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1.WO/2022/104465SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS DNA VACCINES
WO 27.05.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/CA2021/051633 Applicant UNIVERSITÉ LAVAL Inventor KOBINGER, Gary
DNA vaccine vectors composed of a vector portion and an antigen-coding portion that comprises a nucleic acid sequence encoding a severe acute respiratory syndrome coronavirus (SARS-CoV) antigen are provided. The DNA vaccines of the present disclosure are able to trigger an immune response towards SARS-CoV-2.
2.WO/2022/089233RECOMBINANT SPIKE PROTEIN, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
WO 05.05.2022
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/CN2021/124364 Applicant SHANGHAI ZERUN BIOTECHNOLOGY CO., LTD. Inventor AN, Jiao
Disclosed in the present invention are a recombinant spike protein, an encoding nucleic acid therefor, a preparation method therefor, a vaccine composition comprising the recombinant spike protein, and an application thereof. The recombinant spike protein can be used to prevent SARS-CoV-2 infection or a disease caused by SARS-CoV-2 infection.
3.WO/2022/087856ANTIGEN PRESENTING SYSTEM OF NOVEL CORONAVIRUS VACCINE USING ATTENUATED SALMONELLA FOR SECRETING AND EXPRESSING RBD DOMAIN PROTEIN, AND USE THEREOF
WO 05.05.2022
Int.Class C12N 15/74
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
Appl.No PCT/CN2020/124173 Applicant NANJING JIRUIKANG BIOTECHNOLOGY RESEARCH INSTITUTE CO., LTD. Inventor HUA, Zichun
An antigen presenting system of a novel coronavirus vaccine using attenuated salmonella for secreting and expressing an RBD domain protein, and the use thereof. The antigen presentation system is used for preventing novel coronavirus (SARS-CoV-2). By means of constructing a controllable and stable expression plasmid that secretes and expresses the RBD domain protein and engineering attenuated salmonella, an antigenic protein can be efficiently delivered to an antigen-presenting cell via an oral route and by means of the specific secretion system thereof after administration. The delivered antigenic protein can be effectively processed and presented by antigen-presenting cells, thereby ultimately realizing the activation/regulation of the immune system, producing antibodies, and exhibiting the function of a vaccine.
4.114425079一种核酸疫苗及其制备方法和应用
CN 03.05.2022
Int.Class A61K 39/385
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
Appl.No 202210083383.8 Applicant 深圳市儿童医院 Inventor 谢中建
本发明属于生物技术领域,具体涉及一种核酸疫苗及其制备方法和应用。本发明涉及的核酸疫苗包括核酸分子和DNA纳米结构,其中DNA纳米结构包括支架分子和互补链分子,其作为一种载体,与核酸分子通过碱基互补配对原则结合。这种核酸疫苗的制备方法为:将支架分子与互补链分子混合,折叠形成DNA纳米结构;将DNA纳米结构与核酸分子混合,杂交形成稳定的双链结构。这种核酸疫苗中的DNA纳米结构能够稳定核酸分子,保护核酸分子不被核酸酶攻击,提高核酸疫苗的储存、运输的便利性,解决核酸疫苗在广泛投入使用时存在的实际问题。因此,本发明所述的核酸疫苗可用于制备治疗新型冠状病毒肺炎的疫苗。
5.114410593一种以麻疹病毒为载体的重组新型冠状病毒疫苗的大规模生产工艺
CN 29.04.2022
Int.Class C12N 7/01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
Appl.No 202210197655.7 Applicant 成都生物制品研究所有限责任公司 Inventor 刘兰军
本发明提供了一种以麻疹病毒为载体的重组新型冠状病毒疫苗的大规模生产工艺,属于病毒载体疫苗制备领域。所述方法包括以下步骤:(1)细胞培养:在装载有细胞微载体的生物反应器内加入无血清细胞生长液,培养Vero细胞至密度为2~5×105cell/cm2;(2)病毒接种和培养:将重组病毒按0.001~0.1MOI接种到Vero细胞,用无血清病毒维持液培养7天,收获培养上清,得病毒收获液;(3)粗滤;(4)酶切;(5)超滤和洗滤(6)终滤。本发明的生产工艺安全、稳定、可控,批次间质量均一,利用该生产工艺制得的重组新型冠状病毒疫苗不仅效价高,而且Vero细胞DNA和Vero细胞宿主蛋白残留量低。本发明的生产工艺能够大规模生产高质量的重组新型冠状病毒疫苗,应用前景广阔。
6.114404584一种新型冠状病毒mRNA疫苗及其制备方法和用途
CN 29.04.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 202210336875.3 Applicant 康希诺生物股份公司 Inventor 王浩猛
本发明提供了新型冠状病毒mRNA疫苗及其制备方法和用途。本发明的新型冠状病毒mRNA疫苗可以诱导强烈的新型冠状病毒特异性的体液和/或T细胞免疫应答,并可以诱导产生可广泛中和多种变异毒株的中和抗体。本发明提供的新型冠状病毒mRNA疫苗递送载体具有良好的稳定性、递送效率高、安全有效质量可控。
7.WO/2022/086364AGENT FOR INDUCING SPECIFIC IMMUNITY AGAINST SARS-COV-2
WO 28.04.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/RU2021/000182 Applicant FEDERAL STATE BUDGETARY INSTITUTION "NATIONAL RESEARCH CENTRE FOR EPIDEMIOLOGY AND MICROBIOLOGY NAMED AFTER THE HONORARY ACADEMICIAN N.F. GAMALEYA" OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION Inventor ZUBKOVA, Olga Vadimovna
