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Analysis

1.20240247323MULTIPLEXED PCR ASSAY WITH POINT OF CARE SAMPLE
US 25.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 17918802 Applicant ChromaCode, Inc. Inventor Aditya RAJAGOPAL

Methods, systems, compositions and kits for using a multiplexed assay on a sample that is obtained from a subject are disclosed. The methods, systems, compositions and kits may comprise obtaining a sample from a subject that is in a location distal from where the assay is performed. The subject may obtain the sample without the presence of another individual. The methods, systems, compositions and kits may allow an assay to be run without addition of a reagent after the sample is received from the subject and prior to running an assay.

2.WO/2024/152422HPV SCREENING METHOD BASED ON DNA OF MENSTRUAL BLOOD
WO 25.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/CN2023/080362 Applicant GENERULOR CO., LTD Inventor TIAN, Rui
An HPV screening method based on DNA of menstrual blood. The method comprises: extracting DNA of menstrual blood; constructing a DNA library having a sequencing adapter; hybridizing the DNA library with a human Cot-1 DNA blocking reagent and a probe to obtain a hybridization product; adding streptavidin magnetic beads into the hybridization product, and capturing DNA of a target region; and carrying out PCR amplification to obtain an on-machine library, and carrying out sequencing analysis. The present invention proposes a non-invasive self-sampling screening scheme of "collecting a sanitary napkin with menstrual blood, mailing same by express, and carrying out HPV detection based on HPV capture sequencing technology", and thus premenopausal women can participate in screening by mailing sanitary napkins on the second day of menstruation. The method solves the dilemmas of missed diagnosis, misdiagnosis and overtreatment in existing screening means.
3.WO/2024/152423PORTABLE DEVICE FOR COLLECTING MENSTRUAL BLOOD SAMPLE AND HPV RAPID DETECTION SYSTEM
WO 25.07.2024
Int.Class G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Appl.No PCT/CN2023/080364 Applicant GENERULOR CO., LTD Inventor TIAN, Rui
A portable device for collecting a menstrual blood sample and an HPV rapid detection system. The portable device comprises netted polyester fiber absorbent cotton used as a main body part of the portable device and an adhesive plaster on the back surface, wherein the surface of the adhesive plaster is covered with a PU film adhesive plaster, and an anti-adhesion covering film is attached to the surface of the PU film adhesive plaster. The portable device uses a completely non-invasive sampling mode, and an HPV screening sample can be obtained only by means of pasting a minipad on a suitable area of a sanitary towel on the second to third day of menstruation. Therefore, the portable device has the advantages of instant detection, being accurate, high levels of sensitivity, etc. During a detection process, gene editing is carried out on the basis of CRISPR-Cas12a, which can not only specifically recognize and cleave a target nucleic acid chain, but also cleave ssDNA adjacent to the target without distinction, so as to achieve instant screening of HPV.
4.20240247322METHODS AND COMPOSITIONS FOR DETECTING SARS-COV2 VIRUS OMICRON, ALPHA, BETA, DELTA, OR GAMMA
US 25.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 18157673 Applicant Universidad de Cartagena Inventor Doris Esther Gómez-Camargo

The present invention concerns methods for detecting SARS-CoV 2 virus omicron, alpha, beta, delta and/or gamma as well as kits for performing such methods.

5.WO/2024/154944METHOD AND CARTRIDGE FOR DIAGNOSING FOOT-AND-MOUTH DISEASE VIRUS USING SEMICONDUCTOR BIOSENSOR-BASED POLYMERASE CHAIN REACTION TECHNIQUE
WO 25.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/KR2023/020059 Applicant OPTOLANE TECHNOLOGIES INC. Inventor SHIN, Seung Shick
The present invention relates to a method for diagnosing foot-and-mouth disease (FMD) using a polymerase chain reaction (PCR) technique. This method is to provide a method for high-accuracy and multiplex diagnosis of the foot-and-mouth disease virus by utilizing a semiconductor biosensor PCR technique in foot-mouth disease diagnosis. According to the present invention, the method can satisfy both the simplicity and accuracy of early diagnosis of foot-and-mouth disease, thus playing a crucial role in preventing and controlling the spread of the virus through the diagnosis and management of foot-and-mouth disease virus and the prevention of infection spread of foot-and-mouth disease virus. Additionally, the present invention has high potential value in meeting the demands for on-site early diagnosis and diagnostic kits for foot-and-mouth disease.
6.20240241123SYSTEMS AND METHODS FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES
US 18.07.2024
Int.Class G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Appl.No 18618944 Applicant Analiza, Inc. Inventor Arnon Chait

Certain aspects of the present disclosure generally relate to systems and methods for determining viruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, the virus may partition into one or more phases. In some cases, a virus-binding moiety facilitates partitioning of the virus. The phases may be assayed to determine the virus based on, e.g., quantitative or qualitative assessments of the distribution of virus-binding and/or signaling moieties. The virus-binding moiety may be attached to particles that may form a complex around a virus. The complex may be detectable without a signaling moiety (e.g., as a color change) in some embodiments. In some cases, more than one virus may be determined. For example, a virus-binding moiety may substantially alter the partitioning behavior of one virus or complex, relative to another, by being selective for the first virus.

7.20240240266ISOTHERMAL GENE AMPLIFICATION METHOD, GENE DETECTION METHOD, VIRUS DETECTION METHOD, AND KIT USED THEREFOR
US 18.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 18562206 Applicant BioSeeds Corporation Inventor Manish BIYANI

An isothermal gene amplification method that allows an RNA virus to be detected easily and inexpensively in a short time is presented. The isothermal gene amplification method involves a target sequence in an RNA genome, and includes: (A) producing an amplification reaction template; (B) DNA amplifying for increasing the amplification reaction template; and (C) RNA amplifying.

8.20240240268SAMPLE COLLECTION DEVICES AND METHODS OF USING THE SAME
US 18.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 18289354 Applicant Salus Discovery, LLC Inventor Jay Warrick

Provided herein are sample collection devices and methods of using the same for collecting a sample from a subject. In some aspects, provided herein are wearable sample collection devices. In some embodiments, provided herein are face masks containing a sample collection device and methods of using the same for collection and/or assessment of a sample. In some aspects, provided herein are sample collection devices and methods of using the same for detecting a pathogen in a sample collected from a subject.

9.WO/2024/150786TARGET SUBSTANCE DETECTION REAGENT AND DETECTION METHOD
WO 18.07.2024
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No PCT/JP2024/000383 Applicant KIKKOMAN CORPORATION Inventor MAEDA Yasukazu
The present invention detects, with high sensitivity, a target, on the surface of which exist proteins such as microorganisms and viruses in high density. A first binding molecule and a second binding molecule bonded to a target substance approach each other such that an enzyme reaction caused an enzyme joined to each binding molecule progresses continuously. The enzyme reaction is measured optically.
10.20240240272TARGETED MASSIVELY PARALLEL SEQUENCING FOR SCREENING OF GENETIC HEARING LOSS AND CONGENITAL CYTOMEGALOVIRUS-ASSOCIATED HEARING LOSS
US 18.07.2024
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No 18289316 Applicant UNIVERSITY OF IOWA RESEARCH FOUNDATION Inventor Ryan K. THORPE

In certain embodiments, the present invention provides the design of a targeted, amplicon-based massively parallel sequencing (MPS) panel focusing on amplifying specific regions of interest associated with genetic hearing loss and infectious diseases associated with hearing loss. The present invention also provides the design of a bioinformatics pipeline capable of performing automated analysis of regions of interest generated by the amplicon-based MPS panel, a targeted gene panel, exome sequencing, or genome sequencing.