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Analysis

1.20210315838SYSTEMS, METHODS, AND KITS FOR DIAGNOSTICS AND TREATMENT OF VIRAL RESPIRATORY INFECTION
US 14.10.2021
Int.Class A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
Appl.No 17301188 Applicant Applied Biology, Inc. Inventor Ofer A. Goren

The present disclosure includes methods, systems, kits and compositions for treating, preventing and diagnosing viral infections, specifically SARS-CoV-2 infections, with an anti-androgen and anti-thyroid medication, a thyroid receptor antagonist, a TGF-β inhibitor or a combination thereof. The present disclosure also describes methods and compositions for the treatment of viral respiratory diseases, specifically SARS-CoV-2 infections, including anti-androgens, anti-thyroid medications, thyroid receptor antagonists, TGF-β inhibitors, RXR inhibitors, furin inhibitors or other agents to disrupt the androgen signaling.

2.20210317466EXPRESSION OF UNFOLDED PROTEIN RESPONSE PROTEINS IMPROVES PLANT BIOMASS AND GROWTH
US 14.10.2021
Int.Class C12N 15/82
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
Appl.No 17051683 Applicant Board of Trustees of Michigan State University Inventor Federica Brandizzi

Described herein are expression cassettes, plant cells, plant seeds, plants, and methods useful for improving the glucan content and growth of plants.

3.20210317170COMPOSITIONS AND METHODS FOR DRUG DELIVERY AND TREATING VIRAL INFECTIONS
US 14.10.2021
Int.Class C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Appl.No 17086957 Applicant UT-Battelle, LLC Inventor Joseph Christopher Ellis

The present disclosure is directed to compositions and methods for targeted drug delivery that comprise a biocompatible framework carrying at least one drug and a viral surface protein, where the viral surface protein mediates entry into a target cell and is attached to an outer surface of the biocompatible framework in the drug carrier.

4.20210317440ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF
US 14.10.2021
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No 17148059 Applicant President and Fellows of Harvard College Inventor David R. LIU

The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA. The disclosure also provides fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA. In some embodiments, the fusion proteins further comprise a nuclear localization sequence (NLS), and/or an inhibitor of base repair, such as, a nuclease dead inosine specific nuclease (dISN).

5.WO/2021/205208DEVICE FOR NORMALIZING HUMAN CELL GENE EXPRESSION AND WEAKENING CORONAVIRUS GENE EXPRESSION USING MAGNETIC AND ELECTROMAGNETIC FIELDS
WO 14.10.2021
Int.Class A61N 2/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
2Magnetotherapy
02using magnetic fields produced by coils, including single turn loops or electromagnets
Appl.No PCT/IB2020/053348 Applicant HASHEMI, Ali Inventor HASHEMI, Ali
The invention of device for normalizing human cell gene expression and weakening coronavirus gene expression using magnetic and electromagnetic fields which by making magnetic field and controlling the intensity, direction and wave length using servomotors, supports and electromagnetic wave generation module can make some changes in gene expression of viruses like corona to prevent from propagation and spread of virus. Also the magnetic field by making some natural changes in gene expression of human cells cause to indispose the environment for the propagation and growth of viruses and as a result cause the virus to be semi active. This magnetic field allows to treat the diseases with metabolic, bacterial, microbial and genetically origins.
6.WO/2021/206183FUNCTIONAL POLYPEPTIDES AND USE THEREOF
WO 14.10.2021
Int.Class C12N 15/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
Appl.No PCT/JP2021/015369 Applicant NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY Inventor SAKAI, Ryuichi
A polypeptide that comprises the amino acid sequence of SEQ ID NO: 1 and has a function of delivering a substance into cells, a polypeptide that comprises the amino acid sequence of SEQ ID NO: 2 and has a function of degrading a nucleic acid molecule, a polypeptide that comprises the amino acid sequence of SEQ ID NO: 3 and has a function of degrading a nucleic acid molecule and a function of intranuclearly migrating the same, polynucleotides encoding the respective polypeptides, and transformed cells containing the respective polynucleotides.
7.WO/2021/206633METHODS AND COMPOSITIONS FOR TREATING LIVER CANCER
WO 14.10.2021
Int.Class A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Appl.No PCT/SG2021/050191 Applicant ENGINE BIOSCIENCES PTE. LTD. Inventor HARRISON, Stephen
Methods and compositions for treating cancer, such as liver cancer, are disclosed herein. The methods may comprise use of therapeutically effective amounts of one or more therapeutic agents to decrease expression or activity of Aurora kinase A (AURKA) in liver cancer cells that are deficient in AT-rich domain interactive domain 1A (ARID1A). In a preferred embodiment, the one or more therapeutic agents comprises a DNA construct encoding Cas9 and a guide RNA targeting AURKA gene.
8.WO/2021/207158REUSABLE INITIATORS FOR SYNTHESIZING NUCLEIC ACIDS
WO 14.10.2021
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Appl.No PCT/US2021/025918 Applicant MOLECULAR ASSEMBLIES, INC. Inventor AGARWALLA, Sanjay
The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
9.WO/2021/207353IMPROVING PLANT NUTRITIONAL VALUE AND GROWTH THROUGH ENHANCEMENT OF ESSENTIAL AMINO ACID LEVELS
WO 14.10.2021
Int.Class C12N 15/82
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
82for plant cells
Appl.No PCT/US2021/026166 Applicant BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY Inventor BRANDIZZI, Federica
Described herein are modified isopropylmalate synthase nucleic acids and proteins, as well as methods, plants, plant cells, and seeds that include the modified isopropylmalate synthase. As shown herein, plants and seeds with such modified isopropylmalate synthase nucleic acids and proteins have increased biomass and/or increased amino acid content.
10.WO/2021/207653USE OF A TLR9 AGONIST IN METHODS FOR TREATING COVID-19
WO 14.10.2021
Int.Class A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
Appl.No PCT/US2021/026657 Applicant IDERA PHARMACEUTICALS, INC. Inventor CHUNDURU, Srinivas
The present invention is directed to use of tilsotolimod in the treatment of coronavirus infection, for example, SARS-CoV2, and COVID-19.