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Analysis

1.20230036629METHODS FOR INHIBITING GROWTH OF ORAL PATHOGENIC BACTERIA AND ALLEVIATING ORAL PATHOGENIC BACTERIA-ASSOCIATED DISORDER
US 02.02.2023
Int.Class A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
Appl.No 17573049 Applicant GLAC BIOTECH CO., LTD. Inventor Hsieh-Hsun Ho

Disclosed herein are methods for inhibiting growth of oral pathogenic bacteria and alleviating an oral pathogenic bacteria-associated disorder using a culture of at least one lactic acid bacterial strain selected from the group consisting of Lactobacillus rhamnosus MP108 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 21225, and Lactobacillus paracasei MP137 which is deposited at the CGMCC under an accession number CGMCC 21224.

2.20230031597BIASED IL2 MUTEINS METHODS AND COMPOSITIONS
US 02.02.2023
Int.Class A61K 38/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
Appl.No 17833235 Applicant Synthekine, Inc. Inventor Jan Emmerich

The present disclosures related to human interleukin-2 (hIL2) muteins, pharmaceutical formulations thereof, methods for preparing interleukin-2 muteins, recombinant vectors and cells comprising nucleic acids encoding IL2 muteins and methods for the treatment of human disease.

3.WO/2023/009439MECHANOTRANSDUCTION DISRUPTION MEDIATION IN SKIN GRAFTING METHODS AND COMPOSITIONS FOR USE IN PRACTICING THE SAME
WO 02.02.2023
Int.Class A61L 27/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
Appl.No PCT/US2022/038189 Applicant THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Inventor GURTNER, Geoffrey
Skin graft methods are provided. Aspects of the methods include applying a skin graft to a wound in combination with a mechanotransduction blocker, such as a pharmacological mechanotransduction blocker, e.g., a focal adhesion kinase inhibitor. Also provided are compositions and kits for use practicing methods of the invention.
4.WO/2023/009874COMPOSITIONS COMPRISING EXTRACELLULAR VESICLES, SECRETED BIOMOLECULES, AND/OR CONDITIONED MEDIA, AND METHODS OF PRODUCING AND USING THE SAME
WO 02.02.2023
Int.Class A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
Appl.No PCT/US2022/038967 Applicant L'OREAL Inventor ROY, Daniel Christopher
The disclosure relates to novel compositions comprising 1) conditioned media, 2) combinations of secreted biomolecules/organic molecules, and/or 3) secreted extracellular vesicles/exosomes collected from differentiated epithelial cell culture, as well as methods of making and using such compositions.
5.WO/2023/009844METHODS AND COMPOSITIONS FOR USING ACTIVATED LYMPHOCYTES IN THE TREATMENT OF DISEASE
WO 02.02.2023
Int.Class A61K 35/768
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
768Oncolytic viruses not provided for in groups A61K35/761-A61K35/76697
Appl.No PCT/US2022/038917 Applicant IMMUNOLUX INTERNATIONAL CORP. Inventor SZALAY, Aladar A.
Described herein are methods and compositions for treating a disease, e.g. cancer (including solid tumors) inflammatory disease, autoimmune disease, or fibrosis. Method for treating a disease in a subject, the method including administering to the subject a composition containing an oncolytic virus and an immune cell, wherein the immune cell is infected with an oncolytic virus.
6.WO/2023/010114MONITORING AND MANAGEMENT OF CELL THERAPY-INDUCED TOXICITIES
WO 02.02.2023
Int.Class G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Appl.No PCT/US2022/074306 Applicant KITE PHARMA, INC. Inventor SONG, Qinghua
The present disclosure relates generally to compositions and methods for identifying cell therapy patients as being likely or not likely to experience toxicity following the cell therapy. The methods are based on the discovery that pre-treatment covariates, such as serum IL- 15 and MCP-1 levels in the patients or the viability of the cells being administered can be used predict the likelihood of the onset of such toxicities. Once the patient is identified as being likely or not likely to experience the toxicities, compositions and methods are also provided for monitoring and managing the toxicities.
7.20230032299WOUND DRESSING COMPRISING A COMBINATION OF HYDROGEL AND HONEY, METHOD OF PREPARATION AND USES THEREOF
US 02.02.2023
Int.Class A61F 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
13Bandages or dressings; Absorbent pads
Appl.No 17777955 Applicant Sion Biotext Medical Ltd. Inventor Daniel Lev

The present disclosure provides a wound dressing composition comprising cross-linked hydrogel scaffold and embedded therein anti-bacterially active honey, said activity being determined by the detection of hydrogen peroxide production rate by said wound dressing; said wound dressing further comprising at least one of a photo-initiator and/or at least one UV cross linker, the total amount of said photo-initiator and/or UV cross linker is equal or less than 0.2% w/w out of the total weight of the wound dressing. Also disclosed herein is a method of preparing the wound dressing and methods of using the same with respect to wounds, the method of preparation comprises mixing a hydrogel forming mixture comprising hydrogel forming monomer or monomers, honey and at least one photo-initiator and/or at least one UV cross-liker to form a homogenous mixture; and subjecting the homogenous mixture to UV irradiation until said homogenous mixture solidifies.

8.WO/2023/009125DELIVERY SYSTEM AND METHODS FOR USING SAME
WO 02.02.2023
Int.Class A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
Appl.No PCT/US2021/043747 Applicant COLLAGEN MATRIX, INC. Inventor CHEN, Hui-Chen
A delivery system for delivering at least one biological substance to a diseased or damaged area of a patient and having a sponge including a top sponge portion with a plurality of protrusions extending downwardly therefrom and a bottom sponge portion having a plurality of wells formed therein, the wells being configured to receive the at least one biological substance therein. Each of the plurality of wells is dimensioned to receive one of the plurality of protrusions therein upon placing the top sponge portion onto the bottom sponge portion to assemble the sponge. Also disclosed is a method for delivering the biological substance(s) to the diseased or damaged area of a patient using the delivery system, and a kit including the biological substance(s) and the delivery system.
9.20230036065METHODS FOR CANCER IMMUNOTHERAPY
US 02.02.2023
Int.Class A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Appl.No 17782607 Applicant Precision BioSciences, Inc. Inventor Bruce J. McCreedy, Jr.

The present invention encompasses methods of cancer immunotherapy, and particularly methods of allogeneic cellular immunotherapy, using particular lymphodepletion regimens in combination with particular populations of chimeric antigen receptor T cells expressing anti CD19 CAR PBCAR0191, anti CD20 CAR PBCAR20A or anti BCMA CAR PBCAR269A.

10.20230036959BILE TOLERANT PROBIOTICS TO INHIBIT ENTERIC PATHOGENS
US 02.02.2023
Int.Class C12Q 1/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
Appl.No 17790934 Applicant SOUTH DAKOTA BOARD OF REGENTS TECHNOLOGY TRANSFER OFFICE Inventor Joy Scaria

A composition and method for identifying a microbial composition that inhibits colonization of an enteric pathogen in an animal is disclosed. The method includes removing a microbial sample from a digestive tract of at least one healthy individual, culturing the microbial sample, isolating one or more microbial species within the microbial sample, and identifying one or more isolated microbial species. The method further includes determining one or more bile-tolerant properties of the one or more isolated microbial species, and creating one or more microbial compositions of the one or more isolated microbial species that are bile-tolerant. The method further includes determining an ability of the one or more microbial compositions to inhibit growth of an enteric pathogen in at least one of an assay, and identifying one or more microbial compositions from the one or more microbial compositions capable of inhibiting growth of enteric pathogens in an animal.