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Analysis

1.WO/2022/011752VONOPRAZAN SALT, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO 20.01.2022
Int.Class C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Appl.No PCT/CN2020/106149 Applicant HINYE PHARMACEUTICAL CO., LTD Inventor LIU, Junhua
Disclosed are a Vonoprazan salt, a preparation method therefor, and use thereof. The Vonoprazan salt of the present invention is a salt formed by Vonoprazan and a complex of an organic acid and bismuth. The present invention also covers a preparation method for the Vonoprazan salt and an application of the Vonoprazan salt in preparation of drugs for treating gastric acid diseases. Compared with existing Vonoprazan salts, the salt formed by Vonoprazan and the complex of the organic acid and bismuth of the present invention has a number of satisfactory advantages, such as good solubility and stability, increased bioavailability, and synergistically increased efficacy.
2.WO/2022/012097ANTI-HUMAN MSLN ANTIBODY AND MSLN-TARGETING IMMUNE EFFECTOR CELL
WO 20.01.2022
Int.Class C07K 16/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
Appl.No PCT/CN2021/086067 Applicant HRAIN BIOTECHNOLOGY CO., LTD. Inventor HUANG, Fei
The present invention provides an anti-human MSLN-specific antibody and an MSLN-targeting immune effector cell. Also provided is an MSLN-targeting chimeric antigen receptor modified T-cell prepared using the antibody and a use thereof.
3.WO/2022/012622DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE
WO 20.01.2022
Int.Class C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Appl.No PCT/CN2021/106482 Applicant BEIGENE, LTD. Inventor LEI, Bailin
Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.
4.WO/2022/012682CD22 BINDING MOLECULES AND USES THEREOF
WO 20.01.2022
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Appl.No PCT/CN2021/106891 Applicant NANJING LEGEND BIOTECH CO., LTD. Inventor FAN, Xiaohu
The present disclosure provides single domain antibodies that bind to CD22, and chimeric antigen receptors comprising same. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating a disease or disorder are also provided.
5.WO/2022/013027METAL-OXO CLUSTERS COMPRISING NOBLE METALS AND METAL CLUSTER UNITS THEREOF
WO 20.01.2022
Int.Class C07F 15/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
Appl.No PCT/EP2021/068765 Applicant EXXONMOBIL CHEMICAL PATENTS INC. Inventor KORTZ, Ulrich
The invention relates to noble metal-oxo clusters represented by the formula [Ms(R2XO2)z(OR')xOyX'q] or solvates thereof, corresponding supported noble metal-oxo clusters, and processes for their preparation, as well as corresponding metal cluster units, optionally in the form of a dispersion in a liquid carrier medium or immobilized on a solid support, and processes for their preparation, as well as their use in conversion of organic substrate.
6.WO/2022/013132METHOD FOR PRODUCING POLYOXYMETHYLENE DIMETHYL ETHERS
WO 20.01.2022
Int.Class C07C 41/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
41Preparation of ethers; Preparation of compounds having groups, groups or groups
01Preparation of ethers
34Separation; Purification; Stabilisation; Use of additives
40by change of physical state, e.g. by crystallisation
42by distillation
Appl.No PCT/EP2021/069282 Applicant FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V. Inventor MANTEI, Franz
The invention relates to a method for producing polyoxymethylene dimethyl ethers, having the following steps: - reacting formaldehyde and methylal (OME1) in a reactor R1, thereby obtaining a product mixture, - separating the product mixture, by means of distillation in a distillation unit D1, into a head stream, which contains OME1, OME2, formaldehyde, methanol, and water, and a sump stream, which contains OME≥3, - mixing the head stream drawn from the distillation unit D1 with a methanol-containing stream, - treating the mixture in a reactive distillation unit RD2, thereby forming a head stream, which contains methylal, and a water-containing sump stream, and - introducing the sump stream drawn from the distillation unit D1 into a distillation unit D3 and separating the polyoxymethylene dimethyl ether by means of distillation.
7.WO/2022/013312PYRIDO OXAZINE AMINO DERIVATIVES AS ALK5 INHIBITORS
WO 20.01.2022
Int.Class C07D 498/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Appl.No PCT/EP2021/069657 Applicant CHIESI FARMACEUTICI S.P.A. Inventor PALA, Daniele
The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
8.WO/2022/013417PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
WO 20.01.2022
Int.Class C07D 213/75
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Appl.No PCT/EP2021/069942 Applicant SYNGENTA CROP PROTECTION AG Inventor SIKERVAR, Vikas
Compounds of the formula (I), wherein the substituents are as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects, moluscs, nematodes or representatives of the order Acarina.
9.WO/2022/013762METHODS AND KITS FOR THE DIAGNOSIS OF LUNG CANCER
WO 20.01.2022
Int.Class G01N 33/574
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
Appl.No PCT/IB2021/056326 Applicant PINTO, Aldo Inventor PINTO, Aldo
The present invention relates to a method for the diagnosis and/or to monitor the development and/or to provide a prognosis on the development of lung cancer in an individual, including the detection of the expression levels of the isoform 4 of the human caspase-4 protein in biological samples. The present invention further relates to a kit and reagents for the detection of the expression levels of said isoform 4, as well as a compound inhibitor of said isoform 4 for use in the treatment and/or prevention of lung cancer.
10.WO/2022/014857NOVEL COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME
WO 20.01.2022
Int.Class C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
Appl.No PCT/KR2021/006773 Applicant LG CHEM, LTD. Inventor CHA, Yongbum
The present invention provides a novel compound and an organic light-emitting element comprising same.