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1.WO/2021/204338PRODUCTION OF GERANYL DIPHOSPHATE-DERIVED COMPOUNDS
WO 14.10.2021
Int.Class C12N 9/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
04acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
Appl.No PCT/DK2021/050098 Applicant KØBENHAVNS UNIVERSITET Inventor KAMPRANIS, Sotirios
Disclosed is yeast cells having peroxisomally localized GPP synthase and a peroxisomally localized enzyme that converts GPP into a monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds; or a precursor therefore, which yeast cells are capable of producing improved amounts of monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds, compared with the same yeast cells where the GPP synthase and the enzyme that converts GPP are located in the cytoplasm. Further disclosed is the use of the yeast cell for producing monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds.
2.WO/2021/206183FUNCTIONAL POLYPEPTIDES AND USE THEREOF
WO 14.10.2021
Int.Class C12N 15/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
Appl.No PCT/JP2021/015369 Applicant NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY Inventor SAKAI, Ryuichi
A polypeptide that comprises the amino acid sequence of SEQ ID NO: 1 and has a function of delivering a substance into cells, a polypeptide that comprises the amino acid sequence of SEQ ID NO: 2 and has a function of degrading a nucleic acid molecule, a polypeptide that comprises the amino acid sequence of SEQ ID NO: 3 and has a function of degrading a nucleic acid molecule and a function of intranuclearly migrating the same, polynucleotides encoding the respective polypeptides, and transformed cells containing the respective polynucleotides.
3.WO/2021/206573A METHOD FOR PROCESSING RAW PLANT MATERIAL, ESPECIALLY LEGUMES INTO PROTEIN HAVING A NUTRITIONAL AND FEED VALUE, BIOETHANOL, BIOGAS AND FERTILISER MATERIALS
WO 14.10.2021
Int.Class A23L 11/00
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
11Pulses, i.e. fruits of leguminous plants, for production of fodder or food; Products from legumes; Preparation or treatment thereof, e.g. treatment with phosphates
Appl.No PCT/PL2021/050022 Applicant BIOTECHNIKA TOMASZ KAPELA Inventor KAPELA, Tomasz
A method for processing raw plant material, especially legumes into protein having a nu-tritional and feed value, bioethanol, biogas and fertiliser materials characterised in that the rawplant material is subjected to a dehusking process, followed by the dehusked raw material beingcrushed and subjected to extraction with stirring, wherein the insoluble solid fraction is separatedand subjected to enzymatic hydrolysis using liquefying and saccharifying enzymes, thensubjected to ethanol fermentation, where the produced ethanol is distilled and the digestate istransferred as a substrate for biogas production, and the liquid fraction after the extractionprocess is subjected to a process of precipitation to a solid form in the form of protein precipitate,which is washed with extraction buffer, after which the liquid residue is removed and subjectedto a biogasification process, and the wet biogas residue is used as a fertiliser or formed into drypellets and used as an organic fertiliser.
4.20210317481USE OF METAL SALTS AND DEEP EUTECTIC SOLVENTS IN A PROCESS TO SOLUBILIZE A BIOMASS
US 14.10.2021
Int.Class C12P 7/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
04acyclic
06Ethanol, i.e. non-beverage
08produced as by-product or from waste or cellulosic material substrate
10substrate containing cellulosic material
Appl.No 17220846 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor Lalitendu Das

The present invention also provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent to a biomass to dissolve at least part of solid biomass in the solvent, wherein the solvent comprises (i) a metal salt, and (ii) an ionic liquid (IL) or deep eutectic solvent (DES), or mixture thereof, to form a solubilized biomass mixture; (b) optionally introducing an enzyme and/or a microbe to the composition such that the enzyme and/or microbe produce a biofuel and/or chemical compound from the solubilized biomass; and, (c) optionally the biofuel and/or chemical compound is separated from the composition.

