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1.20210128532HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
US 06.05.2021
Int.Class A61K 31/4192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41921,2,3-Triazoles
Appl.No 17081940 Applicant GyanRx Sciences, Inc. Inventor Julian A. Codelli

The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof.

2.20210128452COMPOSITIONS AND METHODS OF IMPROVING THE SKIN MICROBIOME
US 06.05.2021
Int.Class A61K 8/99
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
96containing materials, or derivatives thereof, of undetermined constitution
99from microorganisms other than algae or fungi, e.g. protozoa or bacteria
Appl.No 17089469 Applicant SEED HEALTH INC. Inventor Rajat Dhir

The present invention comprises compositions, systems, and methods of improving the skin and the skin microbiome using bacterial strains and their derivatives, and prebiotics. A useful composition of the invention comprises at least one of (a) a prebiotic that selectively promotes the growth of at least one desirable strain of Cutibacterium acnes (C. acnes); (b) a probiotic comprising at least one desirable strain of C. acnes; and (c) a post-biotic comprising at least one molecule produced by C. acnes.

3.20210128619USES OF ANTI-BCMA CHIMERIC ANTIGEN RECEPTORS
US 06.05.2021
Int.Class A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Appl.No 17089594 Applicant CELGENE CORPORATION Inventor Timothy CAMPBELL

Provided herein are uses of anti-B cell maturation antigen (BCMA) chimeric antigen receptors (CARs) for treating B-cell related conditions, such as BCMA-expressing cancers.

4.WO/2021/084494NOVEL PEPTIDES AND USES THEREOF FOR TREATING CANCER
WO 06.05.2021
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No PCT/IB2020/060207 Applicant SYMTHERA CANADA LTD. Inventor EZERZER, Chai
Presented herein are cancer peptide agents and uses thereof for treating cancer and/or inhibiting metastasis. Also presented herein are methods of treating cancer, or inhibiting metastasis of cancer in a subject, comprising administering a therapeutically effective amount of a composition comprising one or more cancer peptide agents to the subject. Also presented herein is a method of treating a cancer in a subject, or inhibiting metastasis of a cancer in a subject that comprises administering a therapeutically effective amount of a composition comprising one or more cancer peptide agents, and administering a chemotherapy or chemotherapeutic agent.
5.WO/2021/085769COMPOSITION COMPRISING BOTULINIUM TOXIN OR SALT THEREOF FOR INCREASING ENDOMETRIAL BLOOD FLOW RATE
WO 06.05.2021
Int.Class A61K 38/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
Appl.No PCT/KR2020/005626 Applicant CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION Inventor KANG, Youn Jung
The present invention relates to a composition comprising Botulinium toxin or a salt thereof for increasing an endometrial blood flow rate, a composition for improving an implantation potential, and a pharmaceutical composition comprising Botulinium toxin or a pharmaceutically acceptable salt thereof for prevention or treatment of substerility or infertility. Even when being just applied to the endometrium, the compositions can improve an embryonic implantation potential as well as inducing an increase of endometrial blood flow rate. Thus, the compositions are helpful for patients with substerility or infertility, especially patients who suffer from repeated failure in embryonic implantation. Furthermore, a period of study into human toxicity can be reduced because the compositions contain Botulinium toxin, which is a material that has been widely applied to the human body for beauty purposes. Thus, the present invention is very advantageous in terms of economic and industrial aspects.
6.WO/2021/083204KERATIN BD-14, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
WO 06.05.2021
Int.Class C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Appl.No PCT/CN2020/124365 Applicant INSTITUTE OF MATERIA MEDICA , CHINESE ACADEMY OF MEDICAL SCICENCES Inventor YU, Shishan
Provided are keratin BD-14, a nucleic acid molecule encoding keratin BD-14, an expression vector containing the nucleic acid molecule, a host cell containing the expression vector or a genome integrated with the nucleic acid molecule, a preparation method for keratin BD-14, a pharmaceutical composition containing keratin BD-14, and an application of said keratin BD-14, nucleic acid molecule, expression vector, host cell, or pharmaceutical composition in preparing antipyretic and analgesic, antitussive and expectorant, anticonvulsant, antiepileptic, blood pressure lowering, anti-inflammatory and antiviral drugs.
7.WO/2021/086219LIGHT-GATED PENTAMERIC CHANNEL - A NEW OPTOGENETIC TOOL
WO 06.05.2021
Int.Class C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Appl.No PCT/RU2019/000776 Applicant FORSCHUNGSZENTRUM JÜLICH, INSTITUTE OF COMPLEX SYSTEMS Inventor BRATANOV, Dmitry Olegovich
The invention relates to newly characterized light-gated pentameric channels such as OLPVRII and their use in medicine, their utility as optogenetic tools, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells expressing said light-gated pentameric channels and their respective uses.
8.WO/2021/086234NOVEL CHEMICAL COMPOUND L-LYSINE 9-OXOACRIDINYL-10-ACETATE
WO 06.05.2021
Int.Class C07D 219/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
219Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
04with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
06Oxygen atoms
Appl.No PCT/RU2020/050289 Applicant SCIENTIFIC TECHNOLOGICAL PHARMACEUTICAL FIRM "POLYSAN" LTD. Inventor KOVALENKO, Alexey Leonidovich
The invention relates to chemistry, pharmaceuticals and medicine, and specifically to a new chemical compound of the class of derivatives of 9-oxoacridinyl-10-acetate: L-lysine 9-oxoacridinyl-10-acetate, which stimulates production of interleukin-24 (IL-24) and tumor necrosis factor beta (TNF-β) and has anti-tumor activity. The invention may be used in anti-tumor therapy, in particular, as an adjuvant in the complex treatment of oncological diseases. The invention addresses the problem of creating a novel chemical compound which stimulates production of the cytokines interleukin-24 and tumor necrosis factor beta and exhibits anti-tumor activity with low toxicity. The stated problem is solved by a novel chemical compound: L-lysine 9-oxoacridinyl-10-acetate of formula (I) or (II).
9.WO/2021/086999THERAPEUTIC APPROACH FOR TREATING INFLAMMATORY BOWEL DISEASE
WO 06.05.2021
Int.Class A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Appl.No PCT/US2020/057784 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor GONZALEZ, David J.
Provided herein are compositions and methods to that target microbial proteases to ameliorate the intestinal barrier dysfunction and restore mucosal integrity. They are useful to treat and prevent diseases and disorders caused by pathogenic bacteria in the gastrointestinal system of a subject.
10.20210128683PHARMACEUTICAL COMPOSITIONS AND USE THEREOF FOR RELIEVING RESISTANCE DUE TO CANCER CHEMOTHERAPY AND ENHANCING EFFECT OF CANCER CHEMOTHERAPY
US 06.05.2021
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No 17144823 Applicant Rise Biopharmaceuticals Inc. Inventor Jya-Wei CHENG

The present invention provides a novel chemokine receptor antagonistic modified peptide. The novel chemokine receptor antagonistic modified peptide can be combined with a chemotherapeutic drug for treating cancer, especially for treating drug-resistant cancer, and inhibiting tumor growth more effectively.