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1 / 3,244
1.WO/2024/092347CELL CULTURE DEVICES
WO - 10.05.2024
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/CA2023/051446 Applicant VAL-CHUM, LIMITED PARTNERSHIP Inventor LAURENT, Etienne
A cell culture device comprising: a chip component having: a top face and a bottom face, a channel formed in the chip component which is open at the top face and has a base spaced from the bottom face; a well portion extending from the base of the channel to the bottom face of the chip component, the well portion being open at the bottom face of the chip component and at the base of the channel; and a membrane component configured to be positioned on the bottom face of the chip component to close the open well portion, the membrane component having a porous portion which is aligned with the open well portion when the membrane component and the chip component are assembled together, the porous portion of the membrane component being permeable to gas and impermeable to liquid.
2.WO/2024/093788DISPOSABLE FIXED BED FOR ADHERENT CELL CULTURE
WO - 10.05.2024
Int.Class C12M 3/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
04with means providing thin layers
 Appl.No PCT/CN2023/126806 Applicant TOFFLON LIFE SCIENCE CO., LTD Inventor SUN, Minggang
Provided is a disposable fixed bed for adherent cell culture, comprising a pump casing, an upper cover plate, an annular pressing plate, a carrier, an annular bottom plate, a first supporting seat, a second supporting seat, a sealing connection mechanism, and a magnetic stirring mechanism. The annular bottom plate, the first supporting seat, and the second supporting seat are sequentially arranged on the pump casing from bottom to top. The upper cover plate is in a sealed connection to the pump casing. Stirring blades of the magnetic stirring mechanism are sleeved on a connecting column at the bottom of the pump casing. The first supporting seat and the second supporting seat jointly form one carrier supporting seat. The annular pressing plate and an annular groove structure of the carrier supporting seat jointly form one accommodating space. The carrier is arranged in the accommodating space. In the provided disposable fixed bed for adherent cell culture, curtain-type oxygen exchange is achieved by means of a specific fluid channel, and the stirring blades are arranged outside a space for cell growth, so as to overcome the defects that an existing cell culture apparatus occupies a large area, is too labor-intensive, is prone to bacterial contamination, has high shear force, and has a small amount of dissolved oxygen.
3.WO/2024/096098MICROFLUIDIC DEVICE AND METHOD FOR USING MICROFLUIDIC DEVICE
WO - 10.05.2024
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/JP2023/039607 Applicant TOHOKU INSTITUTE OF TECHNOLOGY Inventor SUZUKI,Ikuro
The microfluidic device is equipped with a first chamber that is capable of culturing nerve cells and a channel that extends laterally from the first chamber and is capable of culturing neurites extending from the nerve cells. The channel has a first end that communicates with the first chamber and a second end opposite the first end. The channel has a barrier portion, located away from the second end, that lowers the height of part of the ceiling surface of the channel to limit the infiltration of nerve cells.
4.WO/2024/092343CELL CULTURE BIOREACTOR WITH ROTATIONAL MIXING
WO - 10.05.2024
Int.Class C12M 3/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
06with filtration, ultrafiltration, inverse osmosis or dialysis means
 Appl.No PCT/CA2023/051381 Applicant ABEC, INC. Inventor PUNDSACK, Andrew Michael
A cell culture bioreactor has hollow fiber membranes within an extra-capillary space optionally used to grow cells in suspension. The membranes may include liquid perfusion membranes and/or gas transfer membranes. Liquid medium moves within the extra-capillary space relative to the membranes. The bioreactor may be rotated clockwise and counter- clockwise in a repeated pattern around an axis of rotation passing through the bioreactor. The axis of rotation may be horizontal, pass trough the center of the bioreactor and/or be perpendicular to the membranes. The rotation pattern may include 5 or more reversals of direction and/or decelerations and acceleration (optionally stops and re-starts) in one direction per minute. The bioreactor my be rotated through less than 360 degrees of rotation in one direction and then through less than 360 degrees in the opposite direction. The rotation of the bioreactor may reach a speed in the range of 1 to 25 rpm.
5.WO/2024/095913PLATE CONTAINING RENAL CELL AGGREGATES, AND PHARMACOKINETICS TEST KIT, TOXICITY TEST KIT, AND DRUG DISCOVERY AND DEVELOPMENT KIT USING SAME
WO - 10.05.2024
Int.Class C12N 5/071
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
 Appl.No PCT/JP2023/038856 Applicant NIKKISO CO., LTD. Inventor TAKAHASHI, Etsushi
Provided is a means for further improving the accuracy of evaluations of pharmacokinetics, toxicity, and drug efficacy using cell aggregates from multiple samples. A plate having a plurality of wells, wherein the wells house a liquid and aggregates of renal cells; the openings of the wells are covered by a film; and the ratio of the total volume of the aggregates and the liquid to the entire volume of the wells is a predetermined ratio.
6.WO/2024/096138CULTURE DEVICE, METHOD FOR MONITORING CULTURE SUBJECT, AND CULTURE CHIP
WO - 10.05.2024
Int.Class C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
 Appl.No PCT/JP2023/039902 Applicant TOKAI UNIVERSITY EDUCATIONAL SYSTEM Inventor KIMURA Hiroshi
This culture device comprises a container body that houses a culture liquid, and a culture chip that forms a culture chamber inside the container body, wherein: the container body has a light-permeable and gas-permeable bottom wall; and the culture chip has a frame that is in contact with the top surface of the bottom wall, and a membrane member that is permeable to a liquid or a liquid-containing material and is fixed to the top surface of the frame to form the culture chamber together with the bottom wall and the frame.
7.WO/2024/095564METHOD FOR ESTIMATING METABOLIC FLUX DISTRIBUTION, ANALYSIS DEVICE, AND PROGRAM
WO - 10.05.2024
Int.Class G16B 5/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
5ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
 Appl.No PCT/JP2023/030109 Applicant SHIMADZU CORPORATION Inventor KUSANAGI, Toshihiro
Provided is a method for estimating the metabolic flux distribution of cells, the method comprising: a step for acquiring discharge data including time-series data of a substance discharged to the outside of the cells with respect to a first strain cell and a second strain cell that is a reference for comparison; a step for calculating a discharge flux of the substance to the outside of the cells on the basis of the discharge data; a step for estimating a plurality of primary flux patterns on the basis of the discharge flux; and a step for clustering the plurality of primary flux patterns on the basis of the mutual similarity of the plurality of primary flux patterns and then outputting the clustered result.
8.WO/2024/096090MICROPHYSIOLOGICAL SYSTEM
WO - 10.05.2024
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No PCT/JP2023/039543 Applicant RIKEN Inventor YOKOKAWA Ryuji
Disclosed is a microphysiological system comprising a microfluidic device, and human renal proximal tubular epithelial cells (RPTEC) and pluripotent stem cell-derived LTL-positive cells which are accommodated in the microfluidic device. The microfluidic device comprises a device body, a first chamber provided to the device body, a second chamber provided to the device body, and a porous membrane which is positioned between the first chamber and the second chamber, and separates the first chamber and the second chamber. The RPTEC and the LTL-positive cells are accommodated inside the first chamber and are attached to a first surface of the porous membrane facing the first chamber.
9.20240150691BILE DUCT CHIP AND USE THEREOF
US - 09.05.2024
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No 18280659 Applicant Kyoto University Inventor Kazuo TAKAYAMA

