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IC:A61K39/12

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1 / 3,026
1.WO/2024/092025CONSTRUCTS AND THEIR USE
WO - 02.05.2024
Int.Class A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
 Appl.No PCT/US2023/077759 Applicant NYKODE THERAPEUTICS ASA Inventor HEIM, Joel Benjamin
The present invention relates to constructs, i.e. multimeric proteins, polypeptides and polynucleotides encoding same, to methods for preparing such constructs, to pharmaceutical compositions comprising the constructs, and to the use of such pharmaceutical compositions in the treatment or prevention of diseases
2.WO/2024/091921STABILIZATION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) ENVELOPES
WO - 02.05.2024
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2023/077611 Applicant DUKE UNIVERSITY Inventor WRAPP, Daniel
Disclosed are stabilized type I fusion proteins (e.g., HIV envelope proteins). For HIV-1, the stabilization of Env due to the disclosed modications are compatible and, in some embodiments, synergistic with stabilization mutations known as SOS, IP and SOSIP. The disclosed stabilized Env proteins retain the antigenicity of the unmodified protein.
3.WO/2024/091990METHODS OF TREATMENT OF HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (HSIL)
WO - 02.05.2024
Int.Class A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
 Appl.No PCT/US2023/077707 Applicant INOVIO PHARMACEUTICALS, INC. Inventor MORROW, Matthew P.
Described are methods of treating human papillomavirus (HPV) type 16- or HPV type 18-related High-grade Squamous Intraepithelial Lesion (HSIL) of the cervix. The described methods comprise evaluating one or more biological samples for the presence of miRNAs and isomiRs thereof.
4.WO/2024/091976COMPOSITIONS COMPRISING HIV-1 MEMBRANE PROXIMAL EXTERNAL REGION (MPER) PEPTIDES AND NUCLEIC ACIDS ENCODING MPER PEPTIDES
WO - 02.05.2024
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2023/077686 Applicant DUKE UNIVERSITY Inventor KORBER, Bette, T.
In certain aspects the invention provides HIV-1 immunogens, including one or more HIV-1 MPER peptides or HIV-1 envelope protein sequence comprising a MPER peptide for antibody induction.
5.WO/2024/091961SYSTEMS, METHODS, AND COMPUTER READABLE MEDIUM FOR DYNAMICALLY ANALYZING AND/OR MODIFYING BLOCKCHAIN NETWORKS
WO - 02.05.2024
Int.Class C07K 14/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16HIV-1
 Appl.No PCT/US2023/077667 Applicant EDGEVANA, INC. Inventor FAY, Ryan
A methodology to determine the level of decentralization for systems that use distributed ledger technologies - including but not limited to blockchains - that comprise an overall measure of decentralization created by summing multiple measures that are calculated using the Gini Coefficient and weighted using predetermined criteria, which correspond to levels of decentralization based on various criteria for the miners or validators that make up the distributed ledger system.
6.WO/2024/091962COMPOSITIONS COMPRISING ENGINEERED ENVELOPES TO ENGAGE CD4 BINDING SITE BROADLY NEUTRALIZING ANTIBODY PRECURSORS
WO - 02.05.2024
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2023/077669 Applicant DUKE UNIVERSITY Inventor COUNTS, James
In certain aspects the invention provides HIV-1 immunogens, including HIV-1 envelopes with an optimized D loop, V5 loop, and/or CD4 binding loop for antibody induction.
7.WO/2024/091258ADJUVANTED SUBCUTANEOUSLY-ADMINISTERED POLYPEPTIDE SARS- COV-2 VACCINES COMPOSITION AND METHODS
WO - 02.05.2024
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
 Appl.No PCT/US2022/049375 Applicant D4 LABS, LLC Inventor BOWE, Michael
Disclosed herein are subcutaneously administered, immunogenic compositions (e.g., vaccines) and methods of using and preparing the same. In some embodiments, the immunogenic compositions generate IgG antibodies to the spike proteins of the Wuhan-Hu- 1, Delta B.1.617.2, and Omicron BA. l variants of SARS-CoV-2 and may be suitable for use in preventing an infectious disease, such as SARS-CoV-2.
8.WO/2024/089638NUCLEIC ACID BASED VACCINE
WO - 02.05.2024
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
 Appl.No PCT/IB2023/060807 Applicant GLAXOSMITHKLINE BIOLOGICALS SA Inventor PETSCH, Benjamin
The present invention is directed to nucleic acids suitable for use in treatment or prophylaxis of an infection with a coronavirus, such as a Coronavirus SARS-CoV-2 variant, or a disorder related to such an infection, such as COVID-19. The present invention is also directed to compositions, and vaccines. The compositions and vaccines comprise at least one of said nucleic acid sequences, and nucleic acid sequences in association with a lipid nanoparticle (LNP). The invention is also directed to first and second medical uses of the nucleic acids, the composition, the vaccine, and the kit, and to methods of treating or preventing a coronavirus infection, such as a Coronavirus infection from a SARS-CoV-2 variant.
9.WO/2024/091968COMPOSITIONS COMPRISING MRNAS ENCODING HIV-1 MEMBRANE PROXIMAL EXTERNAL REGION (MPER) PEPTIDES
WO - 02.05.2024
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2023/077677 Applicant DUKE UNIVERSITY Inventor KORBER, Bette, T.
In certain aspects the invention provides HIV-1 immunogens, including one or more HIV-1 MPER peptides or HIV-1 envelope protein sequence comprising a MPER peptide for antibody induction. In some embodiments, the one or more HIV-1 MPER peptides or HIV-1 envelope protein sequence comprising a MPER peptide are encoded by mRNAs.
10.WO/2024/092058COMPOSITIONS COMPRISING HIV-1 ENVELOPES WITH ENGINEERED V1V2 OR MRNAS ENCODING THE SAME FOR BROAD V3-GLYCAN NEUTRALIZING ANTIBODY BINDING
WO - 02.05.2024
Int.Class C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
 Appl.No PCT/US2023/077804 Applicant DUKE UNIVERSITY Inventor SAUNDERS, Kevin, O.
The invention is directed to modified HIV-1 envelopes, compositions comprising these modified envelopes, nucleic acids encoding these modified envelopes, compositions comprising these nucleic acids, and methods of using these modified HIV-1 envelopes and/or these nucleic acids to induce immune responses.
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