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Analysis

1.WO/2022/014620SARS-CoV-2 VACCINE
WO 20.01.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/JP2021/026368 Applicant BIOCOMO INCORPORATION Inventor FUKUMURA Masayuki
A vaccine that comprises, as an active ingredient, a viral vector which comprises a sequence containing any of the following amino acid sequences (a) to (c) and in which an induced neutralizing antibody presents, on the viral particle envelope, a protein inhibiting the binding of SARS-CoV-2 receptor binding domain (RBD) to human angiotensin-converting enzyme 2 (hACE2). (a) An amino acid sequence represented by SEQ ID NO: 1; (b) an amino acid sequence represented by SEQ ID NO: 1 in which one to several amino acids have been deleted, inserted, substituted or added; and (c) an amino acid sequence having a sequence identity of 80% or more to the amino acid sequence represented by SEQ ID NO: 1.
2.WO/2022/013609SARS-COV-2 VACCINE COMPOSITIONS AND METHODS OF PREPARATION AND USE
WO 20.01.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/IB2021/000464 Applicant IMMUNOVACCINE TECHNOLOGIES, INC. Inventor STANFORD, Marianne
The present application relates generally to compositions and methods for preventing COVID- 19, and in particular to vaccine compositions comprising at least one epitope on the spike protein of SARS-CoV-2 that can elicit production of antibodies, including neutralizing antibodies and antibodies that inhibit steps of viral infection (e.g., phagocytosis).
3.WO/2022/008642TREATMENT OF SARS-COV-2 INFECTION WITH A COMBINATION OF TARGETS
WO 13.01.2022
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/EP2021/068955 Applicant APEIRON BIOLOGICS AG Inventor WIRNSBERGER, Gerald
The invention provides a combination of a SARS-CoV-2 cellular entry receptor and a viral proliferation inhibitor for the treatment of a SARS-CoV-2 infection and combined pharmaceutical preparations and kit-in-parts.
4.WO/2022/008438STABILIZED CORONA VIRUS SPIKE PROTEIN FUSION PROTEINS
WO 13.01.2022
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Appl.No PCT/EP2021/068505 Applicant JANSSEN PHARMACEUTICALS, INC. Inventor LANGEDIJK, Johannes, Petrus, Maria
The present invention provides stabilized recombinant pre-fusion SARS CoV0-2 S proteins, nucleic acids molecules encoding the SARS CoV-2 S proteins and uses thereof.
5.WO/2022/011021USE OF CONSERVED PEPTIDE EPITOPES FROM SARS-COV-2 FOR THE DEVELOPMENT OF A BROAD COVID-19 VACCINE
WO 13.01.2022
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/US2021/040700 Applicant ASCENDO BIOTECHNOLOGY, INC. Inventor LU, Yen-Ta
A vaccine for generation of immunity against SARS-CoV-2 infection includes an S2'-peptide of SARS-CoV-2 in a formulation that enhances immune responses, wherein the S2'-peptide includes the amino acid sequence selected from SEQ ID NO: 1-10. The formulation includes nanocomplexes encapsulating the S2'-peptide, or the formulation includes TREM-like transcript-1 (TREML1) extracellular domain (ECD) or a stalk peptide as an immune booster.
6.20220009972METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING VIRAL INFECTION
US 13.01.2022
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 17246307 Applicant Jang Hyun HAN Inventor Jang Hyun HAN

The disclosure provides recombinant polypeptides for treating or preventing viral infection comprising an immunoglobulin Fc fragment and at least one viral receptor or fragment thereof. Also provided are RNA molecules, therapeutic compositions, and expression systems comprising such recombinant polypeptides, along with methods of preventing or treating a viral infection in a subject in need thereof, comprising administering such recombinant polypeptides to a subject or patient.

7.20220002699ACE2-Fc FUSION PROTEINS FOR SARS-COV-2 MITIGATION
US 06.01.2022
Int.Class C12N 9/48
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
Appl.No 17194282 Applicant PLANET BIOTECHNOLOGY, INC. Inventor Keith Lynn WYCOFF

The present disclosure relates to recombinant fusion proteins comprising an extracellular domain of the human angiotensin-converting enzyme 2 (ACE2), optionally having altered amino acid residues that result in increased binding affinity for the S1 spike protein of SARS-CoV-2, linked to a human immunoglobulin Fc region, that can extend the protein half-life (T1/2) and/or the duration of action as a decoy receptor, and compositions and methods of use of these fusion proteins.

8.WO/2022/000845RECOMBINANT PROTEIN VACCINE FOR PREVENTING SARS-COV-2 AND PREPARATION METHOD THEREFOR
WO 06.01.2022
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No PCT/CN2020/119701 Applicant JIANGSU PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION (PUBLIC HEALTH RESEARCH INSTITUTE OF JIANGSU PROVINCE) Inventor ZHU, Fengcai
A target amino acid sequence of a SARS-CoV-2 recombinant protein vaccine, a target gene sequence of the recombinant protein vaccine, a eukaryotic cell expression vector containing the target gene sequence, a cell expressing the target amino acid sequence, and the recombinant protein vaccine having the target amino acid sequence as an antigen. The recombinant protein vaccine can effectively induce a body to produce cellular immunity and humoral immunity, can be quickly prepared, and is suitable for the prevention of novel coronavirus.
9.WO/2022/003155A DNA PLASMID SARS-CORONAVIRUS-2/COVID-19 VACCINE
WO 06.01.2022
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Appl.No PCT/EP2021/068324 Applicant STATENS SERUM INSTITUT Inventor STRANDH, Charlotta Polacek
The present invention relates to DNA vaccine against SARS-Coronavirus-2 (SARS-CoV-2) infection. In particular, the present invention relates to a DNA vaccine encoding the SARS-Coronavirus-2 spike protein for use in prevention or treatment of viral infection in humans and/or animals. The DNA vaccine including the DNA construct has several features in its design that together provide a more safe and broad protection against SARS-CoV-2 strains in humans and animals, e.g. mink, ferrets, pigs and cats. The DNA construct encodes the SPIKE protein derived from the pandemic strain; Wuhan-Hu-1 (MN908947). The sequence is codon optimized for high expression in human and mammalian cells and the DNA construct is inserted in a selected DNA plasmid for eukaryotic in vivo and in vitro expression. The combination of the choice of SARS-CoV-2 SPIKE sequence, codon optimization, expression in the new generation eukaryotic expression plasmid with no antibiotic resistance marker (instead the RNA-OUT system is used for safety) and delivery to the very immunogenic skin, results in protection against SARS-CoV-2 infection and covid-19 disease.
10.113862286编码SARS-COV-2病毒C.37突变株抗原的DNA分子、DNA疫苗及应用
CN 31.12.2021
Int.Class C12N 15/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
40Proteins from RNA viruses, e.g. flaviviruses
50Coronaviridae, e.g. infectious bronchitis virus, transmissible gastroenteritis virus
Appl.No 202111461106.8 Applicant 艾棣维欣(苏州)生物制药有限公司 Inventor 赵干
本发明涉及生物技术领域,具体而言,提供了一种编码SARS‑COV‑2病毒C.37突变株抗原的DNA分子、DNA疫苗及应用。本发明提供的SEQ ID NO:1核酸序列在真核表达系统中能够高效转录和表达,而且具有免疫原性,表现在体液免疫和细胞免疫应答中,以此作为活性成分的核酸疫苗同样具有良好的免疫原性。