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IC:C07D

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Analysis

1 / 73,356
1.WO/2026/102147TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS
WO - 15.05.2026
Int.Class C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
 Appl.No PCT/US2025/054404 Applicant TREELINE BIOSCIENCES, INC. Inventor HORN, Evan J.
protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions comprising the compounds of Formula (I), (II), (III), (IV), (V), or (VI), or pharmaceutically acceptable salts thereof, provided herein as well as methods of using and making the same.
2.WO/2026/099687CROSS-LINKABLE ELASTOMERIC COMPOSITION AND TIRE
WO - 15.05.2026
Int.Class C07D 309/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
309Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
34having three or more double bonds between ring members or between ring members and non-ring members
36with oxygen atoms directly attached to ring carbon atoms
40Oxygen atoms attached in positions 3 and 4, e.g. maltol
 Appl.No PCT/IB2025/060918 Applicant PIRELLI TYRE S.P.A. Inventor GIANNINI, Luca
This invention relates to: a cross-linkable elastomeric composition comprising an unsaturated heterocyclic compound; a process for preparing an elastomeric compound; a tire component comprising the aforementioned elastomeric compound; and a tire for vehicle wheels comprising at least the aforementioned tire component.
3.WO/2026/099897NOVEL LINKERS AND ITS PREPARATION METHODS THEREOF
WO - 15.05.2026
Int.Class C07D 207/452
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
44having three double bonds between ring members or between ring members and non-ring members
444having two doubly-bound oxygen atoms directly attached in positions 2 and 5
448with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
452with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
 Appl.No PCT/IN2025/051760 Applicant ZYDUS LIFESCIENCES LIMITED Inventor IYER, Pravin
The present invention relates to a novel linker for Antibody-drug conjugates (ADCs), Peptide- drug conjugates (PDCs) and a preparation method for it, wherein the linker's one end can selectively and covalently link a targeting substance, and its other end can covalently link to a small molecule compound or a cytotoxic payload. The linkers of the present invention can be used to prepare an antibody drug conjugate, and it can be used for various applications including anticancer activity and other medicinal uses.
4.WO/2026/098592USE OF HETEROCYCLIC COMPOUND AND COMPLEX FORMED BY HETEROCYCLIC COMPOUND AND PHARMACEUTICALLY ACCEPTABLE ACID
WO - 15.05.2026
Int.Class A61K 31/4375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
 Appl.No PCT/CN2025/133217 Applicant HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC. Inventor ZHANG, Xuejun
The present invention relates to use of a heterocyclic compound and a complex formed by the heterocyclic compound and a pharmaceutically acceptable acid. Specifically, provided is use of a compound represented by formula (I-3B) or a complex thereof in the preparation of a drug for treating and/or preventing inflammatory bowel diseases. The complex is a complex formed by the compound represented by formula I-3B and a pharmaceutically acceptable acid. The compound represented by formula I-3B or the complex thereof can significantly mitigate IBD symptoms and tissue injury, and possesses good safety.
5.WO/2026/098607F-18 LABELED AQUEOUS PHARMACEUTICAL COMPOSITION TARGETING LIGAND OF FIBROBLAST ACTIVATION PROTEIN, AND PREPARATION METHOD THEREFOR
WO - 15.05.2026
Int.Class A61K 51/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
 Appl.No PCT/CN2025/133289 Applicant TIANJIN HENGRUI MEDICINE CO., LTD. Inventor HAN, Jian
The present invention relates to an F-18 labeled aqueous pharmaceutical composition targeting a ligand of a fibroblast activation protein, and a preparation method therefor. Specifically, the present invention relates to an aqueous pharmaceutical composition of a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The aqueous pharmaceutical composition possesses a high radiochemical purity.
