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IC:C07K16/10

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Analysis

1.WO/2022/107737SARS-CoV-2 DETECTION KIT AND SARS-CoV-2 DETECTION METHOD
WO 27.05.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/JP2021/041983 Applicant FUJIFILM CORPORATION Inventor UJIHARA Dai
The present invention addresses the problem of providing a SARS-CoV-2 detection kit and a SARS-CoV-2 detection method that enable the detection of SARS-CoV-2 in a simple manner and with higher sensitivity. The present invention provides a SARS-CoV-2 detection kit for specifically detecting a nucleocapsid protein (NP) contained in a biological sample, the SARS-CoV-2 detection kit comprising at least one antibody that specifically reacts with a SARS-CoV-2 nucleocapsid protein (NP), wherein the antibody includes at least one antibody of which the subclass is IgG2b, and the kit includes a first container that receives a silver-containing compound, and a second container that receives a reducing agent that can reduce silver ions.
2.WO/2022/105772BISPECIFIC ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST CORONAVIRUS, AND USE THEREOF
WO 27.05.2022
Int.Class C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Appl.No PCT/CN2021/131080 Applicant SANYOU BIOPHARMACEUTICALS CO., LTD. Inventor LANG, Guojun
Provided are a bispecific antibody having a neutralizing activity against a coronavirus, and a use thereof. A neutralizing antibody which is against a coronavirus S protein and blocks the binding of the coronavirus S proteins to an ACE 2 receptor is provided to prevent and treat coronaviruses. Specifically provided is an antibody or polypeptide complex specifically binding to a coronavirus S protein, comprising: (a) a first epitope binding moiety comprising a heavy chain variable region VH and a light chain variable region VL, wherein the VH and VL form an antigen binding domain specifically binding to a first epitope of an S protein; and (b) a second epitope binding moiety comprising a single-domain antibody or a VHH fragment thereof specifically binding to a second epitope of the S protein, wherein the first and second epitope binding portions are fused to each other and are not identical to each other. Also provided is a polynucleotide for encoding an antibody or a polypeptide complex and a host cell comprising same, and a method for preparing an antibody or a polypeptide complex. The antibody or polypeptide complex can be used for preventing, treating, diagnosing, and/or detecting coronaviruses.
3.WO/2022/109317ANTI-INFLUENZA ANTIBODIES AND COMBINATIONS THEREOF
WO 27.05.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/US2021/060166 Applicant VIR BIOTECHNOLOGY, INC. Inventor CORTI, Davide
The present disclosure relates, in part, to anti-influenza antibodies (and antigenbinding fragments thereof) and combinations thereof for preventing and treating influenza infection. Presently disclosed combinations provide surprising synergistic effects and can potently prevent, inhibit, or neutralize an influenza infection, such as an influenza A virus (IAV) infection an influenza B virus (IBV) infection, or both.
4.WO/2022/104918BISPECIFIC ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST CORONAVIRUS, AND USE THEREOF
WO 27.05.2022
Int.Class C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Appl.No PCT/CN2020/133194 Applicant SANYOU BIOPHARMACEUTICALS CO., LTD. Inventor LANG, Guojun
A bispecific antibody having neutralizing activity against coronavirus and the use thereof. Provided is a neutralizing antibody against a coronavirus S protein and for blocking same from binding to an ACE2 receptor to prevent and treat coronavirus. Specifically, the present invention relates to an antibody or a polypeptide complex that specifically binds to the coronavirus S protein, which antibody or polypeptide complex comprises: (a) a first epitope binding moiety, which comprises a heavy chain variable region VH and a light chain variable region VL, wherein VH and VL form an antigen binding domain of a first epitope that specifically binds to the S protein; and (b) a second epitope binding moiety, which comprises a single-domain antibody of a second epitope that specifically binds to the S protein, or a VHH fragment thereof, wherein the first and second epitope binding moieties are fused to each other and are different from each other. The present invention also relates to a polynucleotide encoding the antibody or polypeptide complex, a host cell comprising same, and a method for preparing the antibody or polypeptide complex. The antibody or polypeptide complex can be used to prevent, treat, diagnose and/or detect coronavirus.
