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IC:C12Q1/68

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Analysis

1 / 22,704
1.WO/2025/138284ARRAY AND METHOD FOR DETECTING SPATIAL INFORMATION OF NUCLEIC ACIDS
WO - 03.07.2025
Int.Class C12Q 1/6874
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
6874involving nucleic acid arrays, e.g. sequencing by hybridisation
 Appl.No PCT/CN2023/143677 Applicant BGI SHENZHEN Inventor LIAO, Sha
The present application provides a nucleic acid array for detecting spatial information of nucleic acids in a sample, a method for detecting spatial information of nucleic acids in a sample on the basis of the array, and a method for producing the nucleic acid array.
2.WO/2025/140249A CIRCULAR RNA AND RELEVANT CONSTRUCTS AND A METHOD USING THE SAME
WO - 03.07.2025
Int.Class C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
 Appl.No PCT/CN2024/142130 Applicant SUZHOU ABOGEN BIOSCIENCES CO., LTD. Inventor MA, Yu
Provided is a circular RNA which can be regulated by microRNAs, a pharmaceutical composition comprising the circular RNA and a method of using the same. Also provided is a method of enhancing targeting expression of circular RNA through microRNA regulation.
3.WO/2025/144719METHOD FOR AQUEOUS CONJUGATION OF SUBSTRATES
WO - 03.07.2025
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No PCT/US2024/061323 Applicant LIFE TECHNOLOGIES CORPORATION Inventor LI, Dong
A method for conjugating oligonucleotides to bead supports includes adding carbodiimide to an aqueous suspension including bread supports having carboxy functional groups; adding hydroxysuccinimide to the aqueous suspension; and adding amine modified oligonucleotide to the aqueous suspension.
4.WO/2025/145004METHODS, SYSTEMS, COMPOSITIONS AND KITS FOR TARGET DETECTION
WO - 03.07.2025
Int.Class C12Q 1/682
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
682Signal amplification
 Appl.No PCT/US2024/062056 Applicant PLENO, INC. Inventor VINCENT, Ludovic
Provided herein are methods, systems, compositions, and kits for detecting and decoding an encoded assay. The present disclosure provides low cost, multiplexed and automatable assays by hypercoding, a scalable technology for detection and quantitation of multi-omics targets. Hypercoding, or coding, utilizes signals from fluorescent hybridization with an error-corrected code to enable accurate detection and high-plexity targets of interest from samples. The present disclosure provides encoded assays for multiplex target detection from a sample suitable for detection by hybridization. Detection polynucleotide complexes, or detection oligonucleotides and anchor oligonucleotides, of the present disclosure are utilized in the detection and decoding of the hypercodes to produce optical signals capable of being decoded by a soft decision decoding algorithm for determining the presence of a target of interest, or multiple targets of interest, in a sample.
5.WO/2025/141959METHOD FOR PREDICTING PROMOTER ACTIVITY AND METHOD FOR MODIFYING PROMOTER BASED ON RESULTS OF PREDICTING PROMOTER ACTIVITY
WO - 03.07.2025
Int.Class C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
 Appl.No PCT/JP2024/030592 Applicant GRA&GREEN INC. Inventor TOYOKURA Koichi
The present disclosure provides a method for obtaining a promoter sequence modified so as to have a desired transcriptional activity. More specifically, provided is a method for obtaining a promoter sequence modified so as to have a desired transcription activity, the method comprising: preparing an original promoter sequence to be modified; generating a set of a plurality of modified promoter sequences that can be created by genome editing techniques on the basis of the promoter sequence; predicting, by a machine learning model, the transcription activity of each modified promoter sequence included in the set of modified promoter sequences generated; and selecting a modified promoter sequence predicted to have a desired active transcription performance.
6.WO/2025/141105SPECIFIC PROBES FOR THE DETECTION OF NUCLEIC ACIDS, METHODS AND USES
WO - 03.07.2025
Int.Class C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
 Appl.No PCT/EP2024/088487 Applicant BIOMÉRIEUX Inventor LAURENT, Alain
The invention relates to compounds FC having the formula (I), wherein Z, X, Re, Ri, Rj, Rk, n, R1, R2, R3 and R4, are as defined in claim 1, including their salts. The invention concerns also a detection probe PR labelled with at least one molecule of a compound FC according to the invention, comprising an oligonucleotide covalently coupled on the reactive group RG of said compound FC, the methods and kits using them.
7.WO/2025/145050REUSABLE SURFACE CHEMISTRY FOR SPATIAL SUBSTRATES
WO - 03.07.2025
Int.Class C12Q 1/6874
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
6874involving nucleic acid arrays, e.g. sequencing by hybridisation
 Appl.No PCT/US2024/062112 Applicant ILLUMINA, INC. Inventor SHEN, Fei
The present disclosure provides substrates, compositions, and methods for re-generating and reusing a substrate for spatially tagging a target molecule in a sample.
8.WO/2025/139269PCR DEVICE CALIBRATION METHOD, APPARATUS, SYSTEM, PCR DEVICE, AND STORAGE MEDIUM
WO - 03.07.2025
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
 Appl.No PCT/CN2024/126548 Applicant SANSURE BIOTECH INC. Inventor DAI, Lizhong
Provided are a PCR device calibration method, an apparatus, a system, and a PCR device. The calibration method comprises: controlling each channel to be tested to test a calibration fluorescent material in a well to be tested, so as to obtain first fluorescence data of said well; acquiring standard fluorescence data of the calibration fluorescent material; determining the proportion between the first fluorescence data and the standard fluorescence data; according to the proportion, determining an adjustment mode for a PCR device to be calibrated, the adjustment mode being a current adjustment mode and/or a gain adjustment mode; and according to the adjustment mode, adjusting the working current and/or working gain of the PCR device to be calibrated, so as to determine a target working current and a target working gain for the PCR device to be calibrated, such that each channel to be tested performs a fluorescence test under the target working current and the target working gain. For a multi-channel PCR device, the present invention adjusts working parameters by means of different modes, thereby improving the test accuracy of the PCR device.
9.WO/2025/144744ENRICHMENT OF CLONAL SUBSTRATES
WO - 03.07.2025
Int.Class C12Q 1/6853
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6853using modified primers or templates
 Appl.No PCT/US2024/061479 Applicant LIFE TECHNOLOGIES CORPORATION Inventor SZETO, Kylan
A method for enriching clonal populations includes, for a population of target nucleic acids, includes exposing the population of target nucleic acids to a plurality of supports; amplifying the bound target nucleic acids in the presence of a primer to form supports including a plurality of copies of the target nucleic acids of the population of target nucleic acids; applying to the supports a capture primer; applying a magnetic bead functionalize with a moiety to bind to the binder moiety; and separating the first set of supports from the second and third set of supports.
10.WO/2025/140140SAMPLE TESTING DEVICE, AND EXTRACTOR
WO - 03.07.2025
Int.Class C12M 1/38
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
36including condition or time responsive control, e.g. automatically controlled fermentors
38Temperature-responsive control
 Appl.No PCT/CN2024/141608 Applicant SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. Inventor LI, Zhaoyang
A sample testing device and an extractor. The sample testing device comprises a reagent storage component, a reagent dispensing component, a sample dispensing component, an extraction component, an amplification component, a testing component, a first liquid transfer component, a dispatching component, and a controller, wherein the reagent dispensing component dispenses a first reagent into a first cavity in an extractor, and dispenses a second reagent into a second cavity in the extractor; the sample dispensing component is configured to dispense a sample into the extractor; the extraction component is configured for nucleic acid extraction of a liquid in the extractor; the first liquid transfer component is configured to transfer the liquid from the extractor to an amplification tube; the amplification component and the testing component are configured for amplification and testing of the liquid in the amplification tube; and the dispatching component is configured for dispatching the extractor, such that after at least part of the liquid after the completion of the nucleic acid extraction in the first cavity is transferred to the amplification tube by the first liquid transfer component, the second reagent in the second cavity is also transferred to the amplification tube by the first liquid transfer component.
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