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IC:G01N33/569

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Analysis

1 / 3,537
1.WO/2025/132472METHOD FOR DETECTING VIABLE MICROORGANISMS WHICH ARE POTENTIALLY PRESENT IN A SAMPLE OF CELLULAR PRODUCTS
WO - 26.06.2025
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
 Appl.No PCT/EP2024/086952 Applicant BIOMERIEUX Inventor DE LA FOATA, Corinne
The present invention relates to a method for isolating viable microorganisms which are potentially present in a sample comprising 106 to 108 immune cells or progenitor cells thereof, the method comprising the following steps: - bringing the sample into contact with: • a lysing composition comprising o a lysis buffer comprising a non-ionic detergent at a concentration of between 0.004% and 0.050% of the reaction volume o and/or a lysis solution comprising a saponin at a concentration of between 0.03% and 4% of the reaction volume; • an endonuclease for digesting the nucleic acids released by the action of the lysing composition; • an endopeptidase acting at a pH of between 7 and 8; - separating the viable microorganisms which are potentially present in the sample by filtering the sample through a filter, the pores of which have a diameter of between 0.30 and 0.50 μm. The present invention also relates to the associated solid-phase cytometry detection method.
2.20250208133SENESCENT CELL SURFACE MARKERS
US - 26.06.2025
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
 Appl.No 18835014 Applicant SENS RESEARCH FOUNDATION Inventor Amit SHARMA

Senescent cells are implicated in aspects of age-related decline in health and may contribute to certain diseases. Embodiments include biomarkers that are unique to senescent cells. The biomarkers have diagnostic and therapeutic uses for senescence-associated diseases and disorders. Embodiments also include methods of distinguishing non-senescent cells from senescent cells based on the presence or absence of one or more of the biomarkers. Senescent cells can be selectively labelled to detect an ailment in a subject, devise a treatment and/or determine the effectiveness of a senolytic agent. Embodiments also include methods of removing senescent cells from a patient or an affected tissue. The method can target senescent cells by inhibiting lysosomal exocytosis.

3.20250208136Peptides and combinations of peptides for use in immunotherapy against oropharyngeal squamous cell carcinoma (OPSCC) and other cancers
US - 26.06.2025
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
 Appl.No 19039730 Applicant Eberhard Karls Universität Tübingen Medizinische Fakultät Inventor Simon Laban

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular of oropharyngeal squamous cell carcinoma (OPSCC). The present invention furthermore relates to tumor-associated T-cell peptide epitopes that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

4.20250208134DEVICE AND METHOD FOR CHARACTERIZATION OF BIOLOGICAL CELLS
US - 26.06.2025
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
 Appl.No 18987869 Applicant IMEC VZW Inventor Willem VAN ROY

According to an aspect of the present inventive concept there is provided a device for characterizing biological cells comprising: a flow channel passing a flow of liquid carrying the biological cells to be characterized, the flow channel comprises at least one zone associated with a cell category; at least one detector to detect information representing the biological cells passing the at least one zone; a processor configured to receive and process the information by: dividing each zone into segments; identifying candidate biological cells; identifying tracks from each of the candidate biological cells; for each track, determining a set of transit times, wherein each transit time represents a transit time of the candidate biological cell through a segment; for each candidate biological cell, processing the set of transit times for characterizing the candidate biological cell by determining whether the candidate biological cell is a biological cell belonging to an associated biological cell category of each respective zone.

5.20250208132A DEVICE AND A METHOD FOR ANALYZING BIOLOGICAL CELLS
US - 26.06.2025
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
 Appl.No 18987770 Applicant IMEC VZW Inventor Tim STAKENBORG

According to an aspect of the present inventive concept there is provided a device for analyzing biological cells comprising: a flow channel passing a flow of liquid carrying the biological cells to be analyzed, the flow channel comprises at least one zone associated with a cell category; at least one detector to detect information representing the biological cells passing the at least one zone; a processor configured to receive and process the information by: identifying candidate biological cells; identifying tracks from the candidate biological cells; identifying candidate modified movements as events in each track; determining event related information associated with the event, the event related information comprises at least a sensed property of the candidate biological cells and/or a property defining a relation between events of at least two tracks from candidate biological cells; identifying candidate non-specific modified movements among the candidate modified movements; and removing the candidate non-specific modified movements from the candidate modified movements for each track.

