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1. (NZ602754) Substituted 1,3-benzothiazepines useful in treating metabolic disorders

Office : New Zealand
Application Number: 602754 Application Date: 27.04.2011
Publication Number: 602754 Publication Date: 30.05.2014
Grant Number: Grant Date: 02.09.2014
Publication Kind : B
Prior PCT appl.: Application Number:PCTUS2011034024 ; Publication Number: Click to see the data
IPC:
A61K 31/554
A61P 3/00
A61P 5/00
C07D 281/10
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
554
having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
281
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02
Seven-membered rings
04
having the hetero atoms in positions 1 and 4
08
condensed with carbocyclic rings or ring systems
10
condensed with one six-membered ring
CPC:
C07D 281/10
C07D 417/06
C07F 9/6541
A61K 31/554
A61K 31/675
C07D 285/36
C07F 9/6536
Applicants: GLAXOSMITHKLINE LLC
Inventors: AQUINO, Christopher Joseph
COLLINS, Jon Loren
COWAN, David John
WU, Yulin
Agents: HENRY HUGHES IP LIMITED
Priority Data: 61/328,212 27.04.2010 US
61/329,225 29.04.2010 US
Title: (EN) Substituted 1,3-benzothiazepines useful in treating metabolic disorders
Abstract:
(EN) 602754 Provided are dioxido-phenyl-benzothiazepin derivatives of formula (I), where Q, R1, R2, R3, R4 and X are as defined in the specification. An example of the derivatives is 3-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]carbonyl}amino)-2,2-dimethylpropanoic acid. Methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and therapeutic uses of them are further provided. These compounds are suitable for treating metabolic disorders, particularly diabetes mellitus (Type I and Type II) or obesity.
Also published as:
RSP-2016/0709UAa201211711IL222365EP2563122US20130029938JP2013525444
CN102858159SG184812CA2795543EA201290909DOP2012000263KR1020130060201
BR112012026767DK2563122ES2588743AU2011245393VN32773MYPI 2012004753
PH1/2012/502128TH145108IN2983/KOLNP/2012WO/2011/137135