5.WO/2022/106205CORONA VIRUS SPIKE PROTEIN BINDING COMPOUNDS
WO 27.05.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/EP2021/080560 Applicant RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN Inventor WU, Nicholas
The invention pertains to protein binding compounds, such as antibodies and antibody like compounds, specifically targeting epitopes of the Corona virus spike (S) protein which were found to stabilize a three-dimensional conformation of the protein which reduces or inhibits the viral mechanisms necessary for host cell entry. The invention provides the protein binding compounds alone and in combination and multispecific constructs, as well as their use in the prevention, treatment, patient stratification and diagnosis of viral infections caused by a corona virus such as severe acute respiratory syndrome corona virus 2 (SARS CoV2).
6.WO/2022/109309BROADLY NEUTRALIZING ANTIBODIES AGAINST INFLUENZA NEURAMINIDASE
WO 27.05.2022
Int.Class A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
Appl.No PCT/US2021/060155 Applicant VIR BIOTECHNOLOGY, INC. Inventor CORTI, Davide
The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to an influenza virus neuraminidase (NA) and can neutralize an influenza virus infection. Also provided are polynucleotides that encode an antibody, vectors that comprise such polynucleotides, host cells that can express the antibodies, related compositions, and methods of using the herein disclosed compositions to, for example, treat or prevent an influenza infection.
7.WO/2022/109068INFLUENZA VIRUS ENCODING A TRUNCATED NS1 PROTEIN AND A SARS-COV RECEPTOR BINDING DOMAIN
WO 27.05.2022
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/US2021/059788 Applicant VIVALDI BIOSCIENCES INC. Inventor ASPELUND, Amy
The present invention refers to a recombinant influenza virus encoding a fusion protein comprising a truncated NS1 protein and a SARS-CoV receptor binding domain, specifically a SARS-CoV-2 RBD, and its use for prophylactic treatment, a pharmaceutical preparation comprising said virus for use in prime boost vaccination and a two-component vaccine for prime boost vaccination.
8.WO/2022/109443SINGLE-CHAIN ANTIBODY AGAINST FLAVIVIRUS NS1 PROTEIN
WO 27.05.2022
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/US2021/060468 Applicant THE REGENTS OF THE UNIVERSITY OF MICHIGAN Inventor SMITH, Janet L.
The disclosure is directed to binding agents, e.g., a single chain variable fragment (scFv) that specifically binds to a flavivirus NS1 protein, as well as compositions comprising the binding agent and a method of using such compositions to induce an immune response against a flavivirus (e.g., a dengue virus). The disclosure also provides a conjugate comprising the binding agent, and a recombinant NS1 antigen.
9.WO/2022/106726IgY ANTIBODIES FOR THE PREVENTION AND TREATMENT OF CORONA VIRUS CAUSED DISEASES
WO 27.05.2022
Int.Class C07K 16/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
02from eggs
Appl.No PCT/EP2021/082700 Applicant NORIMUN AS Inventor EVENSEN, Lasse
The invention relates to antibody compositions, in particular an IgY antibody composition (for example as obtained by immunization of an egg-laying poultry), wherein the compositions comprise antibodies with binding specificity against one or more (such as two, three or four) antigens selected from Angiotensin Converting Enzyme 2 (ACE-2) antigen, Neuropilin 1 (NRP-1) antigen, SARS-CoV-2 Spike 1 Receptor Binding Domain (RBD) antigen, and SARS-CoV-2 Spike Glycoprotein 1 (S1) antigen. The invention further relates to such compositions for use in prevention and/or treatment of an infection of a coronavirus in an animal. The invention further relates to a pharmaceutical composition comprising such a composition. The invention further relates to an egg yolk from an egg from an egg-laying poultry (layer) and/or an IgY composition obtained therefrom, for use in prevention and/or treatment of an infection of a coronavirus in an animal, wherein the egg yolk comprises such IgY antibodies. The invention further relates to a method of in vitro diagnosis, wherein such an IgY antibody composition is contacted with a biological sample from an animal.
10.WO/2022/109291ANTIBODIES AGAINST INFLUENZA A VIRUSES
WO 27.05.2022
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
Appl.No PCT/US2021/060123 Applicant VIR BIOTECHNOLOGY, INC. Inventor CORTI, Davide
The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to an influenza A virus hemagglutinin (HA) and can neutralize a IAV infection. Also provided are polynucleotides that encode an antibody or antigen-binding fragment, vectors that comprise such polynucleotides, host cells that can express the antibodies or antigen-binding fragments, related compositions, and methods of using the herein disclosed compositions to, for example, treat or prevent an IAV infection.