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Analysis

1 / 24,197
1.WO/2026/102087QUANTIFICATION OF TARGETS USING CYCLE-BY-CYCLE DATA COLLECTED ON A DIGITAL POLYMERASE CHAIN REACTION PLATFORM
WO - 15.05.2026
Int.Class C12Q 1/6851
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6851Quantitative amplification
 Appl.No PCT/US2025/054304 Applicant LIFE TECHNOLOGIES CORPORATION Inventor LEONG, Harrison
A method for quantification of a target molecule of a biological sample distributed across a plurality of partitions is provided. The method includes receiving fluorescent emission data generated by a polymerase chain reaction (PCR) for each partition of a set of partitions and identifying a partition quantity metric for each partition in the set of partitions to generate a set of partition quality metrics. Each partition quantity metric correlates to a number of target molecules within its respective partition based on the fluorescent emission data. The set of partition quantity metrics is used to determine a state of target molecule amplification within each partition of the set of partitions. The method further includes determining a quantity of the target molecule in the biological sample based on the set of partition quantity metrics.
2.WO/2026/102132METHODS FOR DETECTION OF CANCER ANEUPLOIDY AND SELECTION OF SUBJECTS FOR ANTI-CANCER THERAPY THROUGH PLASMA WHOLE GENOME SEQUENCING
WO - 15.05.2026
Int.Class C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
 Appl.No PCT/US2025/054384 Applicant MEMORIAL SLOAN-KETTERING CANCER CENTER Inventor WIDMAN, Adam
Presented herein are systems and methods for selecting a subject for a cancer therapy based on detection of allelic imbalances in cell-free deoxyribonucleic acid (cfDNA) in a bodily fluid sample of the subject. A computing system may obtain, for a subject at risk of or diagnosed with cancer, a first sequencing dataset generated by plasma whole genome sequencing of cfDNA in a bodily fluid sample from the subject. The computing system may obtain a second sequencing dataset generated by whole genome sequencing of gDNA in a normal tissue from the subject. The computing system may perform phasing on the first sequencing dataset and the second sequencing dataset. Based on the phasing, the computing system may identify phase groups. Using the phase groups, the computing system may determine B allele frequency scores and/or fragment scores. Based on the scores, the computing system may select the subject for cancer therapy.
3.WO/2026/102342BIOLOGICAL BASED WIRING OF ELECTRONIC CIRCUITS FOR MOLECULAR SENSING APPLICATIONS
WO - 15.05.2026
Int.Class C12Q 1/6825
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
6825Nucleic acid detection involving sensors
 Appl.No PCT/US2025/054680 Applicant ATLAS DATA STORAGE, INC. Inventor BOWEN, Michael Shane
In some embodiments, an apparatus comprises a first electrode and a second electrode defining a gap therebetween; a molecular wire disposed across the gap, and configured to electrically connect the first electrode and the second electrode, the molecular wire including: at least one molecule of deoxyribonucleic acid (DNA) including a double stranded portion; and a plurality of functional groups coupled to nucleotides of the at least one molecule of DNA at predetermined positions along the at least one molecule of DNA, the plurality of functional groups configured to cause electron delocalization along the molecular wire to increase an electrical conductivity of the molecular wire; and a first molecular linker configured to couple a first portion of the molecular wire to the first electrode and a second molecular linker configured to couple a second portion of the molecular wire to the second electrode.
4.WO/2026/102372GENOMIC DNA AMPLIFICATION AND BARCODING
WO - 15.05.2026
Int.Class C12Q 1/6855
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
6853using modified primers or templates
6855Ligating adaptors
 Appl.No PCT/US2025/054759 Applicant ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY Inventor GEILER-SAMEROTTE, Kerry
. In the first step of amplification, primers are employed that that bind a target sequence; and post-amplification, a barcoded primer is ligated onto the newly amplified double-stranded DNA, the barcoded primer having a free end that allows the attachment of additional barcodes. This strategy provides for improved amplification efficiency over methods previously used in the art.
5.WO/2026/099507NOVEL MARKERS FOR THE VERIFICATION OF A RELIABLE BIOLOGICAL SAMPLE AND USES THEREOF
WO - 15.05.2026
Int.Class C12Q 1/6881
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6881for tissue or cell typing, e.g. human leukocyte antigen probes
 Appl.No PCT/EP2025/082625 Applicant RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN Inventor GÜTGEMANN, Ines
. Also provided is the use of the novel markers of the invention for verifying the reliability of a biological sample. Furthermore, provided are methods for screening of sexually transmitted infections (STI) and of dysplastic / neoplastic lesions in a biological sample. The present invention also provides a kit of parts for the above-mentioned methods.
6.WO/2026/100122PCR METHOD, PCR DEVICE, AND PCR KIT
WO - 15.05.2026
Int.Class C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
 Appl.No PCT/JP2025/020638 Applicant HITACHI, LTD. Inventor KAMURA, Yoshio
.
7.WO/2026/102281ON-FLOW CELL LIBRARY PREPARATION FOR SINGLE-CELL RNA ANALYSIS
WO - 15.05.2026
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
 Appl.No PCT/US2025/054600 Applicant ILLUMINA, INC. Inventor BOMBARDI, Robin
Methods for characterizing analytes present in a sample of individual cells. The initial sample processing steps take place on a per-cell basis within an individual partition (e.g., droplet) to tag or barcode each cell with a cell-specific barcode (e.g. using capture probe with cell barcode bound to bead). Subsequent sample processing steps take place on a flow cell surface with transposase to generate location-specific information that serves to link individual sequences reads with one another based on intrinsic molecular identifiers, adjacent fragmenting and cluster formation. The disclosed workflow generates expression-level data (based on read count) as well as linked read data to facilitate genome or full transcript assembly.
8.WO/2026/101912METHODS AND SYSTEMS FOR DETERMINING A PREGNANCY-RELATED STATE OF A SUBJECT
WO - 15.05.2026
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/US2025/053997 Applicant MIRVIE, INC. Inventor GEE, Elaine
The present disclosure provides methods and systems directed to cell-free identification and/or monitoring of pregnancy-related states. A method for identifying or monitoring a presence or elevated risk of a pregnancy-related state of a pregnant subject may comprise assaying a cell-free biological sample derived from said pregnant subject to detect a set of biomarkers, and analyzing the set of biomarkers with a trained algorithm to determine the presence or elevated risk of the pregnancy-related state.
9.WO/2026/102107METHODS FOR DETECTING SOMATIC VARIANTS
WO - 15.05.2026
Int.Class C12Q 1/6806
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction assay
 Appl.No PCT/US2025/054338 Applicant GUARDANT HEALTH, INC. Inventor KENNEDY, Andrew
The disclosure relates to methods for detecting somatic variants in the DNA of a subject having or suspected of having a disease or disorder, such as cancer. In some embodiments, the methods of the present disclosure comprise obtaining three DNA samples from a subject and identifying a subset of somatic variants that are detectable in the first sample and not detectable in the second sample and determining the presence or absence of at least a portion of the subset of somatic variants in the third sample. In some embodiments the presence or absence of the portion of the subset of somatic variants in the third sample is used to determine the presence of minimum residual disease.
10.WO/2026/102332NERVE AND TUMOR HOMING AGENTS AND METHODS OF USE THEREOF
WO - 15.05.2026
Int.Class C12Q 1/6881
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6881for tissue or cell typing, e.g. human leukocyte antigen probes
 Appl.No PCT/US2025/054665 Applicant BLAZE BIOSCIENCE, INC. Inventor BARTH, Connor
Disclosed herein a method of visualizing and treating a cancer in a subject in need thereof, the method comprising: administering to the subject a tumor homing agent and a nerve homing agent. The technology described herein provides direct visualization of tissue, cells, and margins and direct visualization of nerves simultaneously in surgical settings and pathology samples in order to improve surgical outcomes in cancer surgeries and reduce comorbidities for patients.
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