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Analysis

1.20210128532HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
US 06.05.2021
Int.Class A61K 31/4192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41921,2,3-Triazoles
Appl.No 17081940 Applicant GyanRx Sciences, Inc. Inventor Julian A. Codelli

The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.

2.20210130377BETA-PHOSPHONYL-ENAMINE DERIVATIVE AND PREPARATION METHOD THEREFOR
US 06.05.2021
Int.Class C07F 9/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
50Organo-phosphines
Appl.No 17146466 Applicant SOOCHOW UNIVERSITY Inventor Jianping ZOU

The present invention discloses the preparation method of β-phosphonyl-enamine derivative. The preparation method comprising the following steps: dissolving the enamine derivative, organic phosphine compound, manganese acetate and potassium carbonate in the solvent, reacting at room temperature to obtain the β-phosphonyl-enamine derivative. The enamine derivative was as the starting material, and the raw materials are easy to obtain and a great many varieties. The various forms of the products obtained therein can be directly applied and can be used in further reactions. The reaction conditions are mild, the reaction speed is high, the reaction operation and the post-treatment process are simple, the production is convenient, and the method is suitable for large-scale production.

3.20210130473TGFßR1 INHIBITOR-ASGR ANTIBODY CONJUGATES AND USES THEREOF
US 06.05.2021
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No 17066897 Applicant Silverback Therapeutics, Inc. Inventor Peter R. BAUM

Various conjugates and compositions thereof are disclosed for use in the treatment of a liver disease, such as liver cancer and liver fibrosis. The compositions comprise conjugates, wherein the conjugates are comprised of an antibody or antibody construct specific for ASGR1 or ASGR2 attached to a TGFβR1 inhibitor via a linker. Additionally provided are the methods of preparation of the conjugates and compositions thereof.

4.20210135111ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
US 06.05.2021
Int.Class H01L 51/00
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
LSEMICONDUCTOR DEVICES; ELECTRIC SOLID STATE DEVICES NOT OTHERWISE PROVIDED FOR
51Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
Appl.No 17075969 Applicant UNIVERSAL DISPLAY CORPORATION Inventor Tyler FLEETHAM

Provided are boron-containing compounds having a structure of Formula I

embedded image

wherein ring A, Z, X1-X3, RA, RB, R1, and R2 are defined herein.

5.20210128578CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
US 06.05.2021
Int.Class A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
Appl.No 17098678 Applicant Nocion Therapeutics, Inc. Inventor Bridget McCarthy Cole

The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof:

embedded image

The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

6.20210128619USES OF ANTI-BCMA CHIMERIC ANTIGEN RECEPTORS
US 06.05.2021
Int.Class A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Appl.No 17089594 Applicant CELGENE CORPORATION Inventor Timothy CAMPBELL

Provided herein are uses of anti-B cell maturation antigen (BCMA) chimeric antigen receptors (CARs) for treating B-cell related conditions, such as BCMA-expressing cancers.

7.102019217139Gasphasen-Beschichtungsverfahren mit einem mindestens zweifach funktionalisierten Organosilan als Präkursor
DE 06.05.2021
Int.Class C23C 16/30
CCHEMISTRY; METALLURGY
23COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
CCOATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
16Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition (CVD) processes
22characterised by the deposition of inorganic material, other than metallic material
30Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
Appl.No 102019217139 Applicant Robert Bosch GmbH Inventor Aichele Wilfried

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung einer Beschichtung (12) auf einem Substrat (11), in dem das Substrat (11) mittels einer chemischen Reaktion von mindestens einer Organosiliciumverbindung als Präkursor und eines Abscheideprozesses aus einer Gasphase mit der Beschichtung (12) beschichtet wird. Um eine, insbesondere auch dauerhaft, dichte und stabile Beschichtung mit sehr guten Haftungs- und/oder Anbindungseigenschaften für andere Materialien, wie Kunststoffe und/oder Klebstoffe, bereitzustellen, umfasst die Gasphase als Präkursor mindestens ein Organosilan mit mindestens zwei Substituenten, welche jeweils über eine Silicium-Kohlenstoff-Bindung an Silicium angebunden sind und jeweils mindestens eine funktionelle Gruppe umfassen. embedded image

8.WO/2021/083459PROCESS FOR THE SYNTHESIS OF DOPA COMPRISING A PHOTOLABILE PROTECTIVE GROUP, AND INTERMEDIATES FOR THE PREPARATION THEREOF
WO 06.05.2021
Int.Class C07C 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
1Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
Appl.No PCT/DE2020/100915 Applicant CHIRACON GMBH Inventor QUINT, Stephan
The invention relates to a process for the synthesis of DOPA comprising a photolabile protective group and to intermediates for preparing same (I), R being selected from the group that consists of 2-nitrobenzyl,1-(2-nitrophenyl)ethyl, 7-nitroindolin-1-yl, (7-ethoxycumarin-4-yl)methyl, {7-[bis(carboxymethyl)amino]-cumarin-4-yl}methyl, (6-bromo-7-hydro- xycumarin-4-yl)methyl, desoxybenzoinyl, p-hydroxyphenacyl, (8-bromo-7-hydroxyquinoline-2-yl)methyl, and [7-(diethylamino)cumarin-4-yl]methyl.
9.WO/2021/083879BROMODOMAIN INHIBITORS
WO 06.05.2021
Int.Class A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Appl.No PCT/EP2020/080156 Applicant RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN Inventor BOLM, Carsten
The invention relates to compounds according to the general formula (1), to their use for producing a medicament, in particular for the treatment of bromodomain-related diseases, such as cancers.
10.WO/2021/084044HYDROGEN CARRIER COMPOUNDS
WO 06.05.2021
Int.Class C01B 3/00
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
3Hydrogen; Gaseous mixtures containing hydrogen; Separation of hydrogen from mixtures containing it; Purification of hydrogen
Appl.No PCT/EP2020/080464 Applicant HYSILABS SAS Inventor BURCHER, Benjamin
The present invention relates to siloxane hydrogen carrier compounds and to a method for producing hydrogen from said siloxane hydrogen carrier compounds.