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Analysis

1.WO/2022/109371FILTRATION SYSTEMS,COMPONENTS AND METHODS
WO 27.05.2022
Int.Class B01D 61/14
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
14Ultrafiltration; Microfiltration
Appl.No PCT/US2021/060264 Applicant ABEC, INC. Inventor KLOPP, Chris
This disclosure generally relates to purification systems using tangential flow filtration ("TFF") ("TFF systems") that include at least one single-use, disposable flow path wherein the disposable flow path is comprised of a disposable cassette manifold, disposable tubing (including associated components) and a disposable reactor vessel.
2.WO/2022/107067CUVETTE FOR MACROSCALE 3D GROWTH AND TREATMENT OF CELLS
WO 27.05.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/IB2021/060753 Applicant REAL RESEARCH SP. Z O. O. Inventor KRZYKAWSKI, Marcin
The subject of the invention is a cuvette (3) for 3D cell culture growth comprising a main container (5) comprising a means for macroscale 3D growth of cells and two end covers (4) at inlet and outlet ends of the main container (5), connected with cell culture media input and output tubing, wherein fluid transportation ports (7) placed at the inlet and outlet end covers (4), wherein the cuvette is preferably transparent and filled with transparent hydrogel.
3.WO/2022/108117CEREBRAL ORGANOID-MOTOR NEURON SPHEROID STRUCTURE AND FABRICATION METHOD THEREFOR
WO 27.05.2022
Int.Class C12N 5/0793
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
079Neural cells
0793Neurons
Appl.No PCT/KR2021/014097 Applicant SOGANG UNIVERSITY RESEARCH & BUSINESS DEVELOPMENT FOUNDATION Inventor CHOI, Jeong-Woo
The present invention relates to a cerebral organoid-motor neuron spheroid structure and a fabrication method therefor. The structure can be fabricated by co-culturing a cerebral organoid and motor neuron spheroids in a co-culture chip which is designed to bring the cerebral organoid and the motor neuron spheroids into independent contact with a proper culture medium. The structure can be effectively used for screening drugs for prevention or treatment of brain diseases causative of motor disturbance or for a toxicity assay because electrical signal change of motor neurons according to specific substances stimulating the cerebrum can be observed from the structure.
4.WO/2022/107006METHODS AND DEVICES FOR RAPID DETECTION OF COVID-19 AND OTHER PATHOGENS
WO 27.05.2022
Int.Class C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
Appl.No PCT/IB2021/060631 Applicant KHALIFA UNIVERSITY OF SCIENCE AND TECHNOLOGY Inventor ALAZZAM, Anas
A device (10) and method for detecting COVID-19 and other pathogens includes a sample compartment (26) contained within an interior of the device and having multiple apertures (32) for releasably receiving one or more test tubes (42) containing a biological sample. A bottom portion (48) of the test tube (42) is contained within the interior (22) of the device (10) and a top portion (46) of the test tube (42) is exposed to atmosphere. The biological sample is lysed using the device (10); the lysed sample is mixed with one or more primers and then amplification (RT-LAMP) is performed using the device (10). A thermally conductive material on or in proximity to the sample compartment (26) can facilitate precise heating of the compartment (26) and sample. A thermally insulative material can be inside the interior of the compartment housing (30). Multiple samples can be tested simultaneously. The results can be interpreted by a color change of the sample. The device (10) is efficient, portable, reliable, and re-usable.
5.WO/2022/106480APPARATUS FOR BIO-PRODUCT PROCESSING
WO 27.05.2022
Int.Class B01D 15/22
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
22relating to the construction of the column
Appl.No PCT/EP2021/082008 Applicant CYTIVA SWEDEN AB Inventor ERIKSSON, Stefan, K
The present invention relates to an apparatus (200) for bio-product processing. The apparatus (200) comprise a processing column (201) comprising an upper column tube (202B) releasably coupled to a lower column tube (202A). The lower column tube (202A) has a processing chamber (218) provided therein. The apparatus (200) additionally comprises an adapter (222) for moving within the processing column (201) so as to vary the volume of the processing chamber (218) within the lower column tube (202A), and a column stand (214) for supporting the adapter (222).
