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Analysis

1.WO/2021/083384LOW MOLECULAR WEIGHT CHONDROITIN SULFATE, COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF
WO 06.05.2021
Int.Class C12P 19/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
14produced by the action of a carbohydrase, e.g. by alpha-amylase
Appl.No PCT/CN2020/126003 Applicant NANJING XINLANG ENTERPRISE MANAGEMENT CONSULTING CO.,LTD. Inventor ZHANG, Haoning
Disclosed are a low molecular weight chondroitin sulfate and a preparation method therefor. The method comprises: using a macromolecular chondroitin sulfate as a raw material, and subjecting same to production processes of chondroitin sulfate lyase degradation, deproteinization, filtration, sterilization, drying, etc., so as to obtain a low molecular weight chondroitin sulfate with an average molecular weight less than 1000 daltons. The chondroitin sulfate has a narrow molecular weight distribution range, wherein chondroitin sulfate disaccharides account for 43-60%; chondroitin sulfate tetrasaccharides account for 30-45%; the sum of the content of chondroitin sulfate disaccharides and chondroitin sulfate tetrasaccharides is greater than 87%; the total content of oligosaccharides in the low molecular weight chondroitin sulfate is at least 97%; and the content of protein does not exceed 0.5%. Compared with common commercially available macromolecular chondroitin sulfate, the product has a more obvious repair effect on chondrocytes damaged by 1 mM hydrogen peroxide within the concentration of 50-100 μg/mL. The product has a strong repair ability with a repair rate between 14% and 23%, and can be used to treat joint injuries and is an important raw material for medical products, health care products, cosmetics, foods, etc.
2.20210128743TRANSGLUTAMINASE CONJUGATION METHOD AND LINKER
US 06.05.2021
Int.Class A61K 47/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
Appl.No 16648636 Applicant Paul Schemer institut Inventor Philipp Spycher

The present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (MTG). The method comprises a step of conjugating a linker having a primary amine residue, said linker having the peptide structure (shown in N->C direction) (Aax)m-(Aax)(NH2)-(Aax)n-B-(Aax)o, or (Aax)m-B-(Aax)n-(Aax)(NH2)-(Aax)o, to a Gln residue comprised in the heavy or light chain of an antibody. Aax(NH2) is an amino acid, amino acid derivative or amino acid mimetic comprising a side chain having a primary amine group.

3.WO/2021/082440METHOD FOR PRODUCING XYLOOLIGOSACCHARIDE UNDER CATALYSIS OF XYLONIC ACID
WO 06.05.2021
Int.Class C12P 19/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
Appl.No PCT/CN2020/093889 Applicant NANJING FORESTRY UNIVERSITY Inventor XU, Yong
Disclosed in the present invention is a method for producing xylooligosaccharide under catalysis of a xylonic acid. The method for producing xylooligosaccharide using a xylonic acid comprises: mixing a xylan raw material and the xylonic acid, and performing heating and stirring to undergo a reaction to obtain xylooligosaccharide, in parts by mass, the xylan raw material being 1 part, and the xylonic acid being 5-12 parts. The method for producing xylooligosaccharide by fermentation under catalysis comprises: mixing xylose and bacteria to obtain a mixed liquid; adjusting the pH of the mixed liquid; stirring at a low temperature to undergo a biological oxidation reaction; and adding a xylan raw material, and performing heating and stirring to obtain xylooligosaccharide. The present invention utilizes the reaction of microbial whole cell biological oxidation of the xylose to the xylonic acid, and uses the produced xylonic acid as a catalyst; compared with acetic acid and other inorganic acids, the produced glycan is not easily excessively degraded, and has a high yield and less by-product xylose furfural.
4.WO/2021/085530BIOMASS TREATMENT METHOD AND BIOMASS TREATMENT EQUIPMENT
WO 06.05.2021
Int.Class B09B 3/00
BPERFORMING OPERATIONS; TRANSPORTING
09DISPOSAL OF SOLID WASTE; RECLAMATION OF CONTAMINATED SOIL
BDISPOSAL OF SOLID WASTE
3Destroying solid waste or transforming solid waste into something useful or harmless
Appl.No PCT/JP2020/040622 Applicant KOBELCO ECO-SOLUTIONS CO., LTD. Inventor AKASHI, Akira
Provided is a biomass treatment method comprising: a pretreatment step in which, in a substance to be treated containing biomass that includes refractory organic matter and rumen microorganisms that are derived from a ruminant animal, easily fermented constituents are produced from the refractory organic matter; a methane fermentation step in which at least part of the substance to be treated containing the easily fermented constituents is subjected to dry methane fermentation treatment; and a fermentation residue feeding step in which at least part of fermentation residue produced in the methane fermentation step is fed to the substance to be treated in the pretreatment step.
5.WO/2021/086010FRUCTOSE-6-PHOSPHATE 3-EPIMERASE AND USE THEREOF
WO 06.05.2021
Int.Class C12N 9/90
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
90Isomerases (5.)
Appl.No PCT/KR2020/014808 Applicant SAMYANG CORPORATION Inventor HEO, Jinsol
The present invention relates to an epimerase protein of fructose-6-phosphate, nucleic acid molecules for encoding the epimerase protein, a recombinant vector and a transgenic microorganism which comprise the nucleic acid molecules, and a composition for producing allulose by using same.
6.20210128654COMPOSITION FOR TREATING, PREVENTING, OR IMPROVING MALE INFERTILITY
US 06.05.2021
Int.Class A61K 36/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
06Fungi, e.g. yeasts
Appl.No 17137703 Applicant Mugen General Incorporated Association Inventor Masahiro Yamamoto

