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Analysis

1 / 3,979
1.WO/2026/102087QUANTIFICATION OF TARGETS USING CYCLE-BY-CYCLE DATA COLLECTED ON A DIGITAL POLYMERASE CHAIN REACTION PLATFORM
WO - 15.05.2026
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
 Appl.No PCT/US2025/054304 Applicant LIFE TECHNOLOGIES CORPORATION Inventor LEONG, Harrison
A method for quantification of a target molecule of a biological sample distributed across a plurality of partitions is provided. The method includes receiving fluorescent emission data generated by a polymerase chain reaction (PCR) for each partition of a set of partitions and identifying a partition quantity metric for each partition in the set of partitions to generate a set of partition quality metrics. Each partition quantity metric correlates to a number of target molecules within its respective partition based on the fluorescent emission data. The set of partition quantity metrics is used to determine a state of target molecule amplification within each partition of the set of partitions. The method further includes determining a quantity of the target molecule in the biological sample based on the set of partition quantity metrics.
2.WO/2026/102132METHODS FOR DETECTION OF CANCER ANEUPLOIDY AND SELECTION OF SUBJECTS FOR ANTI-CANCER THERAPY THROUGH PLASMA WHOLE GENOME SEQUENCING
WO - 15.05.2026
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/US2025/054384 Applicant MEMORIAL SLOAN-KETTERING CANCER CENTER Inventor WIDMAN, Adam
Presented herein are systems and methods for selecting a subject for a cancer therapy based on detection of allelic imbalances in cell-free deoxyribonucleic acid (cfDNA) in a bodily fluid sample of the subject. A computing system may obtain, for a subject at risk of or diagnosed with cancer, a first sequencing dataset generated by plasma whole genome sequencing of cfDNA in a bodily fluid sample from the subject. The computing system may obtain a second sequencing dataset generated by whole genome sequencing of gDNA in a normal tissue from the subject. The computing system may perform phasing on the first sequencing dataset and the second sequencing dataset. Based on the phasing, the computing system may identify phase groups. Using the phase groups, the computing system may determine B allele frequency scores and/or fragment scores. Based on the scores, the computing system may select the subject for cancer therapy.
3.WO/2026/101912METHODS AND SYSTEMS FOR DETERMINING A PREGNANCY-RELATED STATE OF A SUBJECT
WO - 15.05.2026
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/US2025/053997 Applicant MIRVIE, INC. Inventor GEE, Elaine
The present disclosure provides methods and systems directed to cell-free identification and/or monitoring of pregnancy-related states. A method for identifying or monitoring a presence or elevated risk of a pregnancy-related state of a pregnant subject may comprise assaying a cell-free biological sample derived from said pregnant subject to detect a set of biomarkers, and analyzing the set of biomarkers with a trained algorithm to determine the presence or elevated risk of the pregnancy-related state.
4.WO/2026/102347MANUFACTURING AND PURIFICATION OF THERAPEUTIC MRNA
WO - 15.05.2026
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
 Appl.No PCT/US2025/054689 Applicant NATURE'S TOOLBOX, INC. Inventor YOWANTO, Handy
The invention includes a device for manufacturing mRNA by a continuous-flow recombinant process. The device comprises a housing; a cassette engaged with the housing, the cassette having a reaction chamber therein that holds an input reaction mixture having a DNA template wherein the manufacturing occurs within the cassette. The device has a thermal assembly providing a source of heat or cooling for the cassette, a pump to engage at least one tube within the cassette to control fluid flow through the cassette during manufacturing, a valve assembly to control a direction of fluid flow through the cassette, and a software application enabling a user to selectively manage operation of the device. The invention includes the cassette and the device as separate sub-combinations. The software application includes a non-transitory computer-readable medium containing computer executable instructions and a coupled computer processor or computer to execute the method of the manufacturing of mRNA.
5.WO/2026/102346SYSTEMS AND METHODS FOR HIGH THROUGHPUT APTAMER STRUCTURE CLASSIFICATION AND ASSESSMENT OF APTAMER STRUCTURE FUNCTIONALITY
WO - 15.05.2026
Int.Class G16B 15/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
15ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
10Nucleic acid folding
 Appl.No PCT/US2025/054687 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor CLIMACO, Paolo
Systems and methods are disclosed for high throughput classification and functionality assessment of aptamer structures. A non-limiting exemplary method includes: receiving, by a processor, a plurality of aptamer sequences; generating, by the processor, a structure for each aptamer sequence of the plurality of aptamer sequences to determine a plurality of structures; identifying, for each structure, a respective set of parameters assessing a similarity criteria between the structure and another structure of the plurality of structures; classifying, by applying the set of parameters of each structure into a machine learning model, the plurality of structures into one or more aptamer clusters; and determining a target binding characteristic for each aptamer of the one or more aptamer clusters.
