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Analysis

1.3169422HAIRPIN LOOP ENDED SELF-COMPLEMENTARY DOUBLE-STRANDED COVALENTLY CLOSED LINEAR DNA VECTOR, MANUFACTURING SYSTEM AND PROCESS, AND USES OF SAID RESULTING DNA VECTOR
CA 06.02.2023
Int.Class C12N 15/63
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Appl.No 3169422 Applicant WILLIAMS, MARTIN Inventor WILLIAMS, MARTIN
The present invention relates to a system and process for the production of a hairpin loop ended self-complementary double-stranded covalently closed linear deoxyribonucleic acid (DNA) vector, and the use of said vector as part of a therapeutic formulation enabling modulation of gene expression for medical applications. This system comprises a recombinant cell and at least two engineered parental circular covalently closed synthetic plasmids DNA, housed in the recombinant cell, wherein the synthetic transcriptional units of the at least two engineered parental circular covalently closed synthetic plasmids DNA are cloned in opposite directions. This DNA vector manufacturing system provides an efficient and high yield inducible process for producing hairpin loop ended linear covalently closed DNA vectors that incorporate a nucleic acid sequence of interest.
2.3138136METHOD FOR PRODUCING MAACKIAIN BY USING PLANT CELL FERMENTATION
CA 04.02.2023
Int.Class C12P 17/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
18containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Appl.No 3138136 Applicant HAINAN XINOPEN SOURCE MEDICAL TECHNOLOGY CO. LTD. Inventor CAI, XIANNENG
The present disclosure relates to the field of biotechnology, specifically to a method for inducing the production of maackiain by using suspension cells from Millettia specisoa Champ. The method comprises adding two or more selected from methyl jasmonate, phenylalanine and chitosan glutamate during the process of scale-up culture of the suspension cells from Millettia specisoa Champ. The present disclosure overcomes the shortcomings of the existing suspension culture of Millettia specisoa Champ at the shake flask level, having low cell yield, and incapable of carrying out large-scale culture. In addition, the present disclosure screens and obtains the optimal optimized medium and addition process for promoting the synthesis of the product, which greatly improves the synthesis rate of Millettia specisoa Champ maackiain, and provides a new method for the subsequent larger-scale culture of suspension cells from Millettia specisoa Champ.
3.3178008ANTI-PLA2G2D CONSTRUCTS AND USES THEREOF
CA 04.02.2023
Int.Class C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40against enzymes
Appl.No 3178008 Applicant APEXIMMUNE THERAPEUTICS INC. Inventor LEE, LI-FEN
The present application provides anti-PLA2G2D constructs that bind to PLA2G2D (e.g., anti-PLA2G2D antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-PLA2G2D, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-PLA2G2D construct, pharmaceutical compositions containing the anti-PLA2G2D construct, and methods of using the anti-PLA2G2D construct or compositions.
4.3169275METHOD OF RECOVERING NITROGEN AND SULFUR RESOURCES THROUGH ANAEROBIC FERMENTATION
CA 03.02.2023
Int.Class C12P 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
3Preparation of elements or inorganic compounds except carbon dioxide
Appl.No 3169275 Applicant SK INNOVATION CO., LTD. Inventor LA, YEON HWA
A method of preparing ammonium sulfate comprises feeding biosulfur and ammonia produced during anaerobic fermentation into a sulfur-oxidizing microbial reactor to cause sulfur-oxidizing microorganisms to produce sulfuric acid through oxidation of the biosulfur and reacting the produced sulfuric acid with ammonia to produce the ammonium sulfate, wherein a culture medium containing the produced ammonium sulfate and microorganisms can be used as fertilizers.
5.WO/2023/004969ESTERASE MUTANT AND USE THEREOF
WO 02.02.2023
Int.Class C12N 9/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
Appl.No PCT/CN2021/119423 Applicant ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. Inventor HONG, Hao
Provided are an esterase mutant and the use thereof. The esterase mutant obtained by means of rational design and several rounds of evolution screening with enzymes on the basis of an amino acid sequence as shown in SEQ ID NO: 1 is changed in terms of protein structure and functions compared with a wild-type esterase; in practical use, the catalytic activity and/or stereoselectivity of the esterase mutant is greatly improved; and when a system contains some organic cosolvents, the esterase mutant still has relatively stable catalytic activity and/or stereoselectivity. In addition, the improvement of the catalytic activity and/or stereoselectivity of the esterase mutant reduces the use amount of the enzyme to a certain extent and reduces the difficulty of post-treatment, and therefore the esterase mutant is suitable for industrial production.
6.WO/2023/005779SUCROSE SYNTHETASE AND USE THEREOF
WO 02.02.2023
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
Appl.No PCT/CN2022/106920 Applicant ABIOCHEM BIOTECHNOLOGY CO., LTD. Inventor WU, Yan
Provided are a sucrose synthetase and the use thereof. Compared with SEQ ID NO: 11, an amino acid sequence of the sucrose synthetase contains differences in amino acid residues selected from one or more of the following residue positions: an amino acid at position 36 being V, an amino acid at position 43 being E, an amino acid at position 179 being A, an amino acid at position 395 being R, an amino acid at position 447 being P, an amino acid at position 455 being L, and an amino acid at position 654 being R; and the sucrose synthetase has an activity not lower than that of a sucrose synthetase having an amino acid sequence as shown in SEQ ID NO: 11. By means of catalyzing the synthesis of rebaudioside A, rebaudioside D or rebaudioside M by using a glucosyltransferase and the sucrose synthetase in a combined manner, a cascade reaction is achieved, thereby providing a variety of possibilities for the selection of raw materials.
7.WO/2023/006109HIGHLY SPECIFIC GLYCOSYLTRANSFERASE FOR RHAMNOSE, AND USE THEREOF
WO 02.02.2023
Int.Class C12N 9/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
Appl.No PCT/CN2022/109355 Applicant SYNBIOTECH (SUZHOU) CO., LTD. Inventor YAN, Xing
Provided in the present invention are a highly specific glycosyltransferase for rhamnose, and the use thereof. A specific glycosyltransferase is disclosed in the present invention for the first time, which glycosyltransferase can catalyze rhamnosylation at a specific position of a substrate, and has high catalytic activity. Specifically, the specific glycosyltransferase of the present invention can specifically and efficiently catalyze the glycosylation of the C-6 position of a tetracyclic triterpene compound substrate on a first glycosyl so as to extend a rhamnose group. Also provided in the present invention is a mutant of the specific glycosyltransferase. The specific glycosyltransferase of the present invention has good specificity and high efficiency, can be applied to the construction of artificially synthesized ginsenoside, various new ginsenosides and derivatives thereof, and has good application value in the fields of pharmacy, etc.
8.20230034185DISEASE RESISTANCE LOCI IN ONION
US 02.02.2023
Int.Class A01H 1/04
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
HNEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
1Processes for modifying genotypes
04Processes of selection
Appl.No 17855475 Applicant Seminis Vegetable Seeds, Inc. Inventor Lowell Black