Provided is a composition for use in medicines, food products, supplements, or beverages that can treat, prevent, or improve male infertility. The composition for treating, preventing, or improving male infertility of the present invention contains a koji mold fermentation product obtained by fermentation with a koji mold.

7.WO/2021/085794STRAIN HAVING IMPROVED AROMATIC AMINO ACID PRODUCTION CAPABILITY DUE TO YEEO GENE INACTIVITY
WO 06.05.2021
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
Appl.No PCT/KR2020/008405 Applicant DAESANG CORPORATION Inventor SHIN, Won Joo
Disclosed is a mutant strain having an improved aromatic amino acid production capability due to the weakening or inactivation of the activity of an FMN/FAD transport protein which is expressed by the yeeO gene.
8.WO/2021/085854YEAST STRAIN THAT PRODUCES GLUTATHIONE, AND GLUTATHIONE PRODUCTION METHOD USING SAME
WO 06.05.2021
Int.Class C12N 1/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
16Yeasts; Culture media therefor
Appl.No PCT/KR2020/012614 Applicant CJ CHEILJEDANG CORPORATION Inventor HA, Cheol Woong
The present application relates to a novel yeast strain that produces glutathione, and a glutathione production method using same.
9.WO/2021/081999LOW-MOLECULAR-WEIGHT CHONDROITIN SULFATE AND PREPARATION METHOD THEREFOR
WO 06.05.2021
Int.Class C12P 19/14
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
14produced by the action of a carbohydrase, e.g. by alpha-amylase
Appl.No PCT/CN2019/115120 Applicant NANJING HANXIN PHARMACEUTICAL TECHNOLOGY CO. LTD. Inventor WANG, Yin
Disclosed are a low-molecular-weight chondroitin sulfate and a preparation method therefor. Macromolecular chondroitin sulfate is used as a raw material. A low-molecular-weight chondroitin sulfate having an average molecular weight of less than 1000 daltons can be obtained by means of a production process comprising chondroitin sulfate lyase degradation, deproteinization, filtration sterilization, drying, etc. With respect to the low-molecular-weight chondroitin sulfate, the molecular weight distribution range is narrow, the proportion of chondroitin sulfate disaccharide is 43% to 60%, the proportion of chondroitin sulfate tetrasaccharide is 30% to 45%, the sum of the contents of the chondroitin sulfate disaccharide and the chondroitin sulfate tetrasaccharide is greater than 87%, the total content of oligosaccharides in the low-molecular-weight chondroitin sulfate is not less than 97%, and the protein content is not more than 0.5%. Compared with common marketed macromolecular chondroitin sulfate, the product has, at a concentration of 50 μg/mL to 100 μg/mL, a more obvious repairing effect on chondrocytes damaged by 1 mM hydrogen peroxide, has a strong repairing ability and a repair rate between 14% and 23%, and can be used to treat joint injuries, and same is thus an important raw material for medical products, healthcare products, cosmetics, food product, etc.
10.WO/2021/083079LONG-CHAIN COMPOSITION, COMBINATION OF LONG-CHAIN COMPOSITION, MANUFACTURING METHOD, AND APPLICATION THEREOF
WO 06.05.2021
Int.Class C12N 1/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
14Fungi ; Culture media therefor
16Yeasts; Culture media therefor
Appl.No PCT/CN2020/123700 Applicant CHINA PETROLEUM & CHEMICAL CORPORATION Inventor ZHANG, Lin
Provided are a long-chain composition or a combination of long-chain composition, a manufacturing method thereof, and an application thereof in manufacturing a long-chain diacid by a fermentation method. The long-chain composition comprises at least one long-chain alkane selected from C9-18 straight or branched chain alkanes and at least one long-chain carboxylic acid selected from C9-18 straight or branched, saturated or unsaturated aliphatic monocarboxylic acids, where a mass ratio of the long-chain alkane to the long-chain carboxylic acid is 1:1 to 40:1. When the long-chain composition is used as a raw material to produce the long-chain diacid by the fermentation method, the advantages of higher fermentation level, higher substrate utilization, etc., are exhibited.