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IC:C12P19/34

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1 / 1,685
1.WO/2024/081847APPARATUSES FOR AND METHODS OF CONCENTRATING BIOMOLECULES
WO - 18.04.2024
Int.Class B01D 61/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
 Appl.No PCT/US2023/076786 Applicant ELI LILLY AND COMPANY Inventor MASON, McKensie Lee
An apparatus is described for concentrating biomolecules in solution, such as oligonucleotide-containing solutions, via tangential flow filtration (TFF), where the apparatus can concentrate the oligonucleotides to a concentration > 100 mg/mL. Also described are methods of concentrating a biomolecule-containing solution, such as oligonucleotide-containing solutions, via TFF for high dose/low volume applications.
2.WO/2024/079270METHOD FOR SYNTHESIZING POLYNUCLEOTIDES USING A MOVE-STOP PRINTER
WO - 18.04.2024
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No PCT/EP2023/078364 Applicant DNA SCRIPT Inventor HORGAN, Adrian
Title: Method for synthesizing polynucleotides using a move-stop printer The present invention relates to a method for synthesizing polynucleotides using a move-stop printer ejecting ink droplets, comprising: a set-up step (30) during which sets of instructions are implemented, each set of instructions controlling the functioning of the move-stop printer for a row of reaction sites, each instruction of the sets of instructions controlling the opening of one nozzle; a positioning step (36); a computing step (38); a firing step (40) during which the nozzles eject droplets on at least one reaction site, according to the sets of instructions; a synthesis step (8); a moving step (47); some steps (38, 40, 8, 47) being repeated until every row of reaction sites has been placed under the nozzles of the move-stop printer.
3.2024516200環状ＲＮＡ
JP - 12.04.2024
Int.Class C12N 15/63
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
 Appl.No 2023565371 Applicant ファクター　バイオサイエンス　インコーポレイテッド Inventor エンジェル，マシュー
【課題】
改善された環状ＲＮＡ（ｃｉｒｃＲＮＡ）組成物、及びｃｉｒｃＲＮＡの作製方法が必要とされる。
【解決方法】
核酸内の実質的に相補的な領域のハイブリダイゼーション及びＲＮＡリガーゼとの接触を含み得る、環状ＲＮＡ（ｃｉｒｃＲＮＡ）の形成を促進する核酸構造。該核酸構造は、遺伝子編集応用及び／または治療応用に使用され得る。一部の実施形態では、該核酸は、構造：５’－Ｘ－Ｙ－Ａ－ＩＲＥＳ－Ｂ－ＣＤＳ－Ｃ－Ｙ’－Ｚ－３’を含み、構造中、Ｘ、Ｙ、Ｙ’、及びＺは各々独立して、１つまたは複数のヌクレオチドを含み、Ｙ及びＹ’は、実質的に相補的であり、Ｘ及びＺは、実質的に相補的ではなく、ＩＲＥＳは、配列内リボソーム進入部位を含み、ＣＤＳは、コード配列を含み、Ａ、Ｂ、及びＣは各々独立して、１つもしくは複数のヌクレオチドを含むスペーサー、またはヌルである。
【選択図】図１
4.2024516272エキソヌクレアーゼに対する増加した耐性を有する直鎖状ＤＮＡ
JP - 12.04.2024
Int.Class C40B 40/06
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
06Libraries containing nucleotides or polynucleotides, or derivatives thereof
 Appl.No 2023567068 Applicant フォーベースバイオ・ソシエダッド・リミターダ・ウニペルソナル Inventor ランクリート，ヘイッキ
本発明は、各鎖の内部位置にヌクレアーゼ耐性ヌクレオチドを含む直鎖状二本鎖ＤＮＡ産物に関する。さらに、本発明は、直鎖状二本鎖ＤＮＡ産物を含む複合体分子、ナノ粒子、組成物およびライブラリーに関する。また、直鎖状二本鎖ＤＮＡ産物の製造方法および使用方法も提供する。
【選択図】図２
5.WO/2024/074726SPECTRAL MONITORING OF IN VITRO TRANSCRIPTION
WO - 11.04.2024
Int.Class C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
 Appl.No PCT/EP2023/077921 Applicant SANOFI Inventor CLENET, Didier
The present invention provides a method for monitoring an in vitro transcription (IVT) reaction for the production of RNA within a reaction vessel. The method comprises obtaining a spectrum of a reactant or product during the IVT reaction and comparing the obtained spectrum to a pre-determined reference spectrum of the reactant or product of the IVT reaction. The method can be used to determine changes in the amount of the reactant or product during the IVT reaction.
