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1. (US20170286619) Method and system for microbiome-derived diagnostics and therapeutics

Office : United States of America
Application Number: 15621144 Application Date: 13.06.2017
Publication Number: 20170286619 Publication Date: 05.10.2017
Grant Number: 10289805 Grant Date: 14.05.2019
Publication Kind : B2
IPC:
G01N 33/48
G06F 19/00
G16B 50/00
C12Q 1/68
C12Q 1/6883
C12Q 1/689
G16H 50/20
G16H 20/10
G16B 99/00
G16B 5/00
G06G 7/58
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
[IPC code unknown for G16B 50]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
[IPC code unknown for C12Q 1/6883][IPC code unknown for C12Q 1/689][IPC code unknown for G16H 50/20][IPC code unknown for G16H 20/10][IPC code unknown for G16B 99][IPC code unknown for G16B 5]
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
G
ANALOGUE COMPUTERS
7
Devices in which the computing operation is performed by varying electric or magnetic quantities
48
Analogue computers for specific processes, systems, or devices, e.g. simulators
58
for chemical processes
CPC:
C12Q 1/68
C12Q 1/6883
C12Q 1/689
C12Q 2600/118
G06F 19/30
G06F 19/3418
G16B 5/00
G16B 50/00
G16B 99/00
G16H 20/10
G16H 50/20
Y02A 90/26
Applicants: uBiome, Inc.
Inventors: Zachary Apte
Jessica Richman
Daniel Almonacid
Agents: Kilpatrick Townsend & Stockton LLP
Priority Data:
Title: (EN) Method and system for microbiome-derived diagnostics and therapeutics
Abstract: front page image
(EN)

A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.