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1.WO/2022/012216DNA MOVABLE TYPE STORAGE SYSTEM AND METHOD
WO 20.01.2022
Int.Class G06F 16/172
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
16Information retrieval; Database structures therefor; File system structures therefor
10File systems; File servers
17Details of further file system functions
172Caching, prefetching or hoarding of files
Appl.No PCT/CN2021/098663 Applicant BEIJING INSTITUTE OF GENOMICS CHINESE ACADEMY OF SCIENCES / CHINA NATIONAL CENTER FOR BIOINFORMATION Inventor CHEN, Fei
A DNA movable type storage system and method. The method comprises: providing a content movable type physical library and an index movable type physical library; splitting data to be stored in a target file into a plurality of data elements and marking index information for the data elements, enabling content information of the data elements to correspond to specific content movable type oligonucleotide fragments in the content movable type physical library, and enabling the index information to correspond to specific index movable type oligonucleotide fragments in the index movable type physical library; and then, connecting the content movable type oligonucleotide fragments and the index movable type oligonucleotide fragments to form DNA movable type units, and a plurality of DNA movable type units forming a DNA storage file in which all data elements to be stored are stored. A DNA movable type physical library can be synthesized in one step, multiple instances of repeated usage and free combination greatly reduce the DNA synthesis costs, the labor and time investment involved in multiple instances of designing and synthesis of DNA fragments can be avoided, and the cost burden caused due to the introduction of a large number of error correction sequences is avoided.
2.WO/2022/015651PREDICTION OF PEPTIDE CLEAVAGE IN POLYPEPTIDES THROUGH PHYSICS-BASED SIMULATIONS
WO 20.01.2022
Int.Class G16B 15/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
15ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
Appl.No PCT/US2021/041289 Applicant GENENTECH, INC. Inventor RAJAGOPAL, Karthikan
The present disclosure relates to polypeptide degradation, and in particular to techniques for predicting the likelihood that a peptide bond for a given polypeptide molecule is susceptible to a cleavage reaction. Particularly, aspects of the present disclosure are directed to generating a representation of a polypeptide, performing a molecular-dynamics simulation using the representation to obtain a set of polypeptide conformations, determining, for each polypeptide conformation, a spatial characteristic of an amino acid, estimating a nucleophilic attack distance of each polypeptide conformation based on the spatial characteristic, identifying a reactive conformation that is susceptible to a cleavage reaction based on the nucleophilic attack distance of each polypeptide conformation, determining a free energy of the spatial characteristic of the amino acid in the reactive conformation; and predicting a probability of the side chain of the amino acid being trapped in the reactive conformation based on the free energy.
3.WO/2022/011457TRANSGENIC ANIMALS EXPRESSING HEAVY CHAIN ANTIBODIES
WO 20.01.2022
Int.Class C12N 15/85
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
Appl.No PCT/CA2021/050951 Applicant KISOJI BIOTECHNOLOGY INC. Inventor HOU, Wenyang
The present disclosure generally relates to transgenic animals comprising germline modifications at an immunoglobulin heavy chain (IgH) locus for expressing heavy chain antibodies (HCAbs) as well as nucleic acid constructs, cells and methods for generating same. The present disclosure also relates to binding agents comprising sequences derived from the heavy chain antibodies produced by the transgenic animals.
4.WO/2022/013781PEPTIDE EPITOPE VACCINES FOR COVID-19 AND METHOD OF DESIGNING, MAKING AND USING THE SAME
WO 20.01.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/IB2021/056355 Applicant UNIVERSITY OF SOUTHERN CALIFORNIA Inventor BOGDAN, Paul
Computer systems and computer implemented methods are presented for designing and making vaccines to pathogens, particular viral pathogens. Vaccine compositions for COVID-19 are also disclosed, as well as method of using the same.
5.WO/2022/015820IDENTIFICATION OF GENOME REGIONS ASSOCIATED WITH KIDNEY DISEASE AND TREATMENT
WO 20.01.2022
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
Appl.No PCT/US2021/041581 Applicant THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL Inventor SMOYER, William E.
Methods of identifying one or more genomic regions associated with kidney disease and/or its treatment are described. The methods include administering a glucocorticoid to a first group of subjects; administering a thiazolidinedione to a second group of subjects; and identifying a plurality of genomic regions affected in the first group and the second group, wherein the subjects have a kidney disease or are animal models of a kidney disease. Methods of identifying a drug for treatment of nephrotic syndrome are also described.
