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Analysis

1 / 20,157
1.WO/2025/137909MANGOSTEEN PERICARP ENZYME FERMENTATION APPARATUS
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/CN2023/142231 Applicant GUANGZHOU INSTITUTE OF TECHNOLOGY AND BUSINESS Inventor LIU, Hua
A mangosteen pericarp enzyme fermentation apparatus, comprising a tank body, a movement mechanism, a feed mechanism, a covering mechanism and a clamping mechanism. An upper end of the tank body is provided with the movement mechanism, an upper end of the movement mechanism is provided with the feed mechanism, a lower end of the feed mechanism is provided with the covering mechanism, and a lower end of the covering mechanism is provided with the clamping mechanism. By means of placing a cloth bag within a first fixed plate and a first sliding plate, mangosteen pericarp can uniformly contact a fermentation liquid. During movement of a hydraulic cylinder towards one end, a rotating body is driven to evenly spread the mangosteen pericarp inside a feed hopper into the cloth bag. The inside of the outer shell is in a sealed state, and the mangosteen pericarp and the fermentation liquid therein ferment to produce enzymes. While a second sliding plate moves towards one end, a sliding plate is driven to move towards one end to squeeze the mangosteen pericarp in the cloth bag, so that the cloth bag is flattened and evenly distributed between the first fixed plate and the first sliding plate.
2.WO/2025/138284ARRAY AND METHOD FOR DETECTING SPATIAL INFORMATION OF NUCLEIC ACIDS
WO - 03.07.2025
Int.Class C12Q 1/6874
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
6874involving nucleic acid arrays, e.g. sequencing by hybridisation
 Appl.No PCT/CN2023/143677 Applicant BGI SHENZHEN Inventor LIAO, Sha
The present application provides a nucleic acid array for detecting spatial information of nucleic acids in a sample, a method for detecting spatial information of nucleic acids in a sample on the basis of the array, and a method for producing the nucleic acid array.
3.WO/2025/140189CELL CULTURE SYSTEM AND BIOREACTOR
WO - 03.07.2025
Int.Class C12M 1/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
 Appl.No PCT/CN2024/141826 Applicant LOLMO INSTRUMENT CO., LTD. Inventor HU, Gengxi
The present application provides a cell culture device and a bioreactor. The culture device comprises: a mixer for mixing substances required for cell culture, the mixer comprising a mixing container and a mixing drive member, the mixing container providing a sealed mixing space and being in communication with the outside via a first interface and a second interface, and the mixing drive member being capable of driving substances to be mixed to move and mix; and a bioreactor comprising a reaction container and a plurality of culture dishes, the reaction container providing a closed space, and the plurality of culture dishes being disposed within the closed space. The closed space is in communication with the outside via a third interface and a fourth interface, the third interface may communicate with the second interface of the mixer, and the fourth interface may communicate with the first interface of the mixer, thereby providing perfusion culture within the bioreactor.
4.WO/2025/140774BIOPROCESS CHAMBER WITH FRUSTUM-SHAPED SECTION
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/EP2023/087909 Applicant LIMULA SA Inventor PIERSON, Yann
The invention refers to a processing chamber (100) shaped concentric around a center axis (101). The processing chamber (100) comprises a conical frustum shaped first body section (1) with a first base side (11) and a second base side (12). The second base side (12) opens into a second body section (2). The second body section extends along the center axis (101) with a first end of the second body section (2) pointing away from the first body section (1). The first end of the second body section (2) opens into a third body section (3). The third body section extends along the center axis (101) with a first end of the third body section (3) pointing in a direction away from the second body section (2) and wherein the first end of the third body section (3) is tapering into a second end (30) of the processing chamber (100).
5.WO/2025/142889DEVICE FOR CLASSIFYING EXTRACELLULAR VESICLES, AND IN VITRO METHOD FOR CLASSIFYING EXTRACELLULAR VESICLES AND DETECTING OR ANALYZING PROTEINS CONTAINED IN EXTRACELLULAR VESICLES
WO - 03.07.2025
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
 Appl.No PCT/JP2024/045586 Applicant BIOPHENOMA INC. Inventor SHIGA Hatsuki
The present disclosure relates to a device for classifying extracellular vesicles. The present disclosure also relates to an in vitro method for classifying extracellular vesicles and detecting or analyzing proteins contained in extracellular vesicles.
