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IC_EX:G16B* AND EN_ALLTXT:(coronavirus OR coronaviruses OR coronaviridae OR coronavirinae OR orthocoronavirus OR orthocoronaviruses OR orthocoronaviridae OR orthocoronavirinae OR betacoronavirus OR betacoronaviruses OR betacoronaviridae OR betacoronavirinae OR sarbecovirus OR sarbecoviruses OR sarbecoviridae OR sarbecovirinae OR "severe acute respiratory syndrome" OR sars OR "2019 ncov" OR covid)

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Analysis

1.3892298EPITOPES HAVING SEQUENCE HOMOLOGY TO CORONAVIRUS SPIKE PROTEIN SUBUNIT AND USES THEREOF
EP 13.10.2021
Int.Class A61K 39/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 20169101 Applicant PREVIPHARMA CONSULTING GMBH Inventor KIESSIG STEPHAN T
The present invention relates to polypeptides comprising epitopes having a sequence homology to a sequence section of subunit S1 and/or subunit S2 of coronavirus spike protein from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the present invention refers to a vaccine comprising such polypeptide. The invention further relates to an antibody binding to subunit S1 and/or subunit S2 and to methods for isolating and detecting such antibody and to uses of the polypeptides and antibodies.
2.WO/2021/096980METHODS AND SYSTEMS FOR IDENTIFYING, CLASSIFYING, AND/OR RANKING GENETIC SEQUENCES
WO 20.05.2021
Int.Class G16B 10/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
10ICT specially adapted for evolutionary bioinformatics, e.g. phylogenetic tree construction or analysis
Appl.No PCT/US2020/060045 Applicant REGENERON PHARMACEUTICALS, INC. Inventor COPIN, Richard
The present disclosure provides methods and systems for analysis of genomic sequence information. The present disclosure provides, among other things, methods and systems for characterizing sequence conservation. As is discussed herein, certain methods and systems of the present disclosure include assignment of a similarity score to a sequence or pairwise sequence comparison based on a measure of coverage and a measure of identity between two aligned sequences.
3.202131015870HAMAMELITANNIN AND ROSMARINIC ACID AS COVID-19 INHIBITORS
IN 07.05.2021
Int.Class C07D /
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
Appl.No 202131015870 Applicant Rajesh Kumar Das Inventor Rajesh Kumar Das
The present invention relates to identifying and screening best phytochemicals as potent inhibitors against COVID-19as it was recently, caused the outbreak situation of global public health. For this research we choose two standard drugs namely hamamelitannin and rosmarinic acid as a probable inhibitor of pandemic COVID-19 receptor as compared to antimalarial drug hydroxychloroquine, anti-viral drug remdesivir and also baricitinib. This study was done by taking into consideration of molecular docking study, performed with Auto Dock 4.0 (AD4.0). The results shown protein-ligand interaction of hamamelitannin and rosmarinic acid showing comparable binding energies than that of clinically applying probable COVID-19 inhibitors hydroxychloroquine (an anti-malarial drug) and remdesivir (an anti-viral drug).
4.202111002831“DISCOVEY OF IMATINIB A DRUG FOR TREATING CORONAVIRIDAE FAMILY OF VIRUS”
IN 12.02.2021
Int.Class G16C /
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
Appl.No 202111002831 Applicant Dr. Vishal M. Balaramnavar Inventor Dr. Vishal M. Balaramnavar
A method (300) for identifying a binding site of an Imatinib drug, the method comprising:developing pharmacophore models to extract features from the Imatinib drug;validating the developed pharmacophore models by comparing with pre-defined models of existing coronavirus drugs;performing a ligand-based virtual screening (first virtual screening) of a database of drugs with the validated pharmacophore models; performing a structure-based virtual screening (second virtual screening) of the validated pharmacophore models by structural docking of a target protein into the validated pharmacophore models; assigning a score to each pharmacophore model of the Imatinib drugin order to identify the validated pharmacophore models with a high binding affinity and efficiency; and comparing the score obtained from the ligand-based virtual screening (first virtual screening) and the structure-based virtual screening (second virtual screening) for classifying the scored pharmacophore models based on the target protein binding affinity and efficiency for the coronaviridae family of virus.
5.3093147AN AUTOMATED, CLOUD-BASED, POINT-OF-CARE (POC) PATHOGEN AND ANTIBODY ARRAY DETECTION SYSTEM AND METHOD
CA 17.11.2020
Int.Class G01N 35/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
Appl.No 3093147 Applicant AUTONOMOUS MEDICAL DEVICES INC. Inventor

An automated method of assaying a viral and antibody analyte in a sample in a
portable, handheld microfluidic reader having a SAW detector with a minimal
mass
sensitivity limitation includes the steps of automatically performing the
assay with the
SAW detector with enhanced sensitivity, but also includes the steps of
automatically
disposing a second portion of the sample on a microarray, selectively
automatically
probing the second portion of the sample for antibodies corresponding to the
at least one
selected virus using the microarray, and automatically reading the microarray
using a
fluorescent camera to identify antibodies in the second portion of the sample.

