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Analysis

1.WO/2022/012292PERIPHERAL BLOOD TCR MARKER FOR PANCREATIC CANCER, AND DETECTION KIT AND USE THEREOF
WO 20.01.2022
Int.Class G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Appl.No PCT/CN2021/101981 Applicant CHENGDU EXAB BIOTECHNOLOGY CO., LTD Inventor ZHANG, Zhixin
Provided are a peripheral blood TCR marker for pancreatic cancer, and a detection kit and the use thereof. The marker comprises at least one protein, the sequences of which are shown as SEQ ID NO. 1-100. The method is performed on the basis of a high-throughput sequencing method, wherein only a small amount of peripheral blood needs to be collected to extract RNA; a sample is treated to establish an immune map library; high-throughput sequencing and TCR data analysis are carried out to determine a characteristic TCR sequence in peripheral blood of pancreatic cancer; and the test result of a sample to be tested is then compared with the characteristic TCR sequence so as to determine whether pancreatic cancer is present or not.
2.WO/2022/013012METHOD AND DEVICE FOR EXAMINING A SAMPLE USING SPIN-DEPENDENT FLUORESCENCE
WO 20.01.2022
Int.Class G01N 21/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
Appl.No PCT/EP2021/068670 Applicant CARL ZEISS AG Inventor TRAUTMANN, Nils
The invention relates to methods and devices for examining samples which emit spin-dependent fluorescence. A measurement of the spin-dependent fluorescence (60) and/or an analysis of the measurement (65) is carried out using information on the time curve of the fluorescence (61). The analysis of the measurement using the information on the time curve (61) includes the process of weighting the measurement (64) using a weighting function which is based on the information on the time curve.
3.WO/2022/013297METHOD, DEVICE AND COMPUTER PROGRAM FOR REPAIRING A MASK FOR LITHOGRAPHY
WO 20.01.2022
Int.Class G03F 1/24
GPHYSICS
03PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
FPHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
1Originals for photomechanical production of textured or patterned surfaces, e.g. masks, photo-masks or reticles; Mask blanks or pellicles therefor; Containers specially adapted therefor; Preparation thereof
22Masks or mask blanks for imaging by radiation of 100 nm or shorter wavelength, e.g. X-ray masks, extreme ultra-violet masks; Preparation thereof
24Reflection masks; Preparation thereof
Appl.No PCT/EP2021/069617 Applicant CARL ZEISS SMT GMBH Inventor BAUER, Markus
A method, a device and a computer program for repairing a mask for lithography, in particular a mask for EUV lithography, are described. A method of repairing a mask for lithography, in particular a mask for EUV lithography, comprises the following steps: ascertaining a first value of an edge position of a structure to be repaired on the mask, carrying out a repair process, comprising at least one first repair step on the mask, ascertaining a second value of the edge position after carrying out the first repair step and comparing the second value of the edge position with the first value of the edge position and/or with a target value for the edge position.
4.WO/2022/013627SOIL ANALYSIS METHODS
WO 20.01.2022
Int.Class G01N 1/40
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
40Concentrating samples
Appl.No PCT/IB2021/054348 Applicant PRECISION PLANTING LLC Inventor PETROSKI, Richard
Described herein is a method of analyzing nutrient content in soil, the method comprising a) obtaining a soil sample, b) adding a liquid to the soil sample to form a soil slurry, c) flowing the soil slurry through a filter, whereby the filter is oriented such that the soil slurry flows downward through the filter at least partially under the effects of gravity, d) blending a reagent composition with the soil slurry to form a soil mixture, and e) measuring an absorbance of the soil mixture.
5.WO/2022/013762METHODS AND KITS FOR THE DIAGNOSIS OF LUNG CANCER
WO 20.01.2022
Int.Class G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Appl.No PCT/IB2021/056326 Applicant PINTO, Aldo Inventor PINTO, Aldo
The present invention relates to a method for the diagnosis and/or to monitor the development and/or to provide a prognosis on the development of lung cancer in an individual, including the detection of the expression levels of the isoform 4 of the human caspase-4 protein in biological samples. The present invention further relates to a kit and reagents for the detection of the expression levels of said isoform 4, as well as a compound inhibitor of said isoform 4 for use in the treatment and/or prevention of lung cancer.