5.WO/2021/205299PROCESS FOR PREPARING PHENYLACETIC ACID
WO 14.10.2021
Int.Class C12P 7/40
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
40containing a carboxyl group
Appl.No PCT/IB2021/052744 Applicant CONSIGLIO NAZIONALE DELLE RICERCHE Inventor CASTAGNA, Antonio
Process for preparing phenylacetic acid according to the invention, essentially comprising the steps of: providing one or more yeast strains belonging to the genus Yarrowia and mutants thereof; providing a culture medium including phenylalanine; transforming phenylalanine into phenylacetic acid by fermentation of said one or more yeast strains in the culture medium, said phenylacetic acid being contained in a fermentation broth obtained by said fermentation; isolating the phenylacetic acid from said fermentation broth.
6.20210317486METHOD OF PREPARING PRIMARY AMINES FROM AMINO ACIDS USING ENZYMATIC CONVERSION
US 14.10.2021
Int.Class C12P 13/08
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta-amino acids
08Lysine; Diaminopimelic acid; Threonine; Valine
Appl.No 17194222 Applicant KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY Inventor Sang Yup LEE

Disclosed is a method of preparing primary amines. More particularly, disclosed are a mutant microorganism transformed with a gene encoding a valine decarboxylase and a method of preparing primary amines from amino acids using the mutant microorganism. The method has an effect of synthesizing, in an environmentally friendly manner, primary amines as precursors for pharmaceuticals and agricultural chemicals using microorganisms, as an alternative to conventional chemical synthesis methods.

7.20210317493FERMENTATIVE PRODUCTION OF OLIGOSACCHARIDES BY TOTAL FERMENTATION UTILIZING A MIXED FEEDSTOCK
US 14.10.2021
Int.Class C12P 19/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
12Disaccharides
Appl.No 17273447 Applicant Jennewein Biotechnologie GmbH Inventor Stefan JENNEWEIN

Disclosed are genetically engineered microbial cells for the production of oligosaccharides comprising a galactose-β1,4-glucose moiety at their reducing end, wherein said microbial cells are able to produce said oligosaccharides in the absence of exogenously added lactose, and a method of producing said oligosaccharides using said microbial cells.

8.20210317496Methods and Compositions for Increased Capping Efficiency of Transcribed RNA
US 14.10.2021
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Appl.No 17357442 Applicant New England Biolabs, Inc. Inventor Bijoyita Roy

Methods and compositions for capping RNA in an in vitro transcription mixture are provided that include a thermostable RNA polymerase variant and a cap analog such that when a DNA template is added to the mixture, and the mixture is then incubated under conditions for in vitro transcription, capped RNA is produced.

9.20210317490ANTICANCER COMPOUNDS
US 14.10.2021
Int.Class C12P 17/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
02Oxygen as only ring hetero atoms
06containing a six-membered hetero ring, e.g. fluorescein
Appl.No 16494720 Applicant Pharma Mar, S.A. Inventor Librada María CAÑEDO HERNÁNDEZ

Anticancer compounds of general formula I

embedded image

  • wherein R1 to R4 take various meanings, for use in the treatment of cancer. A novel Labrenzia sp. strain named PHM005 with Accession Deposit Number CECT-9225, a method of producing compounds of the invention and analogues thereof by using the PHM005 strain and the Lab gene cluster codifying the biosynthesis of pederin-like and onnamide-like compounds are also provided.

10.WO/2021/204095METHOD AND EQUIPMENT OF PHENETHYLAMINE PRODUCTION
WO 14.10.2021
Int.Class C12M 1/40
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
40Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
Appl.No PCT/CN2021/085499 Applicant ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. Inventor YANG, Zhuhong
Provided is a production equipment of phenethylamine, comprising a first reaction device (1); a second reaction device (2), wherein the second reaction device (2) is connected to the first reaction device (1); and a circulation device (4), the circulation device (4) is respectively connected to the first reaction device (1) and the second reaction device (2); an acetone storage device (5); a centrifugal extraction device (6); a phenethylamine processing device; a phenethylamine storage device (10); wherein the first reaction device (1) and the second reaction device (2) have the same structure. Also provided is a production method of phenethylamine, which uses transaminase as a catalyst, so that acetophenone and isopropylamine can flow through the transaminase to complete the reaction, the reaction is completed in one step, the production cycle is shortened, and the production cost is reduced.