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1. US20160367911 - Determination of chromatography conditions

Office United States of America
Application Number 15173215
Application Date 03.06.2016
Publication Number 20160367911
Publication Date 22.12.2016
Grant Number 10376813
Grant Date 13.08.2019
Publication Kind B2
IPC
B01D 15/36
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/16
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
16relating to the conditioning of the fluid carrier
B01D 15/34
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
34Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
B01D 15/42
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
42characterised by the development mode, e.g. by displacement or by elution
CPC
B01D 15/166
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
10characterised by constructional or operational features
16relating to the conditioning of the fluid carrier
166Fluid composition conditioning, e.g. gradient
B01D 15/362
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
36involving ionic interaction
361Ion-exchange
362Cation-exchange
B01D 15/34
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
26characterised by the separation mechanism
34Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
B01D 15/424
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents
08Selective adsorption, e.g. chromatography
42characterised by the development mode, e.g. by displacement or by elution
424Elution mode
Applicants GE Healthcare Bio-Sciences AB
Inventors Enrique Napoleon Carredano
Gustav Jose Rodrigo
Agents Wood IP LLC
Priority Data 201510477 16.06.2015 GB
Title
(EN) Determination of chromatography conditions
Abstract
(EN)

The present invention relates to a method for the determination of chromatography conditions for the separation of a biomolecule from a liquid sample, which method comprises selecting a number of experiments using design of experiments (DoE); performing said experiments with in-line conditioning of orthogonal quality measures; and based on the results from the experiments, determining efficient chromatography conditions for said biomolecule.

The invention also relates to a system for performing the method as well as a computer program and an instrument comprising such a computer program.

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