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IC:G01N33/48

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Analysis

1 / 35,977
1.WO/2026/101517MULTIPLEXED ANALYTE SCREENING IN BIOLOGICAL SPATIAL ASSAYS
WO - 15.05.2026
Int.Class G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
 Appl.No PCT/US2024/054610 Applicant HANNINEN, Adam, M. Inventor HANNINEN, Adam, M.
spatial analysis of a sample, with particular applicability to biological materials, by strategically multiplexing a. plurality of different imaging techniques. For instance, certain inputs can be configured to elicit multiple different types of output signals from the sample simultaneously, each of which encodes a different attribute of the sample. These various outputs, once detected, decoded, and assembled, provide for a more- robust analysis than their individual techniques, i.e., if performed sequentially. As just one illustrative example, the infrared light involved in photothermal-infrared (PI) microscopy can also be used, to simultaneously trigger fluorescence-encoded infrared (FEIR) excitation within the sample. Pegging the excitation signals to specific biomarker targets can drastically enhance the combined 3D imagery' that results. Additional techniques may be integrated (i.e., higher-order multiplexing) to resolve the imagery even further.
2.WO/2026/101157BIOSENSOR SYSTEM FOR MONITORING EPOR DIMER FORMATION INDUCED BY LIGAND, AND TARGET LIGAND DETECTION METHOD USING SAME
WO - 15.05.2026
Int.Class G01N 33/74
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones
 Appl.No PCT/KR2025/017831 Applicant DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY Inventor LEE, Chang Hun
The present invention relates to a biosensor system for monitoring EPOR dimer formation by ligands and a target ligand detection method using same, wherein EPOR dimer formation by ligand binding can be rapidly and sensitively monitored using a fusion protein in which the EPOR ectodomain and a split fluorescent protein are fused. In addition, it is possible to monitor EPOR dimer formation by ligands and detect target ligands in vitro, and thus the complexity and duration of cell-based assays can be reduced, and high-speed screening can be easily applied. In addition, by measuring the reference fluorescence of a reference fluorescent protein together along with a signal fluorescence and comparing the reference fluorescence and signal fluorescence, accurate and quantitative analysis can be performed regardless of changes in measurement environment or variations in protein concentration.
3.WO/2026/098547ANTIBODY TARGETING CGRP AND USE THEREOF
WO - 15.05.2026
Int.Class C07K 16/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
26against hormones
 Appl.No PCT/CN2025/132978 Applicant HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC. Inventor QIN, Lingyun
An antibody targeting CGRP and the use thereof. The antibody or antigen-binding portion thereof comprises a heavy chain variable region and a light chain variable region. The heavy chain variable region comprises CDR-H1, CDR-H2 and CDR-H3. The light chain variable region comprises CDR-L1, CDR-L2 and CDR-L3. The antibody can specifically bind to human and rat CGRP polypeptides and α/β subtype CGRP polypeptides with high affinity, block the binding of CGRP to a receptor CGRPR thereof, reduce pain perception, and achieve the treatment of painful diseases such as migraines caused by CGRP. Additionally, the antibody can alleviate or treat hot flushes.
4.WO/2026/098577ANTI-CCR8 ANTIBODY OR ANTIGEN BINDING FRAGMENT THEREOF, AND USE THEREOF
WO - 15.05.2026
Int.Class C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
 Appl.No PCT/CN2025/133127 Applicant GUANGDONG FAPON BIOPHARMA INC. Inventor GUO, Jian
The present application relates to the technical field of biology, and discloses an anti-CCR8 antibody or an antigen binding fragment thereof, and a use thereof. The antibody can specifically bind to at least one epitope of CCR8, can also bind to Treg cells, has ADCC activity, and provides new possibilities for the treatment and/or prevention of cancer.
5.WO/2026/099626METHODS AND SYSTEMS FOR MANUFACTURING RADIOPHARMACEUTICALS
WO - 15.05.2026
Int.Class G01N 33/532
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
532Production of labelled immunochemicals
 Appl.No PCT/IB2025/000576 Applicant NOVARTIS AG Inventor BO, Michele
The presently disclosed subject matter relates to methods for manufacturing radiopharmaceuticals and systems for implementing such methods.
6.WO/2026/101156GENE CASSETTE FOR BIOSENSOR EXPRESSION, METHOD FOR CONSTRUCTING SAME, AND METHOD FOR DETECTING TARGET LIGAND USING SAME
WO - 15.05.2026
Int.Class G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
 Appl.No PCT/KR2025/017826 Applicant DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY Inventor LEE, Chang Hun
The present invention relates to a gene cassette expressing a fusion protein, a method for constructing same, and a method for detecting a target ligand, using same. When a target ligand binds to a target receptor ectodomain to form a dimer, a fused split fluorescent protein fragment is assembled to generate a fluorescence signal, thereby enabling rapid and simple monitoring of the presence or absence of the target ligand.
7.WO/2026/099752METHOD FOR PROCESSING A BIOLOGICAL SAMPLE AND DEVICE THEREFOR
WO - 15.05.2026
Int.Class B01L 3/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
 Appl.No PCT/IB2025/061289 Applicant BECKMAN COULTER, INC. Inventor NAETZER, Beate C.
A first aspect of the present disclosure is related to a method for processing a biological sample with an automated laboratory system, comprising the steps: - loading a primary tube containing a primary biological sample comprising a pre-defined agent, e.g. Platelets; - performing a centrifugation of the primary biological sample; - transferring at least a part of the primary biological sample as a secondary biological sample into a secondary tube; - performing a centrifugation of the secondary biological sample; - providing a sample based on the centrifuged secondary biological sample.
8.WO/2026/102317AUTOMATED ASSAY PROCESSING UNIT
WO - 15.05.2026
Int.Class G01N 35/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
02using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
 Appl.No PCT/US2025/054642 Applicant ABBOTT LABORATORIES Inventor HARRIS, Jason N.
The present disclosure provides automated assay processing units comprising a plurality of components for processing a sample and analyzing the components of the sample when the sample is present in a consumable. The present disclose also provides automated assay processing units for processing large numbers of consumables simultaneously.
9.WO/2026/102346SYSTEMS AND METHODS FOR HIGH THROUGHPUT APTAMER STRUCTURE CLASSIFICATION AND ASSESSMENT OF APTAMER STRUCTURE FUNCTIONALITY
WO - 15.05.2026
Int.Class G16B 15/10
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
15ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
10Nucleic acid folding
 Appl.No PCT/US2025/054687 Applicant THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Inventor CLIMACO, Paolo
Systems and methods are disclosed for high throughput classification and functionality assessment of aptamer structures. A non-limiting exemplary method includes: receiving, by a processor, a plurality of aptamer sequences; generating, by the processor, a structure for each aptamer sequence of the plurality of aptamer sequences to determine a plurality of structures; identifying, for each structure, a respective set of parameters assessing a similarity criteria between the structure and another structure of the plurality of structures; classifying, by applying the set of parameters of each structure into a machine learning model, the plurality of structures into one or more aptamer clusters; and determining a target binding characteristic for each aptamer of the one or more aptamer clusters.
10.WO/2026/101236PEPTIDES SPECIFICALLY BINDING TO CCR8, AND USE THEREOF
WO - 15.05.2026
Int.Class C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
 Appl.No PCT/KR2025/018079 Applicant UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY Inventor BAE, Hyunsu
The present invention relates to a peptide, an antibody or an immunologically active fragment thereof, each specifically binding to CCR8, and a use thereof. It has been identified that CCR8-binding peptides newly discovered in the present invention bind to the TM sub-pocket of CCR8 in a pattern similar to that of CCL1, and actually specifically bind to cells having CCR8 expressed in the cell membrane thereof, and thus the proteins can be used as target materials for drug design targeting Tregs in which CCR8 is expressed and, when used, cytotoxic drugs can be specifically delivered to a tumor microenvironment or cancer cells without affecting other effector T cells or peripheral Tregs, and thus side effects of a conventional cancer immunotherapy agent can be reduced.
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