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Analysis

1 / 172,985
1.WO/2024/094027BLOCKING SEQUENCE, KIT THEREOF, AND METHOD FOR USING SAME
WO - 10.05.2024
Int.Class A61K 47/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
 Appl.No PCT/CN2023/128795 Applicant SHENZHEN HONGSHENG BIOTECHNOLOGIES CO., LTD. Inventor TANG, Jie
The present invention relates to a composition for enhancing the delivery of an active agent or a therapeutic agent, such as a therapeutic nucleic acid. The composition comprises: (A) the active agent or the therapeutic agent, wherein preferably, the active agent or the therapeutic agent comprises a nucleic acid; (B) an amphiphilic block copolymer; (C) a cationic lipid; and (D) a non-cationic lipid. The present invention further provides a method for preparing, delivering and using the composition, and use of the composition for treating and/or preventing related diseases or conditions.
2.WO/2024/093907LIGAND FOR DELIVERING SIRNA TO EYE AND CENTRAL NERVOUS SYSTEM
WO - 10.05.2024
Int.Class C07D 265/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
281,4-Oxazines; Hydrogenated 1,4-oxazines
30not condensed with other rings
 Appl.No PCT/CN2023/127728 Applicant SHANGHAI RONA THERAPEUTICS CO., LTD. Inventor HUANG, Jinyu
Provided are a compound of formula (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The compound of formula (I) is contained inside a nucleotide, or at a 5' end and/or a 3' end, and is used for improving the ability of a double-stranded RNA to pass through the blood-brain barrier. The present invention further relates to a test kit, a pharmaceutical composition, a cell, a carrier, a double-stranded RNA, or an oligonucleotide comprising the compound of formula (I).
3.WO/2024/096022ANTI-ADIPONECTIN RECEPTOR ANTIBODY AND UTILIZATION OF SAME
WO - 10.05.2024
Int.Class C12N 15/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
 Appl.No PCT/JP2023/039323 Applicant MITSUBISHI TANABE PHARMA CORPORATION Inventor ASAHARA, Naomi
Provided is an anti-adiponectin antibody or an antibody fragment thereof in which LCDR1 includes an amino acid sequence of SEQ ID NO: 17 or 18, LCDR2 includes an amino acid sequence of SEQ ID NO: 19 or 20, LCDR3 includes an amino acid sequence of SEQ ID NO: 21, HCDR1 includes an amino acid sequence of SEQ ID NO: 22, HCDR2 includes an amino acid sequence of SEQ ID NO: 23, and HCDR3 includes an amino acid sequence of SEQ ID NO: 24.
4.WO/2024/095947WATER-IN-OIL EMULSION COSMETIC COMPOSITION
WO - 10.05.2024
Int.Class A61Q 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
 Appl.No PCT/JP2023/039037 Applicant MANDOM CORPORATION Inventor FUJITA, Noriko
Provided is a water-in-oil emulsion cosmetic composition that, compared to oil-based cosmetic compositions having the same properties, can realize better spread.　The water-in-oil emulsion cosmetic composition according to the present invention comprises: an oily component selected from the group consisting of animal/vegetable oils and hydrocarbon oils, having a melting point of 65-100°C, and being solid at 25°C (component A); an oily component selected from the group consisting of vegetable oils and fatty acid triglycerides, and being liquid at 25°C (component B); a non-ionic surfactant having a linear saturated alkyl chain with at least 13 carbons and having an HLB value of 2.8-8.0 (component C); and water (component D), where the content of component D is 15.0-50.0 mass%.
5.WO/2024/095962USE OF PYRIDINE DERIVATIVE WHICH IS TRPV1 ANTAGONIST
WO - 10.05.2024
Int.Class A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
 Appl.No PCT/JP2023/039098 Applicant SHIONOGI & CO., LTD. Inventor YAMAKAWA, Hidekuni
The present invention provides a novel pharmaceutical composition and a method for treating and/or preventing social impairment, such as autism spectrum disorder, fragile X syndrome, and/or autism spectrum-like symptoms. Specifically, provided is a pharmaceutical composition for the treatment and/or prevention of social impairment, the pharmaceutical composition comprising a compound represented by formula (I) (in the formula, R1 is a substituted or unsubstituted alkyl; R2 is a hydrogen atom or the like; A is N or the like; the dashed line represents the presence or absence of a bond; R3 is a substituted or unsubstituted alkyl or the like; m is 0 or 1; and R4 and R5 each independently represent a hydrogen atom or the like) or a pharmaceutically acceptable complex thereof.