6.202111010632A NOVEL DRUG FOR SARS-COV-2
IN 28.05.2021
Int.Class G16B /
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
Appl.No 202111010632 Applicant Abhay J. Gandhi Inventor Abhay J. Gandhi
COVID-19, a new strain of coronavirus (CoV), was identified in Wuhan, China, in 2019. It then extended across the globe and was termed as pandemic in 2020. Though no vaccine or drug is available to combat this disease, it is necessary to look over it through alternative sciences. Available symptoms of covid 19 was thoroughly studied and reviewed through Ayurveda classics to understand the nature of the disease into Ayurevdic perspective. Other available sources from internet, pre prints, etc. The molecular Docking were done by Pyrx Software with Autodock. The Lipinski Rule of Five data generated from Swiss ADME software and Target prediction of selected phytoconstituents were done from Swiss target prediction.In Ayurveda, it can be considered as Janapadaudhwans, vaat-kafaj sannipatik jwara, Aupsargik vyadhi and Dhatupaka awastha. In the molecular docking study the binding energy and inhibition of 6 Gingesulphonic acid from Zingiber Officinalis are greater than Hydroxychloroquine and quinine. Most of the selected phytoconstituents follow Lipinski rule of five. Target prediction of selected phytoconstituents were done on target of SARS-COV-2, humoral immunity and antiviral. Every selected phytoconstituents were work on minimum of the target.Thus, from the above results obtained from reviewing Ayurveda classics and from the results obtained after virtual screening of selected drugs we can conclude that Ayurveda drugs can have appreciable results in combating Covid 19.
7.3098079APPARATUS AND METHOD FOR POINT-OF-CARE, RAPID, FIELD-DEPLOYABLE DIAGNOSTIC TESTING OF COVID-19, VIRUSES, ANTIBODIES AND MARKERS - AUTOLAB 20
CA 19.03.2021
Int.Class G01N 21/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
Appl.No 3098079 Applicant AUTONOMOUS MEDICAL DEVICES, INC. Inventor

An automated system communicated to a remote server for diagnostically field
testing a
sample taken from a patient using an automated portable handheld instrument to

determine the presence of Covid-19 and/or antibodies thereto includes
microfluidic
circuits defined in a rotatable disk for performing a bioassay using a
microarray to
generate an electrical signal indicative of a bioassay measurement; the
microarray
operationally positioned in the microfluidic circuit; one or more lasers; one
or more
positionable valves in the microfluidic circuit; and a backbone unit for
rotating the disk
according to a protocol to perform the bioassay, for controlling the lasers to
selectively
open the positionable valves in the microfluidic disk, for operating the
microarray to
generate a digital image as a bioassay measurement; for communicating the
bioassay
measurement to the remote server, and for associating the performed bioassay
and its
corresponding bioassay measurement to the patient.

8.20210102197DESIGNING SENSITIVE, SPECIFIC, AND OPTIMALLY ACTIVE BINDING MOLECULES FOR DIAGNOSTICS AND THERAPEUTICS
US 08.04.2021
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No 17065504 Applicant THE BROAD INSTITUTE, INC. Inventor Pardis SABETI

The invention provides for methods for designing sensitive, specific, and optimally active binding molecules. Systems, methods and compositions utilizing the designed molecules in diagnostics and therapeutics are also provided.

9.20210142868METHODS AND SYSTEMS FOR IDENTIFYING, CLASSIFYING, AND/OR RANKING GENETIC SEQUENCES
US 13.05.2021
Int.Class G16B 30/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
30ICT specially adapted for sequence analysis involving nucleotides or amino acids
10Sequence alignment; Homology search
Appl.No 17095562 Applicant Regeneron Pharmaceuticals, Inc. Inventor Richard Copin

The present disclosure provides methods and systems for analysis of genomic sequence information. The present disclosure provides, among other things, methods and systems for characterizing sequence conservation. As is discussed herein, certain methods and systems of the present disclosure include assignment of a similarity score to a sequence or pairwise sequence comparison based on a measure of coverage and a measure of identity between two aligned sequences.

10.WO/2020/198865OLIGOPEPTIDES FOR QUANTITATIVE VIRAL PROTEOMIC ANALYSIS METHODS AND USES
WO 08.10.2020
Int.Class C07K 14/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
Appl.No PCT/CA2020/050431 Applicant THE UNIVERSITY OF BRITISH COLUMBIA Inventor JEAN, François
Provided are purified oligopeptides, labelled oligopeptides, and stable isotope labelled oligopeptides, methods for their use in determining the maturation status of the flaviruses or coronaviruses in a human biological sample. The purified oligopeptides, labelled oligopeptides, and stable isotope labelled oligopeptides may also be used to measure the level of the flavirus protein or coronavirus protein in a human biological sample. Methods are also provided for treating a subject based on the maturation status of the flaviruses or the coronaviruses in the subject's biological sample and/or based on the level of the flavirus or coronavirus protein in the subject's biological sample.