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Analysis

1 / 3,574
1.WO/2025/138441BIOLOGICAL REACTION SYSTEM
WO - 03.07.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/CN2024/080616 Applicant BMF NANO MATERIAL TECHNOLOGY CO., LTD Inventor YANG, Chen
Disclosed is a biological reaction system. The biological reaction system comprises: a micro-fluidic chip, a fixture, and an infusion device. The fixture comprises: a fixture body and a fixing assembly, a first surface of the fixture body being provided with an accommodation slot, a second surface of the fixture body being opposite to the first surface, and the accommodation slot being used for placing the micro-fluidic chip. The fixture body is further provided with a liquid injection channel and a liquid extraction channel, a first end of the liquid injection channel being used for delivering a liquid to the micro-fluidic chip, the liquid discharged from the micro-fluidic chip flowing into the accommodation slot, and the accommodation slot being communicated with a first end of the liquid extraction channel. The fixing assembly is provided on the fixture body and is used for fixing the micro-fluidic chip in the accommodation slot. The infusion device is separately connected to a second end of the liquid injection channel and a second end of the liquid extraction channel, and is used for replacing the liquid in the micro-fluidic chip.
2.WO/2025/143067CELL CULTURE CONTAINER AND CELL CULTURE METHOD USING SAME
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2024/046036 Applicant MIYAKAWA, Hiroyuki Inventor MIYAKAWA, Hiroyuki
Provided is a cell culture container that ensures a broad cell adhesion surface for adhesion and proliferation of cells inside the container. This cell culture container comprises a bottomed container body 1 that has a polygonal, columnar internal space, a polygonal, columnar first cylindrical body 2 that is provided inside the container body 1 so as to be coaxial with the container body 1, a lid body 4 that is attached to an axial end part of the container body, a cap 5 that is attached to a cylindrical neck part of the lid body 4, and first spacers 21, 22 that are corner parts of an outer circumferential surface of the first cylindrical body 2 at an axial end part of the first cylindrical body 2. The first spacers 21, 22 are fitted into corner parts of an inner circumferential surface of the container body 1.
3.WO/2025/145121FUNCTIONALLY CLOSED CELL PROCESSING SYSTEM
WO - 03.07.2025
Int.Class B04B 13/00
BPERFORMING OPERATIONS; TRANSPORTING
04CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
BCENTRIFUGES
13Control arrangements specially designed for centrifuges; Programme control of centrifuges
 Appl.No PCT/US2024/062192 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor COELHO, Philip, H.
A functionally closed cell processing platform designed to minimize contamination and automate cell processing. The platform integrates multiple specialized cassettes, including a reagent sample cassette (RSC) for reagent delivery and sample collection, a process fluids cassette (PFC) for waste and buffer management, and a cell processing cassette (CPC) for cell handling, along with a transfer syringe cassette (TSC) for precise fluid transfer. The system features a centrifuge capable of multi-mode operation for cell concentration and mixing, pneumatic controls for fluid and microbubble manipulation, and UV sanitizers to maintain aseptic conditions. Advanced functionalities include optical and thermal sensors for real-time monitoring, automated control of fluid and reagent handling, and a microbubble cell selection system for precise target cell isolation. This innovative platform ensures efficient, contamination-free cell processing, supporting applications in gene therapy, cell manufacturing, and biomedical research.
4.WO/2025/140874MIXING DEVICE FOR A BIOLOGICAL LIQUID, MIXING SYSTEM FOR A BIOLOGICAL LIQUID, AND METHOD FOR OPERATING A MIXING DEVICE FOR A BIOLOGICAL LIQUID
WO - 03.07.2025
Int.Class B01F 31/31
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
31Mixers with shaking, oscillating, or vibrating mechanisms
30comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
31using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
 Appl.No PCT/EP2024/086325 Applicant CYTIVA SWEDEN AB Inventor LUNDKVIST, Mats
A mixing device (14) for a biological liquid is described. The mixing device (14) comprises a mixing chamber (38) delimited by a first flexible wall segment (20) and by a second flexible wall segment (30), wherein the first flexible wall segment (20) and the second flexible wall segment (30) are arranged on different sides of the mixing chamber (38). The first flexible wall segment (20) comprises a first actuator interface (26) configured to couple a first actuator to the first flexible wall segment (20) such that the first flexible wall segment (20) is displaceable by operating the first actuator. The second flexible wall segment (30) comprises a second actuator interface (36) configured to couple a second actuator to the second flexible wall segment (30) such that the second flexible wall segment (30) is displaceable by operating the second actuator. Additionally, a mixing system for a biological liquid is shown. The mixing system comprises such a mixing device (14), wherein a first actuator is coupled to the first actuator interface (26) and a second actuator is coupled to the second actuator interface (36). Moreover, a method for operating a mixing device (14) for a biological liquid is presented.
5.WO/2025/145028CORNEAL ENDOTHELIAL CELL COMPOSITIONS AND DELIVERY METHODS THEREOF
WO - 03.07.2025
Int.Class A61K 35/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
 Appl.No PCT/US2024/062087 Applicant AURION BIOTECH, INC. Inventor LACOSTE, Arnaud
Provided are compositions comprising aggregates of corneal endothelial cells (CECs) and methods administering said aggregates to patients for the treatment of corneal endothelial disease.
6.WO/2025/145118OPTIMIZED GEOMETRIC DESIGN OF A CELL PROCESSING CASSETTE
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/US2024/062189 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor COELHO, Philip H.
The disclosed invention presents the AutoCell Platform (ACP), an advanced, fully automated, and functionally closed system designed to revolutionize the manufacturing of gene-modified cell therapies. This innovative platform integrates automation, closed-loop processing, and novel technologies to address the inefficiencies and high costs of conventional methods. Key features include automated spinoculation for enhanced genetic modification efficiency, microbubble-assisted cell selection for precise cell isolation, and modular design for scalability across clinical and research settings. By reducing production timelines from 30-40 days to under 3 days and lowering costs by an order of magnitude, the ACP enables point-of-care manufacturing, decentralization, and broader accessibility. Advanced quality control measures and a standardized design ensure regulatory compliance and consistent therapeutic outcomes. The ACP supports diverse applications, from CAR-T therapies to regenerative medicine, representing a transformative leap in precision medicine and the global accessibility of life-saving cell-based therapies.
7.WO/2025/142643RECOVERY SYSTEM, CELL CULTURE SYSTEM, AND RECOVERY METHOD
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2024/044620 Applicant MITSUBISHI HEAVY INDUSTRIES, LTD. Inventor MATSUZAWA Takashi
A recovery system according to the present disclosure comprises: a wall that extends in the horizontal direction, partitions a clean space and an external space, and has a discharge port formed to penetrate therethrough in the up-down direction, the external space being located below the clean space and having a negative pressure with respect to the clean space; and a recovery device that is provided in the external space below the wall and recovers, from the clean space, a workpiece capable of containing a culture solution. The recovery device includes: an elevator having a platform on which the workpiece can be placed and that is movable in the up-down direction from the discharge port to a predetermined height in the external space; and a shelf that is positioned side by side with the elevator in a horizontal first direction and can store the workpiece placed on the platform. The platform is provided so that the platform can be positioned in the discharge port with a predetermined gap from the discharge port.
8.WO/2025/142778WORKPIECE PEDESTAL PLATE, WORKPIECE, AND CELL CULTURE SYSTEM
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2024/045185 Applicant MITSUBISHI HEAVY INDUSTRIES, LTD. Inventor KOMATSU Hirone
This workpiece pedestal plate is attachable to and detachable from an upper surface of a tray of a heat sealer, and is for placing thereon a workpiece that is heat-sealed by the heat sealer. The workpiece pedestal plate comprises: a placement part that has a support surface for supporting the workpiece from below; a base part that can be placed on the upper surface of the tray; a positioning part that performs positioning with respect to the tray; and a supported part that is positioned above the base part and can be supported by a conveyance device from below.
9.WO/2025/141425A BIOPRINTED LIVER MODEL, A METHOD FOR MANUFACTURING THE LIVER MODEL AND THE USE THEREOF IN CYTOTOXICITY EVALUATION
WO - 03.07.2025
Int.Class B33Y 10/00
BPERFORMING OPERATIONS; TRANSPORTING
33ADDITIVE MANUFACTURING TECHNOLOGY
YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
10Processes of additive manufacturing
 Appl.No PCT/IB2024/062960 Applicant POLBIONICA SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA Inventor DOBRZANSKI, Tomasz
A bioprinted liver model with a vascular system consisting of layers and comprising at least one flow channel in which: the first two layers forming the base of the model are 100% filled with bioink, and wherein layer 1 is positioned at an angle of 0° to the flow channel and layer 2 is positioned at an angle of 90° to the flow channel, the inner layers of the model are filled from 20% to 100% with bioink, wherein the inner layers comprise a centrally located at least one flow channel, the perimeter of which is printed with 100% filling and in which every inner layer is arranged at an angle of 60° with respect to the previous layer, the last two layers enclosing the model: the penultimate and the last layer are 100% filled with bioink and wherein the penultimate layer is arranged at an angle of 0° with respect to the flow channel and the last layer is arranged at an angle of 90° with respect to the flow channel, wherein the bioink used is based on natural polymers, synthetic polymers, methacrylated derivatives of natural polymers or mixtures thereof. A method for manufacturing the liver model and the use thereof.
10.WO/2025/144364INCUBATOR INTEGRATED ELECTROCHEMICAL ANALYSIS PLATFORM
WO - 03.07.2025
Int.Class C12M 1/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
 Appl.No PCT/TR2024/051817 Applicant IZMIR BIYOTIP VE GENOM MERKEZI Inventor CETIN, Arif Engin
The invention relates to an electrochemical analysis method and platform compatible with screen-printed electrodes (SPE) (27) and any potentiostat (2) designed for cell-based tests, enabling cells to maintain healthy proliferation while being shielded from external influences.
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