6.2024515651選択マーカーのないプラスミドシステム及びその生産方法
JP - 10.04.2024
Int.Class C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
 Appl.No 2023563241 Applicant ナンジン、ジェンスクリプト、バイオテック、カンパニー、リミテッド Inventor ファン、チョウ
本発明は、選択マーカーのないプラスミドを製造するための前駆体プラスミドを提供し、該前駆体プラスミドは、１） 複製開始部位と、２） 選択マーカー遺伝子と、３） 標的遺伝子又は前記標的遺伝子に挿入するためのクローニング部位と、４） 対になった組換え部位とを含む。これらの対になった組換え部位により、前駆体プラスミドは、リコンビナーゼの存在下で、自己組換えを行って、娘プラスミド分子及び環状二本鎖ＤＮＡ分子を形成することができる。該娘プラスミドは、複製開始部位と、クローニング部位又は標的遺伝子とを含む。該環状二本鎖ＤＮＡは、選択マーカー遺伝子を含む。本発明は、前駆体プラスミドを用いて、選択マーカーのないプラスミドを製造する方法をさらに提供した。製造された選択マーカーのないプラスミドは、プラスミドの安全性を向上させるために、ＤＮＡ送達ベクター又はウイルスパッケージングプラスミドベクターとして、遺伝子及び細胞療法分野に用いられ得る。
【選択図】図１
7.117821460新型内含子、环状RNA及其体外制备方法
CN - 05.04.2024
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No 202410043382.X Applicant 深圳新合睿恩生物医疗科技有限公司 Inventor 王弈
本发明涉及一种环状RNA的体外制备方法，包括下列步骤：质粒构建：将T7启动子，5’同源臂，3’内含子，第二外显子E2，第一外显子E1,5’内含子，3’同源臂，和酶切位点EcoRI的基因片段连接到表达载体上；所述3’内含子和5’内含子的组成来自于SEQ ID NO.1‑SEQ ID NO.2序列；质粒线性化和纯化；体外转录；第一步环化，第二步环化，或者一步法经过纯化得到环状RNA。本发明通过将TwortⅠ型内含子进行改造，将剪切的内含子序列插入目的片段5’末端及3’末端之间，将线性的mRNA高效环化，并具有较少的外源性碱基残留，由所述制备方法得到的环状RNA可适用于mRNA疫苗的制备。
8.117821412一种dCE-KOD DNA聚合酶及其制备方法和应用
CN - 05.04.2024
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No 202311743336.2 Applicant 湖北大学 Inventor 马立新
本发明公开了一种dCE‑KOD DNA聚合酶及其制备方法和应用，所述dCE‑KOD DNA聚合酶通过在KOD DNA聚合酶蛋白序列N端融合表达大肠杆菌素CE的突变体dCE得到，其中dCE为dCE2、dCE7、dCE8和dCE9中任一。相较于天然KOD DNA聚合酶，dCE‑KOD DNA聚合酶的持续合成能力得到有效提高且对模板具有更高的敏感性，故本发明提供的dCE‑KOD DNA聚合酶在基因克隆、长片段的高保真性扩增以及PCR诊断中有着广阔的应用前景。
9.117820388一种用于mRNA合成的氘代加帽化合物及其制备方法和应用
CN - 05.04.2024
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
 Appl.No 202311550898.5 Applicant 青岛糖智医药科技有限公司 Inventor 曹学峰
本发明公开了一种用于mRNA合成的氘代加帽化合物及其制备方法和应用，涉及生物化学技术领域。氘代加帽化合物，具有如下式(I)或式(II)所示的结构：且所述氘代加帽化合物中至少含有一个氘代烷基。本发明提供的制备方法简单可复制，制备的氘代帽子类似物结构稳定，可用于检测帽子类似物的纯度，还可用于mRNA的杂质分析，另外氘代加帽化合物合成的mRNA翻译效率更高。
10.117821413一种高进行性Pfu DNA聚合酶及其制备方法和应用
CN - 05.04.2024
Int.Class C12N 9/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
 Appl.No 202311744623.5 Applicant 湖北大学 Inventor 马立新
本发明公开了一种高进行性Pfu DNA聚合酶及其制备方法和应用，所述高进行性Pfu DNA聚合酶具体为：在野生型Pfu DNA聚合酶蛋白序列N端融合表达大肠杆菌素CE的突变体dCE，其中dCE的基因序列如SEQ ID NO.2‑5任一所示。相较于野生型Pfu DNA聚合酶，改造后聚合酶的扩增速度可达到约8kb/min，远高于野生型Pfu DNA聚合酶，同时扩增产量也得到了明显提高，故本发明提供的高进行性Pfu DNA聚合酶在基因克隆、长片段的高保真性扩增以及PCR诊断中有着广阔的应用前景。
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