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Analysis

1.2822295Métodos y reactivos para el diagnóstico de la infección por SARS-CoV-2
ES 30.04.2021
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 21158065 Applicant Euroimmun Medizinische Labordiagnostika AG Inventor STEINHAGEN, Katja
2.112684060新型冠状病毒灭活疫苗中新型冠状病毒S蛋白含量的检测方法
CN 20.04.2021
Int.Class G01N 30/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
Appl.No 202110052933.5 Applicant 北京生物制品研究所有限责任公司 Inventor 王辉
本发明提供新型冠状病毒灭活疫苗中新型冠状病毒S蛋白含量的检测方法。该检测方法利用了本发明的定量肽段(GWIFGTTLDSK);定量肽段的离子对中母离子的质荷比为612.8161,子离子的质荷比为244.1080和/或216.1080。利用该定量肽段和定量离子对,通过高效液相色谱串联质谱定量检测方法,S蛋白标准品制作标准曲线,将待测新冠病毒疫苗孵育酶解后进行定量检测,得到样品中定量肽段的子离子峰面积,进而计算得到样品中新型冠状病毒S蛋白的含量。该方法检测准确率高,精确度高,避免了疫苗样品中基质效应等对检测的影响,能够用于新冠病毒灭活疫苗各阶段中间产品及成品的新冠病毒S蛋白含量检测。
3.112679587易于激活B细胞的重组抗原蛋白及其制备方法
CN 20.04.2021
Int.Class C07K 14/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
Appl.No 202011507132.5 Applicant 河南中泽生物工程有限公司 Inventor 张改平
本发明涉及易于激活B细胞的重组抗原蛋白及其制备方法。本发明提供的重组抗原蛋白将两个或两个以上至少含有一个相同抗原表位肽的抗原蛋白通过连接肽连接起来,制备成二聚体或多聚体重组抗原,其中,所述连接肽的长度需要使至少两个相同抗原表位之间的距离处在3‑50nm之间。该重组抗原能够使得抗原蛋白的相同抗原表位中至少两个同时被B细胞上的BCR识别,导致BCR被交联,从而更有效的激活B细胞。本发明还提供了上述重组蛋白抗原的制备方法,该方法具有普适性,能够获得B细胞激活效率显著提高的重组抗原,可广泛应用于疫苗抗原制备、抗体制备等领域。
4.112661819新型冠状病毒RBD的重组病毒样颗粒及其构建方法
CN 16.04.2021
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202110031257.3 Applicant 军事科学院军事医学研究院军事兽医研究所 Inventor 金宁一
本发明涉及生物医学领域,特别涉及新型冠状病毒RBD的重组病毒样颗粒及其构建方法。本发明将SARS‑CoV‑2RBD序列插入至乙肝核心抗原序列,连接至pFastBacDual载体,转化到DH10Bac感受态细胞后获得重组杆粒。将重组杆粒转染至sf9细胞后进行病毒拯救,获得重组杆状病毒。PCR及WesternBlot结果显示,重组杆状病毒构建成功并且可以表达外源蛋白RBD‑HBc。透射电镜观察结果显示,电镜下可以看到40nm左右的病毒样颗粒,表明本研究成功构建了呈现SARS‑CoV‑2RBD的病毒样颗粒,为后期疫苗的研究奠定了基础。
5.112646005多肽、多肽疫苗及应用
CN 13.04.2021
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202011625769.4 Applicant 珠海碳云智能科技有限公司 Inventor 王健