6.20250206784MODIFIED SPIKE PROTEINS AND USES THEREOF
US - 26.06.2025
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No 18851843 Applicant CILOA Inventor Zaïne El Abiddine Robert MAMOUN

A nucleic acid coding for a modified Spike protein from a virus of the Orthocoronavirinae subfamily, an extracellular vesicle expressing a modified Spike protein from a virus of the Orthocoronavirinae subfamily, and a population of the extracellular vesicles. Also, the use of the nucleic acid, extracellular vesicle or population of extracellular vesicles for use in a method of immunizing a subject against a virus of the Orthocoronavirinae subfamily, in methods of production and screening of neutralizing antibodies.

7.WO/2025/134126METHOD OF RESOLVING DYNAMICS OF CELLULAR TRANSITIONS
WO - 26.06.2025
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
 Appl.No PCT/IL2024/051209 Applicant YEDA RESEARCH AND DEVELOPMENT CO. LTD. Inventor AMIT, Ido
A method of analyzing cell fate over a course of time is disclosed. The method comprises analyzing cells which have been temporally labelled at a predetermined location at at least two different time points using at least two different labels, each of said at least two different labels corresponding to one of said at least two different time points, wherein said cells temporally labelled at said at least two different time points have localized to a target location prior to said analyzing.
8.WO/2025/135582ANTI-SFTS VIRUS ANTIBODY AND USE THEREOF
WO - 26.06.2025
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
 Appl.No PCT/KR2024/019252 Applicant SCRIPPS KOREA ANTIBODY INSTITUTE Inventor SONG, Yong Bhum
The present invention relates to: an anti-SFTS virus antibody or an antigen-binding fragment thereof; a nucleic acid encoding same; a vector comprising the nucleic acid; a cell transformed with the vector; a method for preparing the antibody or the antigen-binding fragment thereof; a composition for preventing or treating SFTS virus infection, comprising same; and a composition for diagnosing same.
9.20250208135Biomarkers for Neurodegenerative Disease
US - 26.06.2025
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
 Appl.No 18557941 Applicant Yeda Research and Development Co. Ltd. Inventor Michal Eisenbach-Schwartz

The present invention provides a method for early detection or diagnosis of a neurodegenerative disease, disorder, or condition in a subject at risk of developing or suspected of having the neurodegenerative disease, disorder, or condition, the method comprising measuring in a blood sample obtained from the subject or a fraction thereof the levels of at least one biomarker selected from CD38+ peripheral blood mononuclear cells (PBMCs), trigonelline, GLUT1 expression in CD4+ T cells, Th2, Th2/Th1 ratio, naïve T cells, adenosine, allose, and HLA-DR T cells, as well as related methods and kits.

10.WO/2025/132598LECTIN-BASED ASSAY FOR DETECTING MICROBIAL CONTAMINATION
WO - 26.06.2025
Int.Class G01N 33/28
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
26Oils; Viscous liquids; Paints; Inks
28Oils
 Appl.No PCT/EP2024/087122 Applicant THE ANTIBODY LAB GMBH Inventor HIMMLER, Gottfried
An analytical method to detect microbial contaminants in an oily liquid, comprising: a) preparing an aqueous liquid from the oily liquid, thereby obtaining glycan-containing microbial material originating from any microbial contaminants comprised in the oily liquid; b) determining the presence of glycans in the aqueous liquid using a lectin-based lateral-flow assay (LFA) that employs a mannose-binding protein (MBP) as capture agent of a test region of a lateral flow membrane and as capture agent bound to flowable, identifiable reporter nanoparticles, using a capture reaction buffer (CRB) which comprises 100 to 500 mM free calcium ions, a detergent, a buffer agent and a pH ranging between 6.5 and 9.0, thereby allowing identification of a MBP sandwiched capture product at the test region, which indicates microbial contamination; and a test kit for use in the method, which comprises: a) a lectin-based lateral-flow assay (LFA) device, which employs mannose-binding protein (MBP) as capture agent that is bound to flowable, identifiable reporter nanoparticles at a reaction zone of a lateral flow membrane; and b) a running buffer which comprises a detergent, a buffer agent and a pH ranging between 6.5 and 9.0, and which sets an amount of 100 to 500 mM free calcium ions at the reaction zone.
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