The present disclosure provides for unique onion plants with disease resistance and desirable bulb color and their progeny. Such plants may comprise an introgressed QTL associated with multiple disease resistance coupled with a desirable bulb color. In certain aspects, compositions, including distinct polymorphic molecular markers, and methods for producing, breeding, identifying, selecting, and the like of plants or germplasm with disease resistance and/or desirable bulb color are provided.

9.20230036629METHODS FOR INHIBITING GROWTH OF ORAL PATHOGENIC BACTERIA AND ALLEVIATING ORAL PATHOGENIC BACTERIA-ASSOCIATED DISORDER
US 02.02.2023
Int.Class A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
Appl.No 17573049 Applicant GLAC BIOTECH CO., LTD. Inventor Hsieh-Hsun Ho

Disclosed herein are methods for inhibiting growth of oral pathogenic bacteria and alleviating an oral pathogenic bacteria-associated disorder using a culture of at least one lactic acid bacterial strain selected from the group consisting of Lactobacillus rhamnosus MP108 which is deposited at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 21225, and Lactobacillus paracasei MP137 which is deposited at the CGMCC under an accession number CGMCC 21224.

10.20230029594BODY FAT REDUCING AGENT AND METHOD FOR SCREENING FOR SUBSTANCE CAPABLE OF REDUCING BODY FAT
US 02.02.2023
Int.Class C12Q 1/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
Appl.No 17788524 Applicant OSAKA UNIVERSITY Inventor Shizuo AKIRA

The present invention provides a body fat reducing agent comprising a Regnase-1 inhibitor as an active ingredient, and a method for screening for a substance capable of reducing body fat, the method comprising selecting a substance capable of inhibiting the expression of Regnase-1 or a substance capable of inhibiting the function of Regnase-1. The body fat reducing agent of the present invention is useful for improving metabolic syndrome, and for preventing and/or treating fatty liver disease, including nonalcoholic steatohepatitis (NASH). The screening method of the present invention can be used to identify a useful substance capable of reducing body fat.