本发明提供了多肽、多肽疫苗、抗原表位的筛选方法及应用。其中,多肽为SEQ ID NO:1至SEQ ID NO:154,尤其是SEQ ID NO:1至SEQ ID NO:40所示的40条肽段。通过创新性地结合多肽芯片技术筛选获得40条与冠状病毒感染,尤其是SARS‑Cov‑2病毒感染特异性相关的多肽,这些多肽能够被用来制备多肽疫苗、核酸疫苗、蛋白重组疫苗等相关疫苗产品,从而为防控此类病毒的传染和流行提供更有力的工具。
6.112646006一种用于COVID-19轻重症分型诊断的标志物抗原表位多肽及其应用
CN 13.04.2021
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202110077494.3 Applicant 中国人民解放军陆军军医大学 Inventor 张怡
本发明公开了本发明提供了一种用于COVID‑19轻重症分型诊断的抗原表位多肽,其特征在于,所述抗原表位多肽为SEQ ID NO:1或SEQ ID NO:2。本发明同时还提供了基于上述抗原表位多肽制备的探针以及用于COVID‑19轻重症分型的诊断试剂。本发明提供的抗原表位多肽与轻重症患者血清中的IgG反应后显示出显著不同的丰度,可用于对COVID‑19轻重症患者的快速诊断分型。
7.112625096一种禽传染性支气管炎病毒样颗粒及其制备方法与应用
CN 09.04.2021
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202110049762.0 Applicant 广西大学 Inventor 磨美兰
本发明公开了一种禽传染性支气管炎病毒样颗粒,所述病毒样颗粒由IBV‑S、IBV‑M、IBV‑E基因分别转入到杆状病毒表达系统中,获得3种重组杆粒,再分别将3种重组杆粒转染到昆虫细胞中,获得重组杆状病毒rHBM‑S、rHBM‑M和rHBM‑E,然后通过共感染的形式,初步构建得到,该病毒样颗粒应用于制备疫苗中,具有巨大的开发潜力。
8.112626089一种SARS-CoV-2病毒S蛋白受体结合区域编码基因、抗体及应用
CN 09.04.2021
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 202011445642.4 Applicant 杭州百凌生物科技有限公司 Inventor 潘丽
本发明公开了一种SARS‑CoV‑2病毒S蛋白受体结合区域编码基因表达的重组蛋白、其产生的抗体及应用,属于生物医学领域及免疫学检测领域。所述编码基因具有SEQ ID NO:2所示的核苷酸序列。所述编码基因或抗体可应用于制备检测抗SARS‑CoV‑2病毒S蛋白受体结合区域抗体。本发明公开了利用所述编码基因表达的重组蛋白制备的抗体及其应用。本发明的编码基因保证了蛋白表达的唯一性,减少了蛋白后续纯化的难度。制备的抗体检测抗原的灵敏度高、特异性强。
9.112618707一种SARS-CoV-2冠状病毒疫苗及其制备方法
CN 09.04.2021
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202011103983.3 Applicant 广州达博生物制品有限公司 Inventor 黄文林
本发明公开了一种SARS‑CoV‑2冠状病毒的疫苗及其制备方法,通过对SARS‑CoV‑2冠状病毒的S基因进行密码子优化,并将S基因的截短体及突变体序列导入分泌型缺陷型腺病毒载体,包装得到相应重组腺病毒。该重组腺病毒能够在体内表达SARS‑CoV‑2病毒相关蛋白,并完成加工、折叠、糖基化等修饰,基本上保持S蛋白的天然构象,具有生物活性高、半衰期长、免疫原性持久等特点。本品采用的携带分泌肽的缺陷型腺病毒载体使重组腺病毒疫苗在体内表达后,能被分泌至细胞外,从而激活体液免疫。
10.112630427一种基于S1蛋白的检测流行QX型鸡传染性支气管病毒抗体的间接免疫荧光试剂盒
CN 09.04.2021
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 202011371468.3 Applicant 扬州大学 Inventor 叶建强
本发明公开了一种基于S1蛋白的检测流行QX型鸡传染性支气管病毒抗体的间接免疫荧光试剂盒,该试剂盒包括表达S1蛋白的LMH细胞,FITC标记的羊抗鸡抗体,样品稀释液,洗涤液。本发明试剂盒具有良好的特异性;该试剂盒不仅能用于QX型鸡传染性支气管病毒感染状况流行病学调查,而且能有效用于监测免疫鸡群QX型鸡传染性支气管病毒抗体水平,用于评价免疫保护性抗体水平等。