6.WO/2025/141179GAS EXCHANGE DEVICE FOR CELL CULTURE BIOREACTOR
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/EP2024/088599 Applicant SUPRÊME Inventor DE JONGH, Nicolaas Willem
The invention relates to a gas exchange device (1), for cell culture bioreactor (100), having a backbone hollow structure (10), such as a hollow cylindrical structure (10), wherein said backbone hollow structure (10) has an aspect ratio of at least five, and said gas exchange device (1) further comprising a gas exchange membrane (20) supported by the backbone hollow structure (10), the gas exchange membrane (20) having a gas permeability of at least 100 cm³/m².d.bar.
7.WO/2025/142709FILTER DEVICE, FILTRATION DEVICE, AND CELL CULTURE SYSTEM
WO - 03.07.2025
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/JP2024/044920 Applicant MITSUBISHI HEAVY INDUSTRIES, LTD. Inventor OKAMOTO Shinichi
A filter device according to the present disclosure comprises: a first filter that filters a culture solution by passing it downward; a second filter that is disposed below the first filter, is finer than the first filter, and filters the culture solution having passed through the first filter; and a first seal portion that seals a gap between the outer peripheral edge of the first filter and the outer peripheral edge of the second filter.
8.WO/2025/143024METHOD FOR PRODUCING HYDROGEL OR DRIED HYDROGEL, HYDROGEL OR DRIED HYDROGEL, COLLAGEN PATHOLOGICAL MODEL OR COLLAGEN AGING MODEL, AND CULTURED MEAT
WO - 03.07.2025
Int.Class C07K 14/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin
 Appl.No PCT/JP2024/045914 Applicant KAKE EDUCATIONAL INSTITUTION Inventor TAKEZAWA Toshiaki
Provided is a method for producing a hydrogel or dried hydrogel having a desired shape, the method having: a step 1 for injecting a colloid solution into a container having a prescribed shape, at least a part of which has a separation membrane; and a step 2 for placing the container in a liquid phase or in a gas phase and gelling the colloid solution in the container to obtain a hydrogel.
9.WO/2025/145019MICROENGINEERED TRANSPLANTATION OF HUMAN SOLID TUMORS FOR IN VITRO STUDIES OF CAR T IMMUNOTHERAPY
WO - 03.07.2025
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/US2024/062077 Applicant THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA Inventor HUH, Dongeun
A microfluidic chip for in vitro culture, comprising: a chamber, the chamber comprising a primary channel and at least one side channel adjacent thereto, the chamber having a bottom surface and a top surface, the chamber being configured as an open-top chamber having at least one aperture extending through the top surface and in fluid communication with the primary channel; and a separator disposed between the primary channel and the at least one side channel, the separator extending from the bottom surface of the chamber toward the top surface of the chamber; and optionally, an insert, the insert having at least one projection configured obstruct access to the aperture when the projection is placed into register with the one aperture. A method, comprising: contacting a solid tumor cell residing in the primary channel of a microfluidic chip and a sample cell perfused to the primary channel.
10.WO/2025/145124TARGET CELL SELECTION AND RELEASE USING MICROBUBBLE TECHNOLOGY IN A CELL PROCESSING SYSTEM
WO - 03.07.2025
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/US2024/062195 Applicant TRENCHANT BIOSYSTEMS, INC. Inventor COELHO, Philip, H.
A cell processing platform and method for selecting and isolating target cells, such as T-cells, NK-cells, or hematopoietic stem cells, from a biological sample using functionalized microbubbles. The platform employs microbubbles with lipid shells, functionalized with streptavidin and biotinylated linkers, to bind specific target cells and render them buoyant within the suspension. A centrifugation module separates non-target cells by sedimentation while maintaining the buoyancy of target cell-microbubble complexes. A pneumatic control system disrupts the microbubbles under controlled pressure or frequency, releasing the target cells for downstream processing without compromising viability. Additional features include a microbubble generation module capable of sequentially functionalizing ligands for multi-step cell selection and a temperature-controlled environment to ensure ligand stability. The system supports non-destructive cell release and sorting, enabling precise, contamination-free, and high-efficiency cell isolation for therapeutic and research applications.
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