6.WO/2022/015998GENE PANELS AND METHODS OF USE THEREOF FOR SCREENING AND DIAGNOSIS OF CONGENITAL HEART DEFECTS AND DISEASES
WO 20.01.2022
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
Appl.No PCT/US2021/041853 Applicant UNIVERSITY OF CONNECTICUT Inventor COTNEY, Justin L.
The present disclosure relates to gene panels and methods of use thereof for the assessment of risk of congenital heart defect or disease in a subject.
7.WO/2022/011855FALSE POSITIVE STRUCTURAL VARIATION FILTERING METHOD, STORAGE MEDIUM, AND COMPUTING DEVICE
WO 20.01.2022
Int.Class G16B 40/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Appl.No PCT/CN2020/120315 Applicant XI'AN JIAOTONG UNIVERSITY Inventor ZHENG, Tian
Disclosed are a false positive structural variation filtering method, a storage medium and a computing device. The method comprises: firstly acquiring a structural variation candidate set; then performing feature extraction; migrating feature data of different purities; performing extra tree model classification; and predicting a classification result in order to realize false positive structural variation filtering. In the present invention, an initial feature is extracted from a structural variation detection result file, and by combining a transfer component analysis method and an extra tree model, the same model can be used to adapt well to structural variation detection samples of sequencing signals which are diluted at different degrees, and the accuracy of filtering is higher and more stable.
8.WO/2022/013025METHOD FOR DETERMINING THE DIFFERENTIATION STATE OF A STEM CELL
WO 20.01.2022
Int.Class G16B 25/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
25ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
30Microarray design
Appl.No PCT/EP2021/068758 Applicant KONINKLIJKE PHILIPS N.V. Inventor VAN DE STOLPE, Anja
The present invention relates to a method for determining the differentiation state of a stem cell, based on cellular signaling pathway activities. The method can be used to determine the pluripotency, multipotency or unipotency of a stem cell. The invention further relates to a method for generating a reference library for use in the method for determining the differentiation state. The invention further relates a non-transitory storage medium for executing the method, a kit of parts suitable for performing the method and use of the kit of parts in performing the method of the invention.
9.WO/2022/011477METHODS FOR CLASSIFYING CANCER
WO 20.01.2022
Int.Class C12Q 1/6809
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6809Methods for determination or identification of nucleic acids involving differential detection
Appl.No PCT/CA2021/050982 Applicant QUEEN'S UNIVERSITY AT KINGSTON Inventor RENWICK, Neil
Methods for classifying neuroendocrine neoplasms (NENs) are based on comprehensive microRNA (miRNA) expression profiling and data mining of multiple pathological types. Reference miRNA expression profiles are generated for multiple NEN pathological types and site‐matched non‐NEN controls, and candidate category and type specific miRNAs are identified and used for 5 classification. A multilayer hierarchical classifier for discriminating NEN pathological types is based on the candidate category and type specific miRNAs. Methods and software products include products that enable construction of discriminator functions including hierarchical classifiers for discriminating among multiple conditions of interest in a dataset, the methods and software products being applicable to a wide range of data modalities, including, for example, omics data 0 such as miRNA expression data wherein multiple conditions of interest include different cancer pathologies.
10.WO/2022/013186METHOD FOR PREDICTION OF THE GUIDE EFFICIENCY WHEN TARGETING A GENE OF INTEREST
WO 20.01.2022
Int.Class G16B 40/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
40ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
20Supervised data analysis
Appl.No PCT/EP2021/069400 Applicant HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH Inventor BARQUIST, Lars
The present invention relates to a Method for prediction of the targeting efficiency of guides comprising guide RNA (gRNA) targeting a gene of interest, said guides locating a respective gene of interest as a target in a gene sequence, by evaluating data provided by screens, the screens providing levels of targeting characteristics efficiency of guides comprising the level of targeting efficiency confounded with gene-specific effects. The method comprising the steps of a) Selecting a set of guides along with a first set of gene intrinsic features related to their respective gene of interest, and a second set of guide features; b) Inputting the selected first set of gene intrinsic features and the selected second set of guide features into an automated machine learning algorithm and c) Calculating an estimate of targeting efficiency of said selected guides by use of the automated machine learning algorithm, wherein the automated machine learning algorithm comprising two models being separately trained from each other, wherein the first of the two models using the selected first set of gene intrinsic features and the second of the two models using the selected second set of guide features, and wherein the automated learning algorithm combines the two models with the result of a prediction of the depletion of the guides targeting the gene of interest.