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Analysis

1.20210315970Hepatitis A Virus Replication Inhibitor Targeting mTOR
US 14.10.2021
Int.Class A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Appl.No 17227859 Applicant Tokyo Metropolitan Institute of Medical Science Inventor Daisuke Yamane

[Problem to be solved] To provide a pharmaceutical composition for treating a disease caused by an RNA virus.

[Solution] A pharmaceutical composition for a disease caused by an RNA virus or an inhibitor of RNA virus replication, comprising retinoic acid receptor responder protein 3 and/or an mTOR inhibitor.

2.WO/2021/203448MULTIPLEX FLUORESCENT RT-PCR DETECTION REAGENT FOR DETECTING COASTAL INPUT SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2
WO 14.10.2021
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/CN2020/084399 Applicant BEIJING CUSTOMS DISTRICT P.R.CHINA Inventor ZHANG, Xiquan
Provided are a multiplex fluorescent PCR primer, a probe and a kit for identifying severe acute respiratory syndrome coronavirus 2. The primer is shown as sequences SEQ ID No. 1 to SEQ ID No. 10, and the probe is shown as sequences SEQ ID No. 11 to SEQ ID No. 15. Further provided are a detection kit comprising the primer and the probe and a detection method therefor, being able to achieve the purpose of accurately detecting SARS‐Cov‐2 in a sample to be detected.
3.WO/2021/207576QUALITATIVE AND QUANTITATIVE DETERMINATION OF SINGLE VIRUS HAPLOTYPES IN COMPLEX SAMPLES
WO 14.10.2021
Int.Class C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
Appl.No PCT/US2021/026530 Applicant TAKEDA VACCINES, INC. Inventor DEAN, Hansi
The present invention provides methods for detecting the presence of at least one revertant virus in a sample containing an attenuated virus by single-molecule real-time (SMRT) sequencing. It further provides methods for the quantitative analysis of a mixture of virus haplotypes in a virus sample by SMRT sequencing. It also provides kits useful in performing said methods.
4.WO/2021/204886METHOD FOR A RAPID DETECTION OF A SARS-COV-2 INFECTION
WO 14.10.2021
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/EP2021/059081 Applicant EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET Inventor IFTNER, Thomas
The present invention relates to a method for a rapid detection of an infection or non-infection of a living being with SARS-CoV-2, a new starting material for said detection via loop-mediated isothermal amplification (LAMP), and to a kit for performing said method.
5.WO/2021/204701RAPID DETECTION OF VIRAL INFECTION USING RT-PCR
WO 14.10.2021
Int.Class C12Q 1/6844
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
Appl.No PCT/EP2021/058720 Applicant BAYER AKTIENGESELLSCHAFT Inventor GOLZ, Stefan
A lysis buffer comprising one non-ionic surfactant is provided which can be used as a one-step reagent of the preparation, storage, amplification, and/or detection of nucleic acids. Various embodiments of the lysis buffer of the invention comprise other substances that are compatible or useful in lysing cells, storing nucleic acids, amplifying nucleic acids, purifying nucleic acids, detecting nucleic acids, and/or other procedures for analysis of nucleic acids. Methods and kits based on the lysis buffer are also provided, including those for rapid lysis of cells and direct use of the resulting cell lysates in RT-PCR.
6.WO/2021/204642PCR BASED DIAGNOSTIC KIT, COMPOSITIONS AND METHODS FOR AMPLIFICATION AND DETECTION OF SARS-COV-2
WO 14.10.2021
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/EP2021/058556 Applicant FAST TRACK DIAGNOSTICS LUXEMBOURG S.À.R.L. Inventor EDUARDO CORREIA, Benedito
The present application is directed to a method for detecting presence or absence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in a sample. The method first involves contacting the sample with a primary oligonucleotide primer set. The primary oligonucleotide primer set comprises: (i) a first oligonucleotide primer comprising a nucleotide sequence complementary to a first portion of the SARS-CoV-2 transmembrane domain 2 gene, and (ii) a second oligonucleotide primer comprising a nucleotide sequence complementary to an extension product formed from the first oligonucleotide primer of the primary oligonucleotide primer set. The method can further involve contacting the sample with a secondary oligonucleotide primer set, where the secondary primer set comprises (i) a first oligonucleotide primer comprising a nucleotide sequence complementary to a first portion of the SARS-CoV-2 N gene, and (ii) a second oligonucleotide primer comprising a nucleotide sequence complementary to an extension product formed from the first oligonucleotide primer of the secondary oligonucleotide primer set. The contacted sample is subjected to an amplification reaction under conditions suitable for producing transmembrane domain 2 gene and N gene amplification products, and the presence or absence of SARS-CoV-2 in the sample is detected. Isolated oligonucleotides, primer sets, and kits are also disclosed.
7.WO/2021/205453METHODS FOR NUCLEIC ACID DETECTION
WO 14.10.2021
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
Appl.No PCT/IL2021/050400 Applicant YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. Inventor SADEH, Ronen
Methods of preparing cDNA from a sample comprising RNA are provided. Methods of simultaneously detecting an infectious agent in a plurality of samples obtained from a plurality of subjects are also provided, as is a kit for performance of the methods of the invention.
8.WO/2021/204479DEVICE AND METHOD FOR PHOTOTHERMAL ENHANCED PLASMONIC BIOSENSING
WO 14.10.2021
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/EP2021/055906 Applicant EMPA EIDGENÖSSISCHE MATERIALPRÜFUNGS- UND FORSCHUNGSANSTALT Inventor QIU, Guangyu
The present invention is directed to a dual-functional plasmonic detector comprising (a) a photothermal unit configured to generate a monochromatic light beam; (b) a plasmonic sensing unit configured to introduce a localized surface plasmon resonance effect and to transduce a target sample by means of a polychromatic radiation beam; and (c) a detection unit configured to detect plasmonic characteristics by recording and processing the radiation beam altered by the plasmonic sensing unit. The invention also relates to the use of the dual-functional plasmonic detector of the invention for detecting, quantifying and/or characterizing a target sample, in particular for detecting, quantifying and/or characterizing a nucleic acid or a virus, e.g. a coronavirus such as SARS-CoV or SARS-CoV-2.
9.WO/2021/204630METHOD FOR THE DETECTION AND QUANTIFICATION OF HUMAN CYTOMEGALOVIRUS BY MEANS OF VIRION RNAS
WO 14.10.2021
Int.Class C12Q 1/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
70involving virus or bacteriophage
Appl.No PCT/EP2021/058497 Applicant ELITECHGROUP S.P.A. Inventor MASTRAPASQUA, Eleonora
A method for the detection and/or quantification of a human cytomegalovirus (hCMV) virion mRNA in a sample obtained from a patient to identify and/or quantify hCMV infection. The invention also relates to oligonucleotides specific for hCMV virion mRNA and to a kit for the detection and/or quantification of hCMV virion mRNA.
10.WO/2021/207091PATHOGEN DIAGNOSTIC TEST
WO 14.10.2021
Int.Class C12Q 1/6853
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6853using modified primers or templates
Appl.No PCT/US2021/025806 Applicant OCTANT, INC. Inventor KOSURI, Sriram
Described herein are methods useful for detecting and diagnosing pathogen infection using PCR and sequencing.