6.WO/2024/095992IMPROVEMENT OF RENAL HYPOFUNCTION BY SUBSTANCE HAVING AMMONIA EXCRETION-PROMOTING EFFECT
WO - 10.05.2024
Int.Class A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
 Appl.No PCT/JP2023/039194 Applicant TAZ INC. Inventor KAMIMOTO TAKAHASHI Shoko
The present invention addresses the problem of providing a novel means for suppressing renal hypofunction, the means being capable of fundamentally improving diseases associated with renal hypofunction, including chronic kidney disease (CKD).　The present inventors solved the aforesaid problem by providing a novel means for suppressing renal hypofunction, the means suppressing and/or improving renal hypofunction in a living body using a substance having ammonia excretion-promoting effect. More specifically, the present invention solved the aforesaid problem by providing a renal hypofunction suppressing agent that contains a substance having ammonia excretion-promoting effect in a living body.
7.WO/2024/096577COMPOUND COMPRISING FC-BINDING UNIT, AND CONJUGATE PREPARED USING SAME
WO - 10.05.2024
Int.Class A61K 47/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
 Appl.No PCT/KR2023/017274 Applicant ABTIS CO., LTD. Inventor CHUNG, Sang Jeon
Some aspects of the present application provide a compound comprising an Fc-binding unit. The compound comprising an Fc-binding unit, of the present application, can be used for site-specific delivery of a group of interest to an antibody. In addition, some aspects of the present application provide a method for preparing an antibody conjugate, comprising a group of interest (for example, a reactive group), by using a compound comprising an Fc-binding unit.
8.WO/2024/096067CYCLIC PEPTIDE DERIVATIVE COMPOSITION FOR TREATING OR PREVENTING NEUROPATHIC PAIN AND/OR INFLAMMATORY PAIN
WO - 10.05.2024
Int.Class A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
 Appl.No PCT/JP2023/039447 Applicant DKS CO. LTD. Inventor MATSUMOTO, Kohei
Provided is a cyclic peptide derivative composition for treating or preventing neuropathic pain and/or inflammatory pain.　The present disclosure pertains to a composition containing: a compound for treating or preventing neuropathic pain and/or inflammatory pain; or a pharmaceutically acceptable salt, solvate, or prodrug thereof. Moreover, the present disclosure pertains to a method for treating or preventing neuropathic pain and/or inflammatory pain, the method comprising administering the composition containing the compound or the pharmaceutically acceptable salt thereof. The technique provided by the present disclosure can be used for: a cyclic peptide derivative for regulating the activity of neural cells; and a production method for the same.
9.WO/2024/096592CHIMERIC ANTIGEN RECEPTOR WITH INCREASED AFFINITY FOR METHOTHELIN AND USE THEREOF
WO - 10.05.2024
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
 Appl.No PCT/KR2023/017306 Applicant CELLENGENE INC Inventor AN, Jae Hyung
The present invention relates to an anti-mesothelin chimeric antigen receptor that specifically binds to mesothelin with increased affinity for methothelin. The anti-mesothelin chimeric antigen receptor according to an aspect exhibits specific binding ability to mesothelin with increased affinity for mesothelin and thus can be effectively used in the prevention or treatment of mesothelin-overexpressing cancer.
10.WO/2024/092407PIPERACILLIN AND TAZOBACTAM SPRAY-DRIED POWDER
WO - 10.05.2024
Int.Class A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
 Appl.No PCT/CN2022/128625 Applicant CURACO BIOPHARM (NANJING) CO., LTD. Inventor SIM, Kim Eng
Piperacillin and tazobactam spray-dried powder, which is powdered spherical particles prepared by means of a spray drying method, and comprises piperacillin or a pharmaceutically acceptable salt thereof and tazobactam or a pharmaceutically acceptable salt thereof, and further comprises one or more stabilizers selected from carbohydrates, amino acids and polyols. A piperacillin and tazobactam formulation prepared by means of a spray drying method.
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