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Analysis

1.20240247455EMITTER ARRAY FOR A LUNAR ROVER
US 25.07.2024
Int.Class E02D 3/11
EFIXED CONSTRUCTIONS
02HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL-SHIFTING
DFOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
3Improving or preserving soil or rock, e.g. preserving permafrost soil
11by thermal, electrical or electro-chemical means
Appl.No 18100679 Applicant GM Global Technology Operations LLC Inventor Satendra S. GURU

A lunar rover includes a lunar rover body, at least one wheel coupled with the lunar rover body, a drive module coupled with the at least one wheel, the drive module configured to drive rotation of the at least one wheel over a surface, an extension arm coupled to the lunar rover body, an emitter array coupled to the extension arm, and a controller electrically connected with the emitter array. The controller is configured to control the emitter array to emit at least one of laser electromagnetic waves or maser electromagnetic waves towards the surface to sinter lunar regolith particles on the surface.

2.20240247843COOLING LOOP WITH A SUPERCRITICAL FLUID SYSTEM USING COMPRESSED REFRIGERANT FLUID FLOW WITH A POSITIVE JOULE THOMSON COEFFICIENT
US 25.07.2024
Int.Class F25B 25/00
FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION OR SOLIDIFICATION OF GASES
BREFRIGERATION MACHINES, PLANTS, OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
25Machines, plant, or systems, using a combination of modes of operation covered by two or more of the groups F25B1/-F25B23/160
Appl.No 18586850 Applicant Supercritical Fluid Technologies, Inc. Inventor Kenneth Joseph James

Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

3.20240248073METHOD AND EQUIPMENT FOR DETERMINING AN ESTIMATED LIFE AND REMAINING USEFUL LIFE OF A MECHANICAL DEVICE
US 25.07.2024
Int.Class G01N 33/28
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
26Oils; Viscous liquids; Paints; Inks
28Oils
Appl.No 18409888 Applicant Aktiebolaget SKF Inventor Weiqi GUO

A method for determining an estimated life of a mechanical device includes (1) acquiring a load spectrum of the mechanical device within a predetermined time range; (2) acquiring a lubricant state of the mechanical device within the predetermined time range; (3) determining a plurality of operating states experienced by the mechanical device within the predetermined time range based on the acquired load spectrum and the acquired lubricant state, and (4) determining an estimated life of the mechanical device based on the plurality of operating states of the mechanical device within the predetermined time range. Each operating state corresponds to a particular range of load values in the load spectrum and a particular degree of contamination in the lubricant state. The method may also determine the remaining useful life of a mechanical device. The method may be implemented in a device for determining the estimated life of a mechanical device.

4.20240248075DEVICE WITH MULTIPLE TEST UNITS
US 25.07.2024
Int.Class G01N 33/487
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
483Physical analysis of biological material
487of liquid biological material
Appl.No 18441433 Applicant Zhejiang Orient Gene Biotech Co.,Ltd Inventor Lili SHEN

A device for detecting analytes in a sample includes a main body. The main body includes a plurality of testing units. Each testing unit is configured to detect one or more analytes in the sample. Each testing unit is separable from the main body, or/and the testing units are connected together through the main body. When testing needs to be performed, the testing units are separable from each other, or the testing units are separable from the main body. The testing units are inseparable from the main body after completing the testing and entering the main body again.

5.20240248083SALIVA PAIRED IMAGING TEST APPARATUS AND METHOD
US 25.07.2024
Int.Class G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Appl.No 18422976 Applicant Oral Genome Corp. Inventor Tina Saw

An apparatus and method for remote saliva testing in a variety of environments. The test involves the healthcare provider and the patient. Included is a non-invasive method of saliva collection and result detection which allows healthcare providers to send test kits to patient homes for remote testing, monitoring and care decisions. The apparatus includes a dental saliva imaging test card paired with a web application downloaded to a smartphone. The system may be used at home or in the dental office. The smartphone interface walks patients and providers through the test with tutorials to accurately capture testing results. The imaging test card includes a plurality of test strips onto which the patient places saliva. The test strips are sensitized to look for certain biomarkers, some of which detect periodontal disease and elevated caries risk. Results from the test strips are photographed and are then uploaded to the application for analysis.

