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1. PE20010054 - PIRAZOLBENZODIAZEPINAS COMO INHIBIDORES DE QUINASAS DEPENDIENTES DE CICLINA

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Office Peru
Application Number 2000000370
Application Date 19.04.2000
Publication Number 20010054
Publication Date 07.02.2001
Publication Kind A1
IPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 243/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
243Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
06having the nitrogen atoms in positions 1 and 4
10condensed with carbocyclic rings or ring systems
141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
16substituted in position 5 by aryl radicals
18substituted in position 2 by nitrogen, oxygen or sulfur atoms
22Sulfur atoms
A61K 31/41
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
C07D 243/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
243Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
06having the nitrogen atoms in positions 1,4
10condensed with carbocyclic rings or ring systems
141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
16substituted in position 5 by aryl radicals
18substituted in position 2 by nitrogen, oxygen or sulfur atoms
22Sulfur atoms
Applicants F. HOFFMANN-LA ROCHE AG
Inventors QINGJIE DING
JIN-JUN LIU
PETER MICHAEL WOVKULICH
GIACOMO PIZZOLATO
CHUNG-CHEN WEI
VINCENT STEWART MADISON
Agents ESTUDIO BARREDA MOLLER
Priority Data 60/130,370 21.04.1999 US
Title
(ES) PIRAZOLBENZODIAZEPINAS COMO INHIBIDORES DE QUINASAS DEPENDIENTES DE CICLINA
Abstract
(ES)
SE REFIERE A PIRAZOLBENZODIAZEPINAS DE FORMULA I, DONDE: R1 ES H, NO2, CN, HALOGENO, OR5, R6OR7, COOR7, CONR8R9, NR10R11, NHCOR12, NHSO2R13, ALQUILO OPCIONALMENTE SUSTITUIDO CON OH, HALOGENO; R2 Y R4 SON H, HALOGENO, NO2, CF3, ALQUILO; R3 ES H, CICLOALQUILO, ARILO, HETEROCICLO, HETEROARILO, ALQUENILO, CONR8R9, ALQUINILO O ALQUILO OPCIONALMENTE SUSTITUIDO POR OH, OR9, F, ARILO; R5 ES ALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO; R6 ES ALQUILO; R7 ES H, ALQUILO; R8 Y R9 SON H, ALQUILO OPCIONALMENTE SUSTITUIDO CON OH, NH2; R8 Y R9 FORMAN UN HETEROCICLO DE 5-6 MIEMBROS OPCIONALMENTE SUSTITUIDO CON OH, NH2, ALQUILO; R10, R11 Y R12 SON H, ALQUILO; R13 ES ALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, NR14R15; R14 Y R15 SON H, ALQUILO OPCIONALMENTE SUSTITUIDO CON HALOGENO O JUNTOS CON FORMAN UN HETEROCICLO. SON COMPUESTOS PREFERIDOS 3-METIL-5-(2-CLOROFENIL)-7-NITROPIRAZOL[3,4][1,4]BENZODIAZEPINA, 3-METIL-5-(2-FLUOROFENIL)PIRAZOL[3,4][1,4]BENZODIAZEPINA-7-CARBONITRILO, 3-METIL-5-(2-FLUOROFENIL)PIRAZOL[3,4][1,4]BENZODIAZEPINA-7-CARBOXAMIDA, 3-HIDROXIMETIL-5-(2-FLUOROFENIL)PIRAZOL[3,4][1,4]BENZODIAZEPINA-7-CARBONITRILO, ENTRE OTROS. LAS PIRAZOLBENZODIAZEPINAS INHIBEN LAS QUINASAS DEPENDIENTES DE CICLINA (CDKs) Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TUMORES DE MAMA, COLON, PULMON, PROSTATA
Also published as
CN1603314
ID031.523
DE000060014893
PT1185529
YUP-731/01
SG84049
EP1185529
RU02249593
CN1348455
CA2367704
AU2000047480
DK1185529
JP2002543081
CZ2001-3738
WO/2000/064900
JOP/2000/54
CO5170444
AR023542
MYPI 20001661
TH52651
NZ514523
IL145764
HRP20010742A
ININ/PCT/2001/1426/CHE
KR1020010112435
NO20015065
MXPA/a/2001/010545
MA26782
TR2001/03016
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