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1. (EP2945943) PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS

Office : European Patent Office
Application Number: 14702408 Application Date: 17.01.2014
Publication Number: 2945943 Publication Date: 25.11.2015
Publication Kind : B1
Designated States: AL, AT, BA, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, ME, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Prior PCT appl.: Application Number:US2014011957 ; Publication Number: Click to see the data
IPC:
C07D 403/12
C07D 237/32
C07D 401/10
C07D 401/12
C07D 403/10
C07D 405/12
C07D 413/10
C07D 413/12
C07D 417/10
C07D 417/12
C07D 417/14
C07D 471/04
C07D 487/04
C07D 491/048
C07D 513/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26
condensed with carbocyclic rings or ring systems
30
Phthalazines
32
with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
044
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
048
the oxygen-containing ring being five-membered
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
CPC:
C07D 217/24
C07D 237/32
C07D 401/10
C07D 401/12
C07D 403/10
C07D 403/12
C07D 405/12
C07D 413/10
C07D 413/12
C07D 417/10
C07D 417/12
C07D 417/14
C07D 471/04
C07D 487/04
C07D 491/048
C07D 513/04
A61K 31/422
A61K 31/428
A61K 31/437
A61K 31/4545
A61K 31/496
A61K 31/497
A61K 31/4985
A61K 31/502
A61K 31/519
A61K 31/5377
A61P 9/00
A61P 11/06
A61P 15/10
A61P 25/28
A61P 29/00
A61P 43/00
C07D 401/14
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 405/10
Applicants: SQUIBB BRISTOL MYERS CO
Inventors: GLUNZ PETER W
ZOU YAN
QUAN MIMI L
LADZIATA VLADIMIR
Priority Data: 201361754007 18.01.2013 US
2014011957 17.01.2014 US
Title: (DE) PHTHALAZINONE UND ISOCHINOLINONE ALS ROCK-INHIBITOREN
(EN) PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS
(FR) PHTALAZINONES ET ISOQUINOLINONES EN TANT QU'INHIBITEURS DE ROCK
Abstract:
(EN) The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
(FR) La présente invention concerne des composés de formule (I) ou leurs stéréo-isomères, tautomères, ou sels pharmaceutiquement acceptables, toutes les variables étant telles que définies ici. Ces composés sont des inhibiteurs ROCK sélectifs. L'invention porte en outre sur des compositions pharmaceutiques comprenant ces composés et sur des méthodes de traitement de maladies cardiovasculaires, du muscle lisse, oncologiques, neuropathologiques, auto-immunes, fibrotiques et/ou inflammatoires les utilisant.
Also published as:
CA2898440US20150353505CN105073741EA201591296JP2016505042BR112015017008
EP3252049EP3252050EA201790202IN7220/DELNP/2015ES2684776WO/2014/113620