6.WO/2022/014512METHOD AND DEVICE FOR DETERMINING KETOSIS MORBIDITY
WO 20.01.2022
Int.Class G01N 19/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
19Investigating materials by mechanical methods
Appl.No PCT/JP2021/026065 Applicant NATIONAL AGRICULTURE AND FOOD RESEARCH ORGANIZATION Inventor NAKAKUBO Ryoh
The present invention addresses the problem of making it possible to conveniently determine, in the field, etc., ketosis morbidity and/or the possibility of ketosis morbidity in an animal. The present invention also addresses the problem of providing a device for performing said determination. A method for determining ketosis morbidity according to an embodiment of the present invention comprises presenting a gas generated from a body fluid collected from an animal (non-human) to a gas detection means, and using the response of the gas detection means to the gas generated from the body fluid to determine ketosis morbidity in the animal on the basis of the composition of the gas generated from the body fluid.
7.WO/2022/014707TRPV4 INHIBITOR AS THERAPEUTIC DRUG FOR EYE DISEASE
WO 20.01.2022
Int.Class A61K 45/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
Appl.No PCT/JP2021/026829 Applicant RAQUALIA PHARMA INC. Inventor OHARA Kentaro
The present invention relates to the use of a compound having TRPV4 inhibitory activity, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing these, in the manufacture of a pharmaceutical product for the prevention or treatment of retinal disease that accompanies vascular disorders or cellular disorders. Further, the invention relates to a method of preventing or treating the aforementioned diseases, involving administering said compound or a pharmaceutical composition containing the same to a human or animal. Said compound, pharmaceutically acceptable salt thereof, or pharmaceutical composition containing these may be used in combination with one or more second active drugs. The invention relates to a kit and a pharmaceutical composition, used for the prevention or treatment of the aforementioned diseases and containing a compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof. The invention further relates to a marker for diagnosing diseases usefully treated by said compound, and a method for screening drugs that prevent or treat the aforementioned diseases.
8.WO/2022/015532COMPOSITIONS AND METHODS FOR DETECTING GENE FUSIONS OF RAD51AP1 AND DYRK4 AND FOR DIAGNOSING AND TREATING CANCER
WO 20.01.2022
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/US2021/040463 Applicant UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION Inventor WANG, Xiaosong
Provided herein are compositions and methods for detecting RAD51AP1-DYRK4 fusions in a subject or tissue. In some embodiments, the subject or tissue is treated with an MEK inhibitor when a RAD51AP1-DYRK4 fusion is detected therein. Accordingly, included herein are methods for treating cancer in a subject using an MEK inhibitor and for identifying subjects that will be responsive to MEK inhibitor therapy.
9.WO/2022/015622GAS MONITORING SYSTEMS AND METHODS
WO 20.01.2022
Int.Class G01N 1/22
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
02Devices for withdrawing samples
22in the gaseous state
Appl.No PCT/US2021/041220 Applicant CAST ENVIRONMENTAL, LLC Inventor CASSANI, Marcelo
Autonomous systems and methods to measure contaminants in a contaminated gas stream and provide feedback to a control system to reduce the unit usage when contaminants are present in specific detectable quantities or in quantities lower than the anticipated limits are disclosed. Disclosed embodiments monitor a gas stream input and/or input and output continuously or at predefined intervals adjustable by the user on odor control or air emission treatment equipment. Disclosed monitoring systems clean a gas sensor probe/detector by cycling the input stream to the sensor between a contaminated gas sample and cleaning air. Retrofittable monitoring system kits are also disclosed to achieve advantages described herein with previously installed monitoring and treatment systems.
10.WO/2022/015697FULLY COMPENSATED OPTICAL GAS SENSING SYSTEM AND APPARATUS
WO 20.01.2022
Int.Class G01N 21/3504
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
35using infra-red light
3504for analysing gases, e.g. multi-gas analysis
Appl.No PCT/US2021/041378 Applicant ANALOG DEVICES, INC. Inventor DELIWALA, Shrenik
System and apparatus for robust, portable gas detection. Specifically, this disclosure describes apparatuses and systems for optical gas detection in a compact package using two optical pathways. There is a need for a very compact, low-power, gas detection system for gases such as CO2, NOx, water vapor, methane, etc. This disclosure provides an ultra-compact and highly stable and efficient optical measurement system based on principals of optical absorption spectroscopy using substantially collinear pathways.