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Analysis

1 / 21
1.WO/2024/081849POST-SYNTHETIC MODIFICATION OF POLYNUCLEOTIDES VIA ACYLATION REAGENTS
WO - 18.04.2024
Int.Class C07H 21/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02with ribosyl as saccharide radical
 Appl.No PCT/US2023/076789 Applicant CARNEGIE MELLON UNIVERSITY Inventor MATYJASZEWSKI, Krzysztof
A method of modifying a polynucleotide includes reacting the polynucleotide with one or more molecules of an acylating reagent. The acylating reagent includes an acylating compound conjugated to (i) an initiator compound for reversible deactivation radical polymerization; (ii) a chain transfer agent for reversible deactivation radical polymerization or (iii) a compound comprising a polymerizable group to form a modified polynucleotide.
2.WO/2024/081851PHOSPHORAMIDITE CONJUGATES AND METHODS OF FORMING SYNTHETIC OLIGONUCLEOTIDES THEREFROM
WO - 18.04.2024
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No PCT/US2023/076793 Applicant CARNEGIE MELLON UNIVERSITY Inventor MATYJASZEWSKI, Krzysztof
A method of synthesizing a polynucleotide composition includes performing a synthesis of the polynucleotide composition via phosphoramidite chemistry, solid-phase supported synthesis, to create polynucleotide chain. During at least one cycle of the synthesis, coupling an RDRP-phophoramidite reagent in a growing chain of the polynucleotide composition. The RDRP -phophoramidite reagent, includes a phosphoramidite compound conjugated to an RDRP initiator or a chain transfer agent for RDRP via a moiety comprising a protected hydroxyl group. A hydroxyl protecting group of the protected hydroxyl group is stable to polynucleotide synthesis conditions.
3.20230309554Polymer Carriers for Delivery of Agrochemicals in Crop Plants
US - 05.10.2023
Int.Class A01N 25/10
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
08containing solids as carriers or diluents
10Macromolecular compounds
 Appl.No 18012048 Applicant Carnegie Mellon University Inventor Gregory Lowry

Polymeric nanoparticles are provided for use in delivery of cargoes to plants. A method of delivering cargoes to plants, and to particular plant parts is provided. A method of treating heat stress in a plant also is provided.

4.20230079313Enzyme-assisted ATRP procedures
US - 16.03.2023
Int.Class C08F 4/10
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
4Polymerisation catalysts
06Metallic compounds other than hydrides and other than metallo-organic compounds; Boron halide or aluminium halide complexes with organic compounds containing oxygen
10of alkaline earth metals, zinc, cadmium, mercury, copper, or silver
 Appl.No 17942952 Applicant Carnegie Mellon University Inventor Krzysztof Matyjaszewski

Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.

5.20230049990Aqueous route to nitrogen-doped mesoporous carbons
US - 16.02.2023
Int.Class C01B 32/348
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
32Carbon; Compounds thereof
30Active carbon
312Preparation
342characterised by non-gaseous activating agents
348Metallic compounds
 Appl.No 17959913 Applicant CARNEGIE MELLON UNIVERSITY Inventor Krzysztof Matyjaszewski

A method for preparation of mesoporous nitrogen-doped carbon includes forming a composition by solubilizing a nitrogen-containing polymer in an aqueous solution of ZnCl2 and drying the aqueous solution, the method further includes heating the composition after drying to a temperature sufficiently high to carbonize the nitrogen-containing polymer to form the mesoporous nitrogen-doped carbon.

6.20220145291Extracellular Vesicle Functionalization Using Oligonucleotide Tethers
US - 12.05.2022
Int.Class C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
 Appl.No 17430837 Applicant Carnegie Mellon University Inventor Subha Ranjan Das

Provided herein are tethered extracellular vesicles and methods of making tethered extracellular vesicles.

7.20220077460ELECTRODE COMPOSITIONS AND SYSTEMS FOR BATTERIES
US - 10.03.2022
Int.Class H01M 4/38
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
MPROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
4Electrodes
02Electrodes composed of, or comprising, active material
36Selection of substances as active materials, active masses, active liquids
38of elements or alloys
 Appl.No 17414742 Applicant CARNEGIE MELLON UNIVERSITY Inventor Krzysztof Matyjaszewski

A process for the formation of a deformable battery electrode includes mixing a metal component including at least one of a metal or a metal alloy, a polymer component, and a dispersant component to create a mixture. The method further includes heated the mixture to a temperature above the melting point of the metal or the metal alloy and agitating the mixture to form a dispersion of the (molten) metal or the metal alloy in the mixture. The method further includes cooling the mixture to a temperature below the melting point of the metal or the metal alloy to form a stabilized dispersion of the metal or the metal alloy. The polymer component includes a polymer having a melting point equal to or below that of the metal or the metal alloy and a glass transition temperature sufficiently low that the stabilized dispersion is deformable.

8.WO/2021/262697POLYMER CARRIERS FOR DELIVERY OF AGROCHEMICALS IN CROP PLANTS
WO - 30.12.2021
Int.Class C08F 220/06
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
220Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide, or nitrile thereof
02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
04Acids; Metals salts or ammonium salts thereof
06Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
 Appl.No PCT/US2021/038449 Applicant CARNEGIE MELLON UNIVERSITY Inventor LOWRY, Gregory
Polymeric nanoparticles are provided for use in delivery of cargoes to plants. A method of delivering cargoes to plants, and to particular plant parts is provided. A method of treating heat stress in a plant also is provided.
9.20210309783SYNTHESIS OF POLYMER UNDER CONDITIONS OF ENHANCED CATALYZED RADICAL TERMINATION
US - 07.10.2021
Int.Class C08F 293/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
293Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
 Appl.No 17059806 Applicant CARNEGIE MELLON UNIVERSITY Inventor Krzysztof MATYJASZEWSKI

A method of carrying out an atom transfer radical polymerization wherein intermolecular crosslinking can occur includes controlling an amount of crosslinking by carrying out the reaction under conditions wherein catalytic radical termination is favored over radical termination.

10.20210290769TAILORING SITE SPECIFICITY OF BIOCONJUGATION USING STEP-WISE ATRP ON PROTEINS
US - 23.09.2021
Int.Class A61K 47/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
58obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyacrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
 Appl.No 17264519 Applicant Carnegie Mellon University Inventor Alan J. Russell

Materials and methods for targeted and controlled addition of polymers to proteins are provided herein. For example, the methods provided herein can include contacting a protein with (i) an inactive controlled radical polymerization (CRP) initiator blocker that can reacts with amino groups on the protein but cannot serve as an initiator for polymer addition, and (ii) an active CRP initiator that reacts with amino groups on the protein and also includes a group through which a polymer can be coupled to the initiator.

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