Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (EP3122347) CELASTROL AND DERIVATIVES FOR THE TREATMENT OF OBESITY

Office : European Patent Office
Application Number: 15715606 Application Date: 26.03.2015
Publication Number: 3122347 Publication Date: 01.02.2017
Publication Kind : A1
Designated States: AL, AT, BA, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:US2015022746 ; Publication Number: Click to see the data
IPC:
A61K 31/19
A61K 31/194
A61K 31/198
A61K 38/22
A61K 45/06
A61P 3/04
A61P 43/00
C07C 1/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
194
having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
1
Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
CPC:
C07C 62/38
A61K 31/19
A61K 31/194
A61K 31/198
A61K 38/2264
A61K 45/06
Applicants: THE CHILDREN'S MEDICAL CENTER CORP
Inventors: MAZITSCHEK RALPH
ÖZCAN UMUT
Priority Data: 201461970839 26.03.2014 US
2015022746 26.03.2015 US
Title: (DE) CELASTROL UND DERIVATE ZUR BEHANDLUNG VON ADIPOSITAS
(EN) CELASTROL AND DERIVATIVES FOR THE TREATMENT OF OBESITY
(FR) CÉLASTROL ET SES DÉRIVÉS POUR LE TRAITEMENT DE L'OBÉSITÉ
Abstract:
(EN) Pentacyclic triterpene compounds are provided herein. Also provided are pharmaceutical formulations containing a therapeutically effective amount of one or more of the compounds, or pharmaceutically acceptable salts or prodrugs thereof, in combination with one or more pharmaceutically acceptable excipients. The pharmaceutical formulations can be administered to a pre-obese, obese, or morbidly obese patient to induce weight loss, reduce body fat, reduce food intake, improve glucose homeostasis, prevent obesity, or a combination thereof. The compounds can also be co-administered with leptin or a leptin analog.
(FR) La présente invention concerne des composés triterpéniques pentacycliques. L'invention concerne également des formulations pharmaceutiques contenant une quantité thérapeutiquement efficace d'un ou plusieurs desdits composés, ou de leurs sels ou de leurs promédicaments pharmaceutiquement acceptables, en combinaison avec un ou plusieurs excipients pharmaceutiquement acceptables. Les formulations pharmaceutiques peuvent être administrées à un patient pré-obèse, obèse ou obèse morbide pour induire une perte de poids, réduire les réserves lipidiques de l'organisme, réduire la ration alimentaire, améliorer l'homéostasie du glucose, prévenir l'obésité ou une combinaison de ceux-ci. Les composés peuvent également être administrés conjointement avec de la leptine ou un analogue de la leptine.
Also published as:
CA2944030AU2015235979JP2017513824CN107073016IN201617034080RU2016141567
WO/2015/148802