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Analysis

1.WO/2022/012037PCR DETECTION KIT FOR RAPID DETECTION OF SALMONELLA AND IDENTIFICATION OF SALMONELLA PULLORUM AND SALMONELLA GALLINARUM AND USE THEREOF
WO 20.01.2022
Int.Class C12Q 1/689
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
Appl.No PCT/CN2021/075498 Applicant YANGZHOU UNIVERSITY Inventor JIAO, Xin'an
The present invention provides a PCR detection kit for detection and identification of Salmonella pullorum/Salmonella gallinarum and a use thereof. By means of designing a primer for a cigR gene, the present invention utilizes PCR detection technology to conduct a cigR genetic test. According to amplification and detection conditions, analysis is conducted to determine whether the test subject is a Salmonella or if the test subject is Salmonella pullorum/Salmonella gallinarum. In specific implementation, the detection kit comprises at least the forward primer shown in SEQ ID NO: 1 and the reverse primer shown in SEQ ID NO: 2.
2.WO/2022/015532COMPOSITIONS AND METHODS FOR DETECTING GENE FUSIONS OF RAD51AP1 AND DYRK4 AND FOR DIAGNOSING AND TREATING CANCER
WO 20.01.2022
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/US2021/040463 Applicant UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION Inventor WANG, Xiaosong
Provided herein are compositions and methods for detecting RAD51AP1-DYRK4 fusions in a subject or tissue. In some embodiments, the subject or tissue is treated with an MEK inhibitor when a RAD51AP1-DYRK4 fusion is detected therein. Accordingly, included herein are methods for treating cancer in a subject using an MEK inhibitor and for identifying subjects that will be responsive to MEK inhibitor therapy.
3.WO/2022/015667CDNA SPIKE-IN CONTROL FOR SINGLE CELL ANALYSIS
WO 20.01.2022
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/US2021/041327 Applicant BECTON, DICKINSON AND COMPANY Inventor CAMPBELL, Tracy
Disclosed herein include systems, methods, compositions, and kits for determining the presence of a single cell mRNA sequencing assay workflow failure, including determining a failure in barcoding copies of a nucleic acid target and determining a failure in sequencing library generation. There are also provided, in some embodiments, compositions, methods, and systems for determining the sequencing status of sequencing library members (e.g., saturated sequencing or under sequencing). Compositions comprising a predetermined copy number of barcoded control nucleic acids are also provided herein.
4.WO/2022/016057METHODS OF ASSESSING QUALITY OF CELLS DURING A MANUFACTURING PROCESS
WO 20.01.2022
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
Appl.No PCT/US2021/041982 Applicant LIFEVAULT BIO, INC. Inventor HAMILTON, Jonathan, B.
Disclosed herein are methods for assessing the quality of cells received during various stages of a cell manufacturing process, and related methods of improving or optimizing a cell manufacturing process.
5.WO/2022/014991PATHOLOGICAL GRADE-SPECIFIC MARKER FOR MAKING PROGNOSIS OF AND DETERMINING TREATMENT STRATEGY FOR PROSTATE CANCER PATIENT
WO 20.01.2022
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Appl.No PCT/KR2021/008898 Applicant THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION Inventor CHOI, Yeong Jin
The present invention relates to a marker for predicting a difference in the effects of prostate cancer treatments and making a prognosis in accordance with the pathological grade of a prostate cancer patient. Since a genetic mutation of the present invention is respectively correlated with a survival rate and a recurrence rate of a prostate cancer patient of a particular pathological grade, the mutated gene of the present invention can be used as a marker for predicting a difference in the effects of prostate cancer treatments or a prognosis of the prostate cancer patient, on the basis of the pathological grade.
6.WO/2022/013452GENE LEADING TO TOBRFV RESISTANCE IN S. LYCOPERSICUM
WO 20.01.2022
Int.Class A01H 1/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
1Processes for modifying genotypes
04Processes of selection
Appl.No PCT/EP2021/070104 Applicant RIJK ZWAAN ZAADTEELT EN ZAADHANDEL B.V. Inventor KALISVAART, Jonathan
The invention relates to a Solanum lycopersicum plant that is resistant to ToBRFV, which plant comprises a QTL on chromosome 8 between SEQ ID No. 1 and 4. The presence of the QTL on chromosome 8 is identified by use of at least one of the markers selected from the group 5 consisting of the SNP presented in SEQ ID Nos. 1 to 42. The QTL is present in the genome of a Solanum lycopersicum plant representative seed of which was deposited with the NCIMB under deposit number NCIMB 43637.