6.20240249801CALIBRATING AN ELECTRONIC CHEMICAL SENSOR TO GENERATE AN EMBEDDING IN AN EMBEDDING SPACE
US 25.07.2024
Int.Class G16C 20/70
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
20Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
70Machine learning, data mining or chemometrics
Appl.No 18561610 Applicant Osmo Labs, PBC Inventor Alexander Wiltschko

Electronic chemical sensors can output raw electrical signal data in response to sensing a chemical compound, but the raw electrical signal data can be difficult to interpret. Processing the electrical signal data with a machine-learned model to generate an embedding output in an embedding space can provide a better understanding of the electrical signal data. Moreover, leveraging preexisting chemical property prediction models to generate other embeddings in the embedding space can allow for more accurate and efficient classification tasks of the electrical signal data.

7.102024101365TECHNIKEN ZUM VERRINGERN VON NULLVERLUST-PEAKS IN MONOCHROMATISCHEN QUELLEN GELADENER TEILCHEN
DE 25.07.2024
Int.Class H01J 37/26
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
37Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
26Electron or ion microscopes; Electron- or ion-diffraction tubes
Appl.No 102024101365 Applicant FEI COMPANY Inventor Henstra Alexander

Es werden optische Ladungsteilchenvorrichtungen, -systeme und -verfahren bereitgestellt. Eine optische Ladungsteilchenvorrichtung kann ein dispergierendes Element enthalten, das im Wesentlichen auf einer Strahlachse angeordnet ist, wobei das dispergierende Element so konfiguriert ist, dass es Teilchen eines Ladungsteilchenstrahls durch Energie in einer Streuebene parallel zur Strahlachse dispergiert. Die optische Ladungsteilchenvorrichtung kann einen Selektor beinhalten, der auf der Strahlachse in einer Position angeordnet ist, die im Wesentlichen einer ersten Kreuzungsebene entspricht. Die optische Ladungsteilchenvorrichtung kann ein dispersionsaufhebendes Element einschließen. Die optische Ladungsteilchenvorrichtung kann einen Cutoff beinhalten, der auf der Strahlachse stromabwärts des Selektors in einer Position angeordnet ist, die im Wesentlichen einer zweiten Kreuzungsebene auf der Strahlachse entspricht. Die zweite Kreuzungsebene kann stromabwärts der ersten Kreuzungsebene liegen. Der Cutoff kann ein Material enthalten, das für Elektronen undurchlässig ist, und eine Apertur definieren, die im Wesentlichen mit der Strahlachse ausgerichtet ist. embedded image

8.20240248084METHOD FOR USING BIOTIN-COATED SOLID SUPPORT IN BIOCHEMICAL ASSAYS BASED ON INTERFEROMETRY
US 25.07.2024
Int.Class G01N 33/557
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
557using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
Appl.No 18437032 Applicant ACCESS MEDICAL SYSTEMS, LTD. Inventor Robert F. Zuk

The present invention is directed to biochemical assay methods, which uses a biotin-immobilized solid support surface for quantitating an analyte or measuring kinetic binding in different samples, from about 3 to 20 times, while maintaining acceptable assay performance. The methods use a streptavidin capture solution comprising streptavidin or preferably streptavidin polymers. The biotin-immobilized solid support surface is regenerated after each cycle of reactions by contacting the surface in an acidic solution having pH about 1-4, followed by DMSO. The regeneration step removes the bound immunocomplex and leaves the biotin on the surface.

9.20240248096PROTEOMIC SCREENING FOR LYSOSOMAL STORAGE DISEASES
US 25.07.2024
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Appl.No 18435892 Applicant Seattle Children's Hospital d/b/a Seattle Children's Research Institute Inventor Sihoun Hahn

Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease.

10.WO/2024/152112G PROTEIN-COUPLED RECEPTOR (GPCR) ANTIBODIES COUPLED TO HOMOLOGOUS DIMERIZATION (HD) PEPTIDES
WO 25.07.2024
Int.Class C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Appl.No PCT/CA2024/050046 Applicant MORGAN, Alton C. Inventor MORGAN, Alton C.
G protein-coupled receptor (GPCR) antibodies coupled to an HD peptide are disclosed, as well as methods of manufacture and uses of said antibodies. The HD peptides may comprise (i) an amino acid sequence of a naturally occurring HD peptide, or a conservative variant thereof, (ii) an amino acid sequence having the reverse configuration compared to a corresponding naturally occurring HD peptide, or a conservative variant thereof; (iii) an amino acid sequence of a naturally occurring HD peptide with one or more hydrophilic substitutions, or (iv) an HD peptide dimer.