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Analysis

1 / 24,746
1.WO/2026/098772SINGLE-POT IN VITRO TRANSCRIPTION OF SYNTHETIC CAPPED MRNA
WO - 15.05.2026
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No PCT/EP2024/081344 Applicant ANEMOCYTE S.R.L. Inventor PUPO, Marco
The present invention concerns the field of optimized mRNA synthesis and stability. Specifically, the invention relates to a method and kit for a single-pot in vitro transcription of synthetic capped mRNA.
2.WO/2026/098696PRODUCTION METHOD FOR PROTEASE AND USE THEREOF
WO - 15.05.2026
Int.Class C12N 9/50
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
 Appl.No PCT/CN2025/133975 Applicant NANJING BESTZYME BIO-ENGINEERING CO., LTD. Inventor BIAN, Furong
The present invention provides an improved production method for high-temperature protease and use thereof. In the present invention, a pfuS high-temperature protease propeptide is fused with a Tn high-temperature protease mature peptide to produce a Tn high-temperature protease. Compared to a wild-type Tn high-temperature protease, the Tn high-temperature protease produced in the form of a fusion polypeptide results in a significant increase in yield. Introducing point mutations into the pfuS high-temperature protease propeptide can further improve the yield of the Tn high-temperature protease.
3.WO/2026/099341BIOCONTAINMENT OF UNWANTED ENGINEERED CELLS USING NON-NATURAL AMINO ACIDS
WO - 15.05.2026
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
 Appl.No PCT/EP2025/082101 Applicant SNIPR BIOME APS Inventor SEMSEY, Szabolcs
The technology described herein relates to new nuclease and nickase fusions of new CRISPR/Cas systems and their use as a biocontainment kill-switch in modified and/or engineered bacteria.
4.WO/2026/099311MICROBIAL CELL FACTORIES PRODUCING PROSTAGLANDINS
WO - 15.05.2026
Int.Class C12N 15/52
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
 Appl.No PCT/EP2025/082050 Applicant RIVER STONE BIOTECH APS Inventor FROST, Emma Thinggaard
The present disclosure relates to genetically modified host cells producing prostaglandins, to genetic constructs for expression of such mutants; to cultures of the genetically modified host cells and its use to produce the said products; to fermentation liquids comprising the said products resulting from such production; to compositions comprising the fermentation liquid; to pharmaceutical preparations made from such compositions and to the uses of such compositions and preparations.
5.WO/2026/099566INSECT REPELLENT
WO - 15.05.2026
Int.Class C12P 7/26
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
24containing a carbonyl group
26Ketones
 Appl.No PCT/GB2025/052399 Applicant THE UNIVERSITY OF YORK Inventor SMIT, Samuel Jacobus
This disclosure concerns a method for the conversion of nepetalactol and/or nepetalactone to dihydronepetalactone catalysed by nepetalactol-related short-chain dehydrogenase enzymes (NEPS) polypeptides from Nepeta mussinii (Nepeta racemosa) and modified NEPS polypeptides with increased activity; and including microbial cells, plant cells and plants transformed to express said modified NEPS polypeptides
6.WO/2026/097616METHOD FOR ACQUIRING CHLAMYDOMONAS REINHARDTII SOURCE RECOMBINANT HIRUDIN ALGAE POWDER BY MEANS OF FERMENTATION CULTURE METHOD
WO - 15.05.2026
Int.Class C12N 1/12
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
12Unicellular algae; Culture media therefor
 Appl.No PCT/CN2024/133289 Applicant WUHAN YUANQI HE SHENG TECHNOLOGIAE SOCIETAS LIMITATA Inventor FENG, Li
The present invention relates to the field of fermentation production. Provided is a method for acquiring chlamydomonas reinhardtii source recombinant hirudin algae powder by means of a fermentation culture method. The method can effectively multiply the algae source recombinant hirudin.
7.WO/2026/101912METHODS AND SYSTEMS FOR DETERMINING A PREGNANCY-RELATED STATE OF A SUBJECT
WO - 15.05.2026
Int.Class C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
 Appl.No PCT/US2025/053997 Applicant MIRVIE, INC. Inventor GEE, Elaine
The present disclosure provides methods and systems directed to cell-free identification and/or monitoring of pregnancy-related states. A method for identifying or monitoring a presence or elevated risk of a pregnancy-related state of a pregnant subject may comprise assaying a cell-free biological sample derived from said pregnant subject to detect a set of biomarkers, and analyzing the set of biomarkers with a trained algorithm to determine the presence or elevated risk of the pregnancy-related state.
8.WO/2026/098687METHOD FOR PREPARING LONG DOUBLE-STRANDED NUCLEIC ACID
WO - 15.05.2026
Int.Class C12N 15/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
 Appl.No PCT/CN2025/133887 Applicant CODER THERAPEUTICS CO., LTD Inventor XIA, Ninuo
The present invention relates to a method for preparing a long double-stranded nucleic acid. The present invention relates to a method for synthesizing a long double-stranded nucleic acid from a short single-stranded nucleic acid. The method is characterized by the presence of an intermediate, and the intermediate refers to a long double-stranded nucleic acid with a nick. In addition, the present invention further relates to use of the method in the synthesis of a long double-stranded nucleic acid.
9.WO/2026/099917METHOD FOR PRODUCING USEFUL SUBSTANCE, CULTURE SOLUTION FOR CULTURING ALGAE, AND DEVICE FOR PRODUCING USEFUL SUBSTANCE
WO - 15.05.2026
Int.Class C12P 23/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
23Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
 Appl.No PCT/JP2024/039245 Applicant NTT, INC. Inventor IMAMURA Sousuke
The present disclosure provides a method for producing a useful substance, the method comprising: a step for providing an algae culture by culturing algae in a culture solution containing a phosphoenzyme inhibitor; and a step for isolating a useful substance contained in the algae culture.
10.WO/2026/099317TRANSCRIPTION OF SYNTHETIC CAPPED MRNA
WO - 15.05.2026
Int.Class C12P 19/34
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
 Appl.No PCT/EP2025/082057 Applicant ANEMOCYTE S.R.L. Inventor PUPO, Marco
The present invention concerns the field of optimized mRNA synthesis and stability. Specifically, the invention relates to a method and kit for a single-pot in vitro transcription of synthetic capped mRNA.
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