There is provided a bile duct chip that is a bile duct chip (200) including a membrane (210) through which substances are movable from one surface to the other surface, a first substrate (221) having a recessed part that forms a first flow path (220), and a second substrate (231) having a recessed part that forms a second flow path (230), in which the first substrate (221), the membrane (210), the second substrate (231) are stacked in this order, the recessed part of the first substrate (221) has an opening portion facing the one surface of the membrane (210), the recessed part of the second substrate has an opening portion facing the other surface of the membrane (210), the one surface of the membrane (210) forms a part of the first flow path (220), the other surface of the membrane (210) forms a part of the second flow path (230), the first flow path (220) and the second flow path (230) communicate with each other through the membrane (210), and bile duct epithelial cells (222) are disposed on a surface of an inner wall of the first flow path (220) to form a tube.

10.20240150692ORGAN CROSSTALK IN VITRO CHAMBER TO SIMULATE MULTI ORGAN TISSUES
US - 09.05.2024
Int.Class C12M 3/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3Tissue, human, animal or plant cell, or virus culture apparatus
 Appl.No 18476464 Applicant Government of the United States as represented by the Secretary of the Air Force Inventor Saber M. Hussain

In accordance with various embodiments of the disclosed subject matter, a system, device and platform for culturing and maintaining tissue representative cellular models combined with active fluidics mimicking body circulation. In combination, multiple chamber devices enable modeling of multi-organ communication, representative of in vivo conditions.

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