps of the immobilized RCA products using the pairs of sequences identified in (d).
5.WO/2021/084539A METHOD FOR DETERMINING BACTERIAL SUSCEPTIBILITY TO ANTIBIOTICS
WO 06.05.2021
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/IL2020/051129 Applicant THE ISRAEL INSTITUTE OF BIOLOGICAL RESEARCH (IIBR) Inventor ALONI-GRINSTEIN, Ronit
The invention concerns methods for determining antimicrobial susceptibility of a microorganism (e.g. bacteria, fungi), comprising incubating a biological or environmental sample on a solid growth substrate containing at least one antimicrobial agent at varying concentrations for a relatively short period of time; recovering the microorganism growing on the solid growth substrate surface; and determining the microorganism quantity using a quantitative method, e.g. qPCR, and comparing the quantity to that of a sample grown on a solid substrate without antimicrobial agent. The method is particularly useful for Yersinia pestis, Bacillus anthracis and Francisella tularensis.
6.WO/2021/085454METHOD FOR PRODUCING BIOCHIPS
WO 06.05.2021
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
Appl.No PCT/JP2020/040370 Applicant TORAY INDUSTRIES, INC. Inventor KOSHI, Yoichiro
Disclosed is a method for producing biochips, said method comprising immobilizing a selective binding substance on the surface of a substrate through a condensation reaction using a spotting solution that contains a condensing agent, wherein the quality of a spot can be examined using the deposition of a salt thereof as an indicator and thus biochips with guaranteed qualities can be produced. This method for producing biochips comprises: step A for applying to the surface of a substrate a solution that contains a selective binding substance, a salt and a condensing agent; step B for allowing the selective binding substance to bind to the surface of the substrate; step C for drying the applied solution to cause the deposition of the salt in the solution on the surface of the substrate; and step D for detecting the salt having been deposited in step C with the use of an image detection device, wherein, in step A, the concentration of the condensing agent in the solution is 30-80 mM inclusive.
7.WO/2021/086954METHODS AND DEVICES USING CARTRIDGES FOR SEQUENCING
WO 06.05.2021
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/US2020/057722 Applicant QUANTUM-SI INCORPORATED Inventor ROTHBERG, Jonathan M.
Methods and devices for enriching and analyzing target molecules from a sample are provided herein. In some embodiments, methods and devices using cartridges involve enrichment of target molecules (e.g., using SCODA) and detection and analysis using sequencing. The method may employ lysing of cells, fragmentation of target in the sample preparation module and enriching the target in the module and moving the target to the sequencing module.
8.WO/2021/087344THERANOSTICS FOR HYPERTENSION INDUCED MYOCARDIAL MICROBLEEDS
WO 06.05.2021
Int.Class C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Appl.No PCT/US2020/058335 Applicant CEDARS-SINAI MEDICAL CENTER Inventor DHARMAKUMAR, Rohan
The invention relates to methods of cardiovascular imaging and/or measurement of blood markers for detecting, diagnosing and/or prognosing cardiac or myocardial microbleeds, especially in subject with hypertension and cardiovascular diseases. Treatment methods are also provided for subjects identified, diagnosed, prognosed, or detected with cardiac or myocardial microbleeds. In some embodiments, the subject has hypertension-induced microbleeds, but has not had a myocardial infarction or reperfusion therapy.
9.20210130790Infected Cell Cultures
US 06.05.2021
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
Appl.No 16492071 Applicant Merck Patent GmbH Inventor Thomas Spangenberg

3D cell cultures contain hepatic cells and are infected by a pathogen. Such cell cultures are prepared by, for example, inoculating a single-cell suspension containing hepatic cells expanded in a 2D culture in an agitation-based culture system. Next, the resulting cell culture is agitated at a given agitation rate. Then, the resulting 3D cell culture containing cell aggregates is incubated with a pathogen.

10.20210131994ENGINEERING CARBON-BASED STRUCTURES FOR SENSING APPLICATIONS
US 06.05.2021
Int.Class G01N 27/30
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
Appl.No 16635634 Applicant NEW YORK UNIVERSITY Inventor Davood SHAHRJERDI

Principles for reliable manufacturing carbon-based electrodes with arbitrary sensitivity and homogeneity are provided. Specifically, the sensitivity of carbon-based electrodes can be engineered by changing the density of sp2 type defects present in a multilayer graphene film. The engineered carbon-based electrodes can be used as a passive sensing element in electrochemical measurement of a target analyte. Carbon-based electrodes are also disclosed that have sp2 hybridization and can include multilayer graphene films. The disclosed carbon-based electrodes have a density of zero-dimensional defects (i.e., point-like defects) which provides enhanced area-normalized sensitivity when used in sensing applications. The maximum area-normalized sensitivity is achieved at the point defect density of 4-5×1012 cm−2.