The invention relates to biotechnology, immunology and virology. There is described the agent for inducing specific immunity against SARS-CoV-2, in lyophilized (freeze-dried) form, which contains a single active component, comprising the expression vector of human adenovirus serotype 26, wherein the E1 and E3 regions are deleted and the ORF6-Ad26 region is replaced by ORF6-Ad5, with an integrated expression cassette selected from SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3. Also there is presented the variant of the agent for inducing specific immunity against SARS-CoV-2, in lyophilized (freeze-dried) form, which contains a single active component, comprising the expression vector of human adenovirus serotype 5, wherein the E1 and E3 regions are deleted, with an integrated expression cassette selected from SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 or of simian adenovirus serotype 25, wherein the E1 and E3 regions are deleted, with an integrated expression cassette selected from SEQ ID NO:4, SEQ ID NO:2, SEQ ID NO:3.
8.WO/2022/086365AGENT FOR INDUCING SPECIFIC IMMUNITY AGAINST SARS-COV-2
WO 28.04.2022
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No PCT/RU2021/000183 Applicant FEDERAL STATE BUDGETARY INSTITUTION "NATIONAL RESEARCH CENTRE FOR EPIDEMIOLOGY AND MICROBIOLOGY NAMED AFTER THE HONORARY ACADEMICIAN N.F. GAMALEYA" OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION Inventor ZUBKOVA, Olga Vadimovna
The invention relates to immunology. There is described the agent for inducing specific immunity against SARS-CoV-2, in liquid form, which contains a single active component, comprising the expression vector of human adenovirus serotype 26, wherein the E1 and E3 regions are deleted and the ORF6-Ad26 region is replaced by ORF6-Ad5, with an integrated expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3. In other variant the agent contains a single active component, comprising the expression vector of human adenovirus serotype 5, wherein the E1 and E3 regions are deleted, with an integrated expression cassette selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3. In one more variant, the agent contains a single active component, comprising the expression vector of simian adenovirus serotype 25, wherein the E1 and E3 regions are deleted, with an integrated expression cassette selected from SEQ ID NO: 4, SEQ ID NO: 2, SEQ ID NO: 3.
9.WO/2022/083760FUSION PROTEIN AND APPLICATION THEREOF
WO 28.04.2022
Int.Class C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Appl.No PCT/CN2021/125834 Applicant JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION (PUBLIC HEALTH RESEARCH INSTITUTE OF JIANGSU PROVINCE) Inventor ZHU, Fengcai
The present application relates to one or more fusion proteins, comprising a structural domain of SARS-CoV-2 S(Spike) protein. The present application also relates to an immunogenic composition comprising the fusion protein and an application thereof.
10.WO/2022/085530PRETREATMENT METHOD FOR PREPARING SAMPLE TO BE SUPPLIED FOR METHOD FOR DETECTING FOREIGN NUCLEIC ACID
WO 28.04.2022
Int.Class C12N 15/40
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
Appl.No PCT/JP2021/037851 Applicant TOYOBO CO., LTD. Inventor KAWASHIMA Yosuke
The purpose of the present invention is to provide a simple method for preparing a sample to be supplied for a method for detecting foreign nucleic acid. The present invention provides a pretreatment method for a sample to be supplied for a method for detecting foreign nucleic acid, the method comprising: (A) a step for preparing a mixture solution containing a sample and a serine protease; (B) a step for causing an enzymatic reaction by the serine protease in the mixture solution prepared in step (A); (C) a step for heating the mixture solution in which the enzymatic reaction has taken place in step (B); and (D) a step for mixing an alkaline solution and the mixture solution that has undergone the heating in step (C).