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Analysis

1 / 469
1.WO/2025/140539ULTRAPOTENT BROARDLY NEUTRALIZING ANTIBODIES AGAINST SARS-COV-2 VARIANTS AND METHODS OF USE THEREOF
WO - 03.07.2025
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
 Appl.No PCT/CN2024/143146 Applicant THE UNIVERSITY OF HONG KONG Inventor CHEN, Zhiwei
Provided is in the field of immunology. Provided are broadly neutralizing antibodies against SARS-COV-2 variants, compositions and methods of prevention and treatment of SARS-COV-2 infection or transmission.
2.WO/2025/137632ANTIBODIES AGAINST HENIPAVIRUSES
WO - 26.06.2025
Int.Class C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
 Appl.No PCT/US2024/061561 Applicant MAPP BIOPHARMACEUTICAL, INC. Inventor WEST, Brandyn
Provided herein are Henipavirus antibodies. These Henipavirus antibodies bind to the Henipavirus F glycoprotein and have neutralizing activity against different Henipavirus species and strains. These antibodies are used in methods of inducing an immune response and methods of inhibiting Henipavirus infection. Additionally provided are methods of treating an infectious disease using such antibodies.
3.3216051GLUTAMIC ACID-BASED LIPIDS, LIPID NANOPARTICLE CONTAINING GLUTAMIC ACID-BASED LIPIDS, AND FORMULATIONS THEREOF
CA - 18.06.2025
Int.Class A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid , beta-alanine, epsilon-aminocaproic acid or pantothenic acid
198Alpha-amino acids, e.g. alanine or edetic acid
 Appl.No 3216051 Applicant PROVIDENCE THERAPEUTICS HOLDINGS INC. Inventor GOPALAKRISHNA PANICKER, RAJESH KRISHNAN
4.120154603氟苯达唑在制备抗黄病毒属病毒感染的药物中的应用
CN - 17.06.2025
Int.Class A61K 31/4184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
 Appl.No 202510341319.9 Applicant 华南农业大学 Inventor 亓文宝
本发明公开了氟苯达唑在制备抗黄病毒属病毒感染的药物中的应用。本发明利用氟苯达唑对建立的寨卡病毒细胞间传播模型进行处理发现，氟苯达唑能够抑制寨卡病毒的细胞间传播。在此基础上，本发明通过将氟苯达唑与靶向寨卡病毒E蛋白的中和抗体MZ54联用发现，二者联用可以显著提升对寨卡病毒传播的抑制效果。由此，可将氟苯达唑用于制备抗黄病毒属病毒感染的药物，还可将氟苯达唑与靶向黄病毒属病毒的中和抗体联用，实现抗病毒感染的效果。本发明有利于抑制寨卡病毒的传播，有利于黄病毒属病毒感染引起的病毒性疾病的防治，对维护公关卫生安全有重要意义。
5.120158462编码水痘-带状疱疹病毒糖蛋白E的mRNA疫苗
CN - 17.06.2025
Int.Class C12N 15/38
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
34Proteins from DNA viruses
38Herpetoviridae, e.g. herpes simplex virus, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, pseudorabies virus
 Appl.No 202311731062.5 Applicant 中生复诺健生物科技（上海）有限公司 Inventor 张云涛
本申请提供了一种编码水痘‑带状疱疹(VZV)糖蛋白E(gE)或其变异体的RNA，所述RNA包含与SEQ ID NO:11‑18中任一项所示的核苷酸序列具有至少80％、至少85％、至少90％、至少95％、至少96％、至少97％、至少98％或至少99％同一性的核苷酸序列。本申请提供的八种mRNA能在细胞内翻译，产生的VZV gE蛋白表达水平高，该mRNA经由脂质体纳米颗粒包封后形成的制剂通过肌肉注射到小鼠体内的方式，可诱导小鼠产生高滴度的gE特异性IgG抗体。
6.120137015抗猴痘病毒A35R蛋白的单克隆抗体或其抗原结合片段和应用
CN - 13.06.2025
Int.Class C07K 16/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
 Appl.No 202510314222.9 Applicant 中国科学院微生物研究所 Inventor 高福
本申请公开了抗猴痘病毒A35R蛋白的单克隆抗体或其抗原结合片段和应用。通过筛选全人抗体人源化小鼠抗A35R特异结合的记忆B细胞，获得的高保护效果的猴痘病毒抗体A35R‑10G7，其具有与猴痘病毒结合能力强、亲和力强、体内保护作用。
7.120137014抗猴痘病毒A35R蛋白的抗体及其制备方法和应用
CN - 13.06.2025
Int.Class C07K 16/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
 Appl.No 202510313338.0 Applicant 中国科学院微生物研究所 Inventor 高福
本申请公开了抗猴痘病毒的抗体及其制备方法和应用。本申请具体公开了八种对猴痘病毒A35R蛋白具有很好的亲和力的抗体(A35R‑9E4、A35R‑9F8、A35R‑10C4、A35R‑10D5、A35R‑10E7、A35R‑10H6、A35R‑18E2和A35R‑18H2)，且其具有很好的中和活性和一定的体内保护效果。
8.120137011抗猴痘病毒M1R蛋白的单克隆抗体及其应用
CN - 13.06.2025
Int.Class C07K 16/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
 Appl.No 202510309600.4 Applicant 中国科学院微生物研究所 Inventor 高福
本申请公开了抗猴痘病毒M1R蛋白的单克隆抗体及其应用。本申请具体公开了多种对M1R蛋白具有很好的特异性和亲和力的抗体(M1R‑12E10、M1R‑12H5、M1R‑12H6、M1R‑24A7、M1R‑24H1)，且其具有很好的中和活性和一定的体内保护效果。
9.120137013针对猴痘病毒B6R蛋白的人源化单克隆抗体及其应用
CN - 13.06.2025
Int.Class C07K 16/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
 Appl.No 202510312100.6 Applicant 中国科学院微生物研究所 Inventor 高福
本申请涉及针对猴痘病毒的人源化单克隆抗体及其应用，通过筛选全人抗体人源化小鼠抗B6R特异结合的记忆B细胞，获得的人源高中和活性的猴痘病毒抗体B6R‑16A1、B6R‑21G7、B6R‑22D12、B6R‑22F9和B6R‑22H1，具有与猴痘病毒结合能力强、体外中和性好、亲和力大、具有体内保护作用的特点。
10.120137010特异性结合HPV的抗体
CN - 13.06.2025
Int.Class C07K 16/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
 Appl.No 202411281225.9 Applicant 南京诺唯赞生物科技股份有限公司 Inventor 徐灵杰
本发明提供一组特异性结合HPV的抗体或其抗原结合片段。本发明还提供编码所述抗体或其抗原结合片段的多核苷酸、包含所述多核苷酸的载体、包含所述载体的宿主细胞、生成所述抗体的方法以及包含所述抗体的组合物。
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