6.WO/2022/108968OPEN-WELL MICROCAVITY PLATE
WO 27.05.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/US2021/059622 Applicant CORNING INCORPORATED Inventor LACEY, William, Joseph
Cell culture devices comprise a frame comprising an open well disposed therein and a fluid inlet area in communication with the open well. The open well comprises a top opening, a bottom plate comprising a microcavity substrate, the bottom plate defining a major surface, and one or more sidewalls extending from the bottom plate to the top opening. The microcavity substrate comprises a plurality of microcavities, and each microcavity is configured such that cells cultured in the well form a spheroid. The cell culture device may be a reservoir open well microcavity plate used for spheroid cell culture.
7.WO/2022/108815SALIVA SPECIMEN CONTAINER
WO 27.05.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/US2021/058916 Applicant PLASTEK INDUSTRIES, INC. Inventor PISCOPO, Peter A.
A specimen collection container or container kit (20) has: a container body (22) having a rim (46); an inlet valve body (28) mounted to the container body; an inlet valve element (30) mounted to the inlet valve body and depressable from a closed condition to an open condition; and a funnel (24) mounted to or mountable to the inlet valve body and depressable to drive the inlet valve element from the open condition to the closed condition.
8.WO/2022/109113METHODS AND SYSTEMS FOR MECHANOPORATION-BASED PAYLOAD DELIVERY INTO BIOLOGICAL CELLS
WO 27.05.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/US2021/059856 Applicant CELLFE, INC. Inventor HAN, Sewoon
Described herein are methods and systems for mechanoporation-based high-throughput payload delivery into biological cells. For example, one system can process at least 1 billion cells per minute or at least 25 billion cells per minute, which is substantially greater than conventional methods. A cell processing apparatus comprises a processing assembly formed by stacking multiple processing components. Each processing component comprises channels, which may be used for filtration, mechanoporation, and/or separation of cells in the cell media. This functionality depends on the configuration of each channel. For example, each channel comprises one or more ridges such that each ridge forms a processing gap with an adjacent one of the processing components. The ridges may extend to the side walls or form a bypass gap with the wall. The processing gaps can be specially configured to compress cells as the cells pass through these gaps thereby initiating the mechanoporation process.
9.WO/2022/106202DEVICE FOR TREATING CELLS IN A BYPASS
WO 27.05.2022
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
Appl.No PCT/EP2021/080498 Applicant BÜHLER AG Inventor BUCHMANN, Leandro
The present invention is related to a device (1), comprising a unit (2) for taking up a fluid, a unit (3) for emitting electric pulses, wherein said unit (2) for taking up a fluid and said unit (3) for emitting electric pulses are connected with each other via lines (4a, 4a', 4b, 4b') so as to form a circuit, wherein there are provided connections (5a, 5b) for connecting the lines (4a, 4b) arranged at said unit (2) for taking up a fluid with the lines (4a', 4b') arranged at said unit (3) for emitting electric pulses in a releasable, hygienic and leakage-free manner. The present invention is related to an apparatus (9) comprising said device (1), and to a method for treating cells performed with said device (1) or said apparatus (9).
10.WO/2022/108436SYSTEM FOR REAL-TIME AUTOMATIC QUANTITATIVE EVALUATION, EVALUATION AND/OR RANKING OF INDIVIDUAL SPERM, INTENDED FOR INTRACYTOPLASMIC SPERM INJECTION (ICSI) AND OTHER FERTILIZATION PROCEDURES, WHICH ALLOWS THE SELECTION OF A SINGLE SPERM
WO 27.05.2022
Int.Class G01N 15/10
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
Appl.No PCT/MX2021/050076 Applicant CHAVEZ BADIOLA, Alejandro Inventor CHAVEZ BADIOLA, Alejandro
The present invention advantageously remedies the previously mentioned shortcomings by providing a system based on artificial vision and artificial intelligence, which is capable of assisting an embryologist to select the best spermatozoa for injection during an ICSI procedure and other fertilisation procedures requiring the selection of a single sperm. The system of the invention is capable of identifying the best spermatozoa in a sample, in real time, on the basis of their morphological and motility characteristics observed under a microscope with magnification greater than or equal to 20x. The invented system automatically analyses sequences of images produced by a digital camera connected to a microscope, in real time. The system uses computer-based vision algorithms to automatically detect and trace each spermatozoon in each image of a video and calculate a series of characteristics related to morphological characteristics and motility parameters. The characteristics of each sperm are processed and then evaluated using a mathematical model that determines the quality of each sperm and consequently rates them. The rating result is shown to the user in real time, together with a visual indication of which spermatozoa have the best quality in the sample from the image.