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Analysis

1 / 12,585
1.WO/2025/140587CYCLIC DINUCLEOTIDE COMPOUND, CONJUGATE THEREOF, AND USE THEREOF
WO - 03.07.2025
Int.Class A61K 47/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
 Appl.No PCT/CN2024/143264 Applicant SHANGHAI DE NOVO PHARMATECH CO., LTD. Inventor ZHANG, Wei
Disclosed in the present invention are a cyclic dinucleotide compound, a conjugate thereof, and use thereof, and particularly disclosed is an antibody-immunostimulant conjugate represented by formula II or a pharmaceutically acceptable salt thereof. The antibody-immunostimulant conjugate provided by the present invention has good tumor specificity and exhibits a significant inhibition effect on tumors.
2.WO/2025/140632TARGETING COMPOUND FOR USE IN DELIVERY AND USE THEREOF
WO - 03.07.2025
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
 Appl.No PCT/CN2024/143392 Applicant WUHAN HUMANWELL INNOVATIVE DRUG RESEARCH AND DEVELOPMENT CENTER LIMITED COMPANY Inventor ZHANG, Xuejun
Disclosed in the present invention is a compound represented by formula (I) or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof.
3.WO/2025/142857SALT OF REDUCED β-NICOTINAMIDE MONONUCLEOTIDE, AND METHOD FOR PRODUCING SAME
WO - 03.07.2025
Int.Class C07H 19/048
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
048Pyridine radicals
 Appl.No PCT/JP2024/045513 Applicant KANEKA CORPORATION Inventor YOSHIDA, Masashi
The purposes of the present disclosure are: to provide a novel salt of reduced β-nicotinamide mononucleotide (NMNH), the NMNH being expected to have an excellent anti-aging effect and the salt being easy to distribute and handle; and to provide a method for producing the novel salt of NMNH.　One embodiment of the present invention is a salt of reduced β-nicotinamide mononucleotide that is at least one salt selected from among potassium salts, ammonium salts, and divalent metal salts excluding calcium salts.
4.WO/2025/143262DOUBLE-STRANDED RNA CONTAINING CARBAMOYLETHYL MODIFICATION
WO - 03.07.2025
Int.Class C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
 Appl.No PCT/JP2024/046495 Applicant NISSAN CHEMICAL CORPORATION Inventor IRIYAMA Yusuke
The purpose of the present invention is to provide a chemically modified siRNA having further enhanced metabolic stability while maintaining activity.　The present invention provides a double-stranded RNA capable of inhibiting expression of a target RNA, wherein the double-stranded RNA contains a sense strand and an antisense strand, the antisense strand has 14-40 nucleotides and has sufficient complementarity with the target RNA to mediate RNA interference, the sense strand has 14-40 nucleotides and has complementarity with the antisense strand, and the double-stranded RNA contains at least one 2'-O-XCE nucleotide.
5.WO/2025/141521LIPIDS HAVING DENDRITIC MOIETIES
WO - 03.07.2025
Int.Class A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
 Appl.No PCT/IB2024/063236 Applicant SANOFI Inventor BAZIN, Emilie
Provided herein are dendritic lipids or pharmaceutically acceptable salts thereof. The dendritic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
6.WO/2025/139811NUCLEIC ACID CONJUGATE, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO - 03.07.2025
Int.Class C07H 15/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
26Acyclic or carbocyclic radicals, substituted by hetero rings
 Appl.No PCT/CN2024/138707 Applicant SUZHOU SIRAN BIOTECHNOLOGY CO., LTD. Inventor YANG, Zhiwei
The present invention relates to a compound for forming a conjugate with an oligonucleotide, the compound having a structure as represented by formula (I). Also provided in the present invention are a corresponding conjugate, and the use of the conjugate in preparing a drug for treating and/or preventing hepatogenic diseases. The delivery molecule disclosed in the present invention uses a saturated cyclic group and a novel linker to serve as a core skeleton to link to a phosphodiester bond, and compared with the prior art, exhibits excellent animal in-vivo bioactivity and long-acting drug efficacy, and also achieves the advantages of cheap raw materials, simple synthesis, feasible process development, good oligonucleotide synthesis efficiency, etc. In addition, the present invention improves the linker between galactosamine and the phosphodiester bond, thereby improving the metabolic stability of the whole delivery molecule and further improving the in-vivo delivery efficiency.
7.WO/2025/142856CALCIUM SALT OF REDUCED Β-NICOTINAMIDE MONONUCLEOTIDE AND METHOD FOR PRODUCING SAME
WO - 03.07.2025
Int.Class C07H 19/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
 Appl.No PCT/JP2024/045512 Applicant KANEKA CORPORATION Inventor MATSUBARA, Hisanori
The purpose of the present disclosure is to provide, with regard to reduced β-nicotinamide mononucleotide (NMNH), which is expected to exhibit an excellent anti-aging effect, a calcium salt of NMNH as a novel NMNH salt that is easy to distribute and handle and provide a method for producing the calcium salt of NMNH.　One aspect of the present embodiment is a calcium salt of reduced β-nicotinamide mononucleotide.
8.WO/2025/144716NUCLEOTIDES WITH ENZYMATICALLY CLEAVABLE 3'-O-GLYCOSIDE BLOCKING GROUPS FOR SEQUENCING
WO - 03.07.2025
Int.Class C07H 19/067
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
067with ribosyl as the saccharide radical
 Appl.No PCT/US2024/061310 Applicant ILLUMINA, INC. Inventor EMOND, Stephane
Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with 3'-O-glycoside blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and methods and kits for sequencing applications.
9.WO/2025/141025NOVEL CAPPING STRATEGIES FOR MRNA 5'CAP
WO - 03.07.2025
Int.Class C07H 19/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
 Appl.No PCT/EP2024/088312 Applicant ELEVEN THERAPEUTICS LTD Inventor DELABARRE, Byron Scott
The present invention relates to synthetic cap analogs useful for the functionalization of mRNAs, which can replace canonical cap structures. Compounds disclosed herein may be functionalized with a polynucleotide using chemical synthesis approaches.
10.WO/2025/138610SYNTHESIS PROCESS FOR OLIGONUCLEOTIDE PRIMER
WO - 03.07.2025
Int.Class C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
 Appl.No PCT/CN2024/098367 Applicant GENERAL BIOL (ANHUI) CO., LTD. Inventor LIU, Zongwen
The present invention belongs to the technical field of nucleic acid synthesis. Disclosed is a synthesis process for an oligonucleotide primer. The synthesis process comprises the following steps: step 1, adding dried chloromethylated polystyrene resin to toluene, after swelling, adding p-diaminoazobenzene, and performing a reaction at 70℃ under stirring, so as to obtain microspheres; and loading a protection group on the surface of the microspheres to obtain a solid-phase support; step 2, synthesizing a primer: completing the synthesis of the primer on the solid-phase support, so as to obtain a primer crude product, and performing an ammonolysis reaction: putting the solid-phase support containing the primer crude product into an ammonolysis solution and performing ammonolysis, the ammonolysis being carried out alternately under ultraviolet light and visible light; and step 3, purifying the primer.
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