7.WO/2022/013451MOLECULAR PROBE FOR NUCLEIC ACID DETECTION, PREPARATION AND USE THEREOF
WO 20.01.2022
Int.Class A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Appl.No PCT/EP2021/070059 Applicant GE HEALTHCARE AS Inventor ZHAO, Zhoushe
The present disclosure relates to molecular probes for nucleic acid detection, and preparation and uses thereof. In particular, described herein is a molecular probe for detection of a nucleic acid, comprising, (1) a molecular probe carrier which comprises a cell penetrating peptide and a detectable label coupled to the cell penetrating peptide, and (2) a targeting oligonucleotide, wherein the targeting oligonucleotide is attached to the molecular probe carrier. Also described herein are a method for preparing the molecular probe, a method for detection of a nucleic acid, and a kit for detection of a nucleic acid.
8.WO/2022/013886A SYSTEM AND A METHOD FOR THE DIAGNOSIS OF AN INFECTIOUS DISEASE
WO 20.01.2022
Int.Class C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
Appl.No PCT/IN2021/050677 Applicant SHARMA, Swarkar Inventor SHARMA, Swarkar
The present invention provides a system and a method for the diagnosis of an infectious disease by a novel nested loop-mediated isothermal amplification method with higher sensitivity and higher specificity. The system includes the designing of a plurality of primers based on the plurality of target regions of the target genome. The method employs a technique of reverse transcriptase-loop-mediated isothermal amplification (RT-LAMP), loop-mediated isothermal amplification (LAMP) and nested loop-mediated isothermal amplification (LAMP). The present method provides the system and the method for the diagnosis of an infectious disease from a small microbial load, thereby allowing diagnosis at an early stage of infection.
9.WO/2022/015146HYBRIDISATION METHOD FOR THE DETECTION OF NUCLEIC ACIDS USING FUNCTIONALISED MAGNETIC PARTICLES
WO 20.01.2022
Int.Class C12Q 1/6834
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
Appl.No PCT/MX2021/050028 Applicant UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO Inventor FIORDELISIO COLL, Tatiana
The present invention relates to a hybridisation method for the detection of nucleic acids, which comprises the steps of: (a) extracting a sample containing the genetic material to be detected, either DNA or RNA; (b) attaching magnetic particles to a synthetic oligonucleotide chain, wherein the surface of said magnetic particles is coated with a protein and said synthetic oligonucleotide chain has a binding tag, such that the binding of the protein to the oligonucleotide is called a functionalisation reaction, obtaining functionalised magnetic particles in this step; (c) incubating the sample containing the material to be detected (nucleic acids, either DNA or RNA) with a complementary strand oligonucleotide probe with a fluorescent tag, this reaction is referred to as competition reaction; and (d) making the functionalised magnetic particles obtained in step (b) react with a probe-target pair obtained in step (c), said step being referred to as the detection reaction.
10.WO/2022/015251A DETECTION DEVICE AND METHOD FOR RESPIRATORY VIRUSES
WO 20.01.2022
Int.Class A61K 35/76
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
Appl.No PCT/TR2020/050623 Applicant MICRONE SAGLIK VE BILISIM TEKNOLOJILERI A.S. Inventor TURHAN, Hatice
The invention relates to a detection device that comprises a housing (20), a slot (22) provided on the housing (20) into which a container (40) can be removably disposed, in which a mixture of biological material taken up containing an organic material degrading buffer fluid (3) and a marker (4) preferably selected as fluorescent is provided, and particle manipulator (60) in which the marker (4) is applied to the biomolecules exposed by the buffer liquid (3) in the container (40), and provided adjacent the slot (22) to direct the electrically charged target molecules (5) towards a predetermined deposition zone (z) within its domain, and its relevant method thereof. Detection device comprises a container (40) provided with a mixture containing a fluorescent marker (4) with an oligonucleotide sequence that is 50% identical to at least one of the genomic DNA/RNA, DNA or RNA sequence SEQID NO:1, SEQID NO:2, and SEQID no:3, and at least one lens (52) that is visually accessible from a front portion of the slot (22) towards the deposition zone (z) and with an adjusted focal length (f) to optically enlarge the focusing zone with respect to the deposition zone (z).