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1 / 26,426
1.WO/2026/102252COMPOSITION AND METHOD FOR MODULATING MICROBIOMES WITH POSTBIOTIC FERMENTS
WO - 15.05.2026
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
 Appl.No PCT/US2025/054563 Applicant KIMBERLY-CLARK WORLDWIDE, INC. Inventor QUIRK, Stephen
spp. bacteria to prevent dysbiosis and other related conditions and infections.
2.WO/2026/102462ENGINEERED CELLS FOR TREATING DIABETES
WO - 15.05.2026
Int.Class A61K 35/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
 Appl.No PCT/US2025/055010 Applicant CITY OF HOPE Inventor YEE, Jiing-Kuan
, genetically engineered human pluripotent stem cells, beta cells derived from genetically engineered human pluripotent stem cells, compositions, and cell aggregates, and methods of treating diabetes. The human pluripotent stem cells and beta cells provided herein including embodiments thereof may be genetically modified to express exogenous genes and/or inactivate endogenous genes.
3.WO/2026/097827SWARMING-MOTILITY ENTEROBACTER LUDWIGII AND USE THEREOF
WO - 15.05.2026
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
 Appl.No PCT/CN2025/096776 Applicant SHANGHAI LISHAN BIOPHARMACEUTICAL CO., LTD. Inventor CHEN, Weijie
Provided are an Enterobacter ludwigii strain and use thereof in the amelioration of inflammatory bowel disease. The present invention belongs to the technical field of new applications of microorganisms. The strain is named Enterobacter ludwigii LS-57 and is deposited in China General Microbiological Culture Collection Center under the accession number CGMCC NO. 31424, with a deposit date of July 22, 2024. The strain exhibits swarming motility, has relatively strong adaptability to the intestinal environment, tolerates gastric juice acidity well, is sensitive to various commonly used antibiotics, and has a good ameliorative effect on colitis.
4.WO/2026/097722CHONDROGENIC STEM CELL FOR PROMOTING JOINT REPAIR AND USE THEREOF
WO - 15.05.2026
Int.Class A61K 35/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
 Appl.No PCT/CN2025/077520 Applicant TONGJI UNIVERSITY Inventor YUE, Rui
Provided are a chondrogenic stem cell for promoting joint repair and use thereof. Specifically, disclosed is a cell preparation used for alleviating or treating osteoarthritis, comprising a Procr-positive pluripotent stem cell. The Procr-positive chondrogenic stem cell can differentiate and generate downstream chondrocytes in vivo and promote cartilage repair in osteoarthritis damage, which will be a more effective cell treatment method. In addition, Procr proteins can be used as a new target of a drug for treating osteoarthritis.
5.WO/2026/097871LIMOSILACTOBACILLUS REUTERI SUBSP. REUTERI LR1349, AND COMPOSITION INCLUDING THE SAME AND USE THEREOF
WO - 15.05.2026
Int.Class C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
 Appl.No PCT/CN2025/101757 Applicant SYNBIO TECH INC. Inventor WU, Chi-Hao
Limosilactobacillus reuteri subsp. reuteri LR1349 is deposited at the Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ) GmbH under an accession number DSM 35135 in accordance with the Budapest Treaty. A method for alleviating blue light-induced retinal damage using the same, a composition for use in alleviation of blue light-induced retinal damage, use of a composition in the manufacture of a medication or a food product in alleviation of blue light-induced retinal damage in a subject, and a pharmaceutical composition for alleviation of blue light-induced retinal damage are also provided.
6.WO/2026/099467COMPOSITION FOR USE IN PROMOTING BRAIN DEVELOPMENT AND FUNCTIONING
WO - 15.05.2026
Int.Class A61K 35/745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
 Appl.No PCT/EP2025/082362 Applicant SOCIÉTÉ DES PRODUITS NESTLÉ S.A. Inventor MEISSER REDEUIL, Karine
The present invention relates to compositions comprising Bifidobacterium longum subsp. iuvenis in an effective amount for use in increasing production of at least one polyamine and/or its metabolite, and/or gamma-aminobutyric acid (GABA), by the gut microbiota of a young individual to promote brain development and/or brain functioning in a young individual.
7.WO/2026/099721METHOD FOR BACTERIOPHAGE PRODUCTION
WO - 15.05.2026
Int.Class C12N 7/02
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
02Recovery or purification
 Appl.No PCT/IB2025/061198 Applicant NATIONAL RESEARCH COUNCIL OF CANADA Inventor PETERS, Danielle
Provided is a method for infecting a bacterium, in which a host bacterium is exposed to a phage depolymerase and a bacteriophage. The depolymerase catalyzes degradation of at least one cell-surface or extracellular polysaccharide of the host bacterium, thereby increasing the susceptibility of the host bacterium to infection by the bacteriophage. The method may be used to increase production of the bacteriophage and/or to increase the host range of the bacteriophage. Further provided is use of a phage depolymerase selected from B5, As11, TaPaz, APK2, APK37, and IME200, or a composition comprising the same, for increasing the susceptibility of an A. baumannii to infection by a bacteriophage. The A. baumannii may be an AB030, MRSN 843, MRSN 1183, MRSN 7446, MRSN 15088, MRSN 24008, MRSN 31159, MRSN 31468, or MRSN 32866 strain.
8.WO/2026/101986IRRADIATED EXTRACELLULAR VESICLES AND METHODS OF MAKING AND USING SAME
WO - 15.05.2026
Int.Class A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
 Appl.No PCT/US2025/054138 Applicant HENRY FORD HEALTH SYSTEM Inventor ZHANG, Zheng-Gang
(Lacto). The cancer may be ovarian cancer, colon cancer, prostate cancer, lung cancer, breast cancer, colorectal cancer, brain cancer, hepatocellular carcinoma, or pancreatic cancer. Results herein show in particular that red-light irradiated Lacto-EVs can robustly amplify immunotherapy efficacy in cancer.
9.WO/2026/101295LACTIC ACID BACTERIA COMPOSITION FOR TREATING NOSEMOSIS
WO - 15.05.2026
Int.Class A61K 35/747
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
747Lactobacilli, e.g. L. acidophilus or L. brevis
 Appl.No PCT/KR2025/018224 Applicant REPUBLIC OF KOREA(ANIMAL AND PLANT QUARANTINE AGENCY) Inventor YOUN, So Youn
The present invention relates to lactic acid bacteria strains effective in protecting against honeybee nosemosis and, specifically, to probiotics of a combination of six strains of lactic acid bacteria in the intestines of honeybees, the probiotics exhibiting a therapeutic effect on nosemosis associated with honeybee diarrhea and post-overwintering mass mortality. When the composition of the present invention is used, nosemosis can be effectively prevented or inhibited.
10.WO/2026/097245CRYOPROTECTANT AND USE THEREOF
WO - 15.05.2026
Int.Class C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
 Appl.No PCT/CN2024/130128 Applicant SUZHOU ROCROCK NO.1 BIOTECHNOLOGY CO., LTD. Inventor YIN, Xiushan
, and 1-10 wt % of a zwitterionic donor, wherein the mass percentage is the mass percentage in the cryoprotectant, and the concentration of the pH buffer in the cryoprotectant is greater than 0 and less than or equal to 100 mM.
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