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1. US20060094119 - Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems

Office United States of America
Application Number 11082187
Application Date 16.03.2005
Publication Number 20060094119
Publication Date 04.05.2006
Grant Number 7655470
Grant Date 02.02.2010
Publication Kind B2
IPC
G01N 35/08
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
08using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
CPC
B01F 13/0071
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
0069the components flowing in the form of droplets
0071the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
B01L 3/06
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
06Crystallising dishes
B01L 3/502723
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502723characterised by venting arrangements
B01L 3/502784
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502769characterised by multiphase flow arrangements
502784specially adapted for droplet or plug flow, e.g. digital microfluidics
B01L 3/527
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
52Containers specially adapted for storing or dispensing a reagent
527for a plurality of reagents
B01L 2200/0673
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0673Handling of plugs of fluid surrounded by immiscible fluid
Applicants University of Chicago
Inventors Ismagilov Rustem F.
Zheng Bo
Gerdts Cory J.
Agents Brinks Hofer Gilson &; Lione
Title
(EN) Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
Abstract
(EN)

The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.