6.WO/2026/099209A METHOD FOR COMPENSATING THE EFFECTS OF GAS CONTAMINATION FOR A VENOUS BLOOD SAMPLE
WO - 15.05.2026
Int.Class G16C 60/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
60Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
 Appl.No PCT/EP2025/081855 Applicant AALBORG UNIVERSITET Inventor REES, Stephen Edward
) together with the blood. The method has a mathematical model with physiological sub-models simulating development in blood together with this residual gas, including sub-models describing: 1) the diffusion of gasses between the residual gas and the blood sample, 2) the effects of the diffusing gas in the blood in the vacuum tube, and 3) the effects of the diffusing gas in the residual gas in the vacuum tube. The mathematical model then calculates a modified set of blood variables (BV) to compensate for the physical and/or chemical interactions between the residual gasses and the blood sample in the time following sampling and before blood gas measurement. By accounting for this contamination of the blood sample, calculation of the actual values of blood variables seen in the patient is possible.
7.WO/2026/098969TRAINING GENERATIVE MACHINE LEARNING MODELS ON MOLECULAR DYNAMICS SIMULATION DATA
WO - 15.05.2026
Int.Class G16C 20/70
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
CCOMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
20Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
70Machine learning, data mining or chemometrics
 Appl.No PCT/EP2025/080557 Applicant ISOMORPHIC LABS LIMITED Inventor WIRNSBERGER, Peter
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a generative machine learning model In one aspect, a method comprises: obtaining a set of training examples for training a generative machine learning model to perform a structure prediction task; augmenting the set of training examples to include a plurality of new training examples, comprising, for each training example in the set of training examples: performing a molecular dynamics simulation of a molecular system, starting from a conformation of the molecular system that is specified by the training example, to generate a trajectory of new conformations adopted by the molecular system over a duration of time; generating one or more new training examples corresponding to the molecular system; and training the generative machine learning model to perform the structure prediction task on the augmented set of training examples.
8.WO/2026/099134PHYSICS-BASED GUIDANCE FOR MOLECULAR STRUCTURE PREDICTION USING GENERATIVE DIFFUSION MODELS
WO - 15.05.2026
Int.Class G16B 15/30
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
15ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
30Drug targeting using structural data; Docking or binding prediction
 Appl.No PCT/EP2025/081712 Applicant ISOMORPHIC LABS LIMITED Inventor REDDY, Siddharth Gajjala
Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted 3D structure of a molecular system In one aspect, a method comprises using a generative diffusion model to generate the predicted 3D structure of the molecular system by denoising 3D structure data for the molecular system over a sequence of denoising iterations, comprising, at each of a plurality of denoising iterations: processing current structure data for the molecular system using a physics scoring model to generate a physics score that characterizes a degree to which the current structure data satisfies one or more physical constraints on the 3D structure of the molecular system; and generating a respective physics adjustment to the spatial position for each of the plurality of atoms based on the physics score.
9.WO/2026/099869DIGITAL THERAPEUTICS AND COMBINATION THERAPY FOR THE TREATMENT OF PARKINSON'S DISEASE
WO - 15.05.2026
Int.Class G16H 20/70
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
70relating to mental therapies, e.g. psychological therapy or autogenous training
 Appl.No PCT/IL2025/051003 Applicant REMEPY HEALTH LTD Inventor AMEDI, Amir
Provided is a method of digital therapeutics for modulating one or more Parkinson's disease-related markers, symptoms, or disease progression in an individual, on a standalone basis or by combining them with medicinal agents, particularly dopaminergic agents. Also provided are corresponding systems for implementing, delivering, and adapting such therapeutic interventions.
10.WO/2026/101398BARCODE FREE LIBRARY SCREEN
WO - 15.05.2026
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
 Appl.No PCT/NL2025/050557 Applicant UNIVERSITEIT LEIDEN Inventor POMPLUN, Sebastian Johannes
The present invention relates to a method for identifying which members of a barcode-free library of small molecules bind to a target and elucidating their molecular structure, the method comprising: a) mixing the members of at least one subset of the library with the target; b) separating the members that do not bind to the target (nonbinders) from the members that bind to the target (binders); c) analysing the binders using tandem mass spectrometry (MS/MS) to generate MS/MS spectra of the binders; and d) analysing the MS/MS spectra by computational analysis to elucidate the molecular structure of the binders.
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