6.WO/2026/098637TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
WO - 15.05.2026
Int.Class C07D 498/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
 Appl.No PCT/CN2025/133434 Applicant JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. Inventor ZHANG, Zhigao
The present disclosure relates to a tricyclic compound, and a preparation method therefor and a pharmaceutical use thereof. Specifically, the present disclosure relates to a tricyclic compound as shown in general formula (I), a preparation method therefor, a pharmaceutical composition containing the tricyclic compound, and a use thereof as a therapeutic agent, especially a use as a VAV1 inhibitor or degradation agent, and a use in preparation of drugs for treating and/or preventing VAV1 mediated or dependent diseases or disorders. The groups in general formula (I) are as defined in the description.
7.WO/2026/098667USP30 INHIBITOR COMPOUND, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF
WO - 15.05.2026
Int.Class C07D 487/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
 Appl.No PCT/CN2025/133716 Applicant CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD. Inventor YANG, Zimo
The present invention provides a compound having USP30 inhibitor activity, a use thereof, a preparation method therefor, and a composition containing the inhibitor. These inhibitors are useful in a variety of therapeutic fields, including diseases or conditions involving mitochondrial dysfunction, such as PD, cancer, and fibrosis.
8.WO/2026/102326PYRIDAZINONE COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUSCULAR CONDITIONS
WO - 15.05.2026
Int.Class C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
 Appl.No PCT/US2025/054654 Applicant EDGEWISE THERAPEUTICS, INC. Inventor SCHLACHTER, Stephen, Thomas
Treatments of neuromuscular conditions, activity-induced muscle damage, metabolic myopathies, and movement disorders with compositions comprising 2-((5-fluoropyridin-3-yl)methyl)-6-(2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)pyridazin-3(2H)-one (Compound 1), as well as solid forms of Compound 1, and pharmaceutical compositions of Compound 1, and kits of Compound 1, are described herein.
9.WO/2026/099776A PROCESS FOR THE PREPARATION OF PACLITAXEL
WO - 15.05.2026
Int.Class C07D 305/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
 Appl.No PCT/IB2025/061338 Applicant FRESENIUS KABI ONCOLOGY LTD. Inventor MITRA, Joydeb
The present invention relates to an improved process for the preparation of Paclitaxel. More particularly, the invention provides a green synthetic process for preparation of Paclitaxel from 10-Deacetybaccatin-III (10-DAB), wherein the reactions at various stages does not involve the use of hazardous solvents and reagents or any tedious purification techniques. The present invention also provides Paclitaxel and its intermediates in high yield and purity, eliminating the use of inorganic salts in work-up, thus making the isolation process for the intermediates and product easy.
10.WO/2026/101411PROCESS, PLANT AND REACTOR FOR PRODUCING 3-METHYLSULFOLENE
WO - 15.05.2026
Int.Class C07B 45/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
45Formation or introduction of functional groups containing sulfur
04of sulfonyl or sulfinyl groups
 Appl.No PCT/RU2025/000320 Applicant MNUSHKIN, Igor' Anatol`evich Inventor MNUSHKIN, Igor' Anatol`evich
The invention is directed toward the production of 3-methylsulfolene using isoprene and can be used in the chemical and petrochemical industry. A process of producing 3-methylsulfolene using isoprene comprises reacting isoprene with sulfur dioxide in a cyclization reaction in the presence of an isoprene polymerization inhibitor and a tenfold excess of solvent relative to the amount of 3-methylsulfolene produced, at a temperature of 60-80°C and a pressure of 1.0 MPa for 1-2 hours, and subsequently purifying and drying the 3-methylsulfolene. The process is carried out in a plant for producing 3-methylsulfolene which consists of a batch reaction apparatus having an agitator and a heat exchange jacket, a fractionating column, pumps, feedstock tanks, final product tanks, intermediate tanks, a sulfur oxidation unit, a filter unit, and a unit of heat exchangers that are interconnected by a system of pipes with shutoff valves. The process of producing 3-methylsulfolene provides a high yield of high-purity target product, prevents large losses of solvent and enables more efficient use of sulfur, and can be used for industrial-scale production with the aid of the proposed plant, which provides for efficient production